The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis
Open accessAbstract
Retinoic acid-related orphan receptor α (RORα) is considered a key regulator of polarization in liver macrophages that is closely related to nonalcoholic steatohepatitis (NASH) pathogenesis. However, hepatic microenvironments that support the function of RORα as a polarity regulator were largely unknown. Here, we identified maresin 1 (MaR1), a docosahexaenoic acid (DHA) metabolite with a function of specialized proresolving mediator, as an endogenous ligand of RORα. MaR1 enhanced the expression and transcriptional activity of RORα and thereby increased the M2 polarity of liver macrophages. Administration of MaR1 protected mice from high-fat diet-induced NASH in a RORα-dependent manner. Surprisingly, RORα increased the level of MaR1 through transcriptional induction of 12-lipoxygenase (12-LOX), a key enzyme in MaR1 biosynthesis. Furthermore, we demonstrated that modulation of 12-LOX activity enhanced the protective function of DHA against NASH. Together, these results suggest that the MaR1/RORα/12-LOX autoregulatory circuit could offer potential therapeutic strategies for curing NASH.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“At least some of these lipid metabolites are produced by macrophages (101) and also signal to macrophages to reduce inflammatory and fibrogenic gene expression (102).”
From Hepatic Stellate Cell-Immune Interactions in NASH (2022) · cites this paper as [102]
In the citing paper
“A maresin 1/ RAR-related orphan receptor alpha (RORα)/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of MASH (102).”
From Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH) (2023) · cites this paper as [102]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981
Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428
Neuschwander-Tetri, B. A., Loomba, R., Sanyal, A. J., Lavine, J. E., Van Natta, M. L., Abdelmalek, M. F., Chalasani, N., Dasarathy, S., Diehl, A. M., Hameed, B., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61933-4 · Cited by 2,237
Liver Macrophages in Tissue Homeostasis and Disease
Krenkel, O., & Tacke, F. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.11 · Cited by 1,424
A lipidomic analysis of nonalcoholic fatty liver disease
Puri, P., Baillie, R. A., Wiest, M. M., Mirshahi, F., Choudhury, J., Cheung, O., Sargeant, C., Contos, M. J., & Sanyal, A. J. (2007) · Hepatology · doi:10.1002/hep.21763 · Cited by 1,338
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Huang, S. C., Everts, B., Ivanova, Y., O’Sullivan, D., Nascimento, M., Smith, A. M., Beatty, W. L., Love-Gregory, L. D., Lam, W. Y., O’Neill, C. M., et al. (2014) · Nature Immunology · doi:10.1038/ni.2956 · Cited by 1,256
Ratziu, V., Harrison, S. A., Francque, S., Bedossa, P., Lehert, P., Serfaty, L., Romero-Gomez, M., Boursier, J., Abdelmalek, M., Caldwell, S., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.01.038 · Cited by 1,035
Maresins: Novel macrophage mediators with potent antiinflammatory and proresolving actions
Serhan, C. N., Yang, R., Martinod, K., Kasuga, K., Pillai, P. S., Porter, T. F., Oh, S. F., & Spite, M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081880 · Cited by 908
Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation
Buckley, C. D., Gilroy, D. W., & Serhan, C. N. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.009 · Cited by 839
Jetten, A. M. (2009) · Nuclear Receptor Signaling · doi:10.1621/nrs.07003 · Cited by 700
Cited by
Sorted by citations
Mechanisms and disease consequences of nonalcoholic fatty liver disease
Loomba, R., Friedman, S. L., & Shulman, G. I. (2021) · Cell · doi:10.1016/j.cell.2021.04.015 · Cited by 2,002
Dyall, S. C., Balas, L., Bazan, N. G., Brenna, J. T., Chiang, N., Souza, F. D. C., Dalli, J., Durand, T., Galano, J., Lein, P. J., et al. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101165 · Cited by 707
Peiseler, M., Schwabe, R., Hampe, J., Kubes, P., Heikenwälder, M., & Tacke, F. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.06.012 · Cited by 564
Specialized pro-resolving mediator network: an update on production and actions
Chiang, N., & Serhan, C. N. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200018 · Cited by 455
Hepatic fibrosis 2022: Unmet needs and a blueprint for the future
Friedman, S. L., & Pinzani, M. (2022) · Hepatology · doi:10.1002/hep.32285 · Cited by 430
Maresin 1 activates LGR6 receptor promoting phagocyte immunoresolvent functions
Chiang, N., Libreros, S., Norris, P. C., de la Rosa, X., & Serhan, C. N. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129448 · Cited by 259
Vujkovic, M., Ramdas, S., Lorenz, K. M., Guo, X., Darlay, R., Cordell, H. J., He, J., Gindin, Y., Chung, C., Myers, R. P., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01078-z · Cited by 205
Hepatic macrophages: Key players in the development and progression of liver fibrosis
Cheng, D., Chai, J., Wang, H., Fu, L., Peng, S., & Ni, X. (2021) · Liver International · doi:10.1111/liv.14940 · Cited by 188
Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)
Wang, S., & Friedman, S. L. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adi0759 · Cited by 158
Innate Immunity in Diabetic Wound Healing: Focus on the Mastermind Hidden in Chronic Inflammatory
Geng, K., Ma, X., Jiang, Z., Huang, W. G., Gao, C., Pu, Y., Luo, L., Xu, Y., & Xu, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.653940 · Cited by 125
Maresin 1 promotes nerve regeneration and alleviates neuropathic pain after nerve injury
Wei, J., Su, W., Zhao, Y., Wei, Z., Hua, Y., Xue, P., Zhu, X., Chen, Y., & Chen, G. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02405-1 · Cited by 113
Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation
Sugimoto, S., Mena, H. A., Sansbury, B. E., Kobayashi, S., Tsuji, T., Wang, C., Yin, X., Huang, T. L., Kusuyama, J., Kodani, S. D., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00590-0 · Cited by 119
The Role and Mechanism of Oxidative Stress and Nuclear Receptors in the Development of NAFLD
Hong, T., Chen, Y., Li, X., & Lü, Y. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6889533 · Cited by 110
Hepatic macrophage targeted siRNA lipid nanoparticles treat non-alcoholic steatohepatitis
Zhou, J.-E., Sun, L., Liu, L., Jia, Y., Han, Y., Shao, J., Wang, J., Wang, Y., Yu, L., & Yan, Z. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.01.038 · Cited by 104
Self-citationSpecialized Pro-Resolving Mediators as Resolution Pharmacology for the Control of Pain and Itch
Ji, R. (2022) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-051921-084047 · Cited by 109
Kwon, Y. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900824 · Cited by 93
ROR: Nuclear Receptor for Melatonin or Not?
Ma, H., Kang, J., Fan, W., He, H., & Huang, F. P. (2021) · Molecules · doi:10.3390/molecules26092693 · Cited by 81
Hepatic Stellate Cell-Immune Interactions in NASH
Carter, J. K., & Friedman, S. L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.867940 · Cited by 79
Rodríguez, M. J., Sabaj, M., Tolosa, G., Vielma, F. H., Zúñiga, M. J., González, D. R., & Zúñiga‐Hernández, J. (2021) · Cells · doi:10.3390/cells10123406 · Cited by 83
Tiberi, M., & Chiurchiù, V. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.673549 · Cited by 80
Maresin-1 and Inflammatory Disease
Saito‐Sasaki, N., Sawada, Y., & Nakamura, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031367 · Cited by 78
Damage-mediated macrophage polarization in sterile inflammation
Koncz, G., Jenei, V., Tóth, M., Váradi, E., Kardos, B., Bácsi, A., & Mázló, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1169560 · Cited by 74
Musso, G., Saba, F., Cassader, M., & Gambino, R. (2023) · Progress in Lipid Research · doi:10.1016/j.plipres.2023.101238 · Cited by 71
Triglyceride lowering by omega-3 fatty acids: a mechanism mediated by N-acyl taurines
Bornfeldt, K. E. (2021) · Journal of Clinical Investigation · doi:10.1172/jci147558 · Cited by 58
Reprogramming of Hepatic Metabolism and Microenvironment in Nonalcoholic Steatohepatitis
Rui, L., & Lin, J. D. (2022) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-062220-105200 · Cited by 59
Treating inflammation to combat non-alcoholic fatty liver disease
Wiering, L., & Tacke, F. (2022) · Journal of Endocrinology · doi:10.1530/joe-22-0194 · Cited by 59
Jerab, D., Blangero, F., da Costa, P. C. T., Alves, J. L. D. B., Kéfi, R., Jamoussi, H., Morio, B., & Eljaafari, A. (2025) · Nutrients · doi:10.3390/nu17071253 · Cited by 66
Liang, T., Chen, T., Qiu, J., Gao, W., Qiu, X., Zhu, Y., Wang, X., Chen, Y., Zhou, H., Deng, Z., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04170-0 · Cited by 54
Lu, J., Feng, X., Zhang, H., Wei, Y., Yang, Y., Tian, Y., & Bai, L. (2020) · Connective Tissue Research · doi:10.1080/03008207.2020.1780218 · Cited by 52
Videla, L. A., Valenzuela, R., del Campo, A., & Zúñiga‐Hernández, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115528 · Cited by 53
Potential Clinical Applications of Pro-Resolving Lipids Mediators from Docosahexaenoic Acid
Beyer, M. P., Videla, L. A., Farías, C., & Valenzuela, R. (2023) · Nutrients · doi:10.3390/nu15153317 · Cited by 54
Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis
Zhang, X., She, Z., Wang, J., Sun, D., Shen, L., Xiang, H., Cheng, X., Ji, Y., Huang, Y., Li, P., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abg8117 · Cited by 49
Resolvin D1 protects against sepsis‐induced cardiac injury in mice
Wang, M., Liu, M., Zhang, J., Liu, J., Ye, J., Xu, Y. Q., Wang, Z., Ye, D., Zhao, M., & Wan, J. (2020) · BioFactors · doi:10.1002/biof.1668 · Cited by 47
Maresin-1 resolution with RORα and LGR6
Im, D. (2020) · Progress in Lipid Research · doi:10.1016/j.plipres.2020.101034 · Cited by 47
Effect of ω-3 Polyunsaturated Fatty Acids-Derived Bioactive Lipids on Metabolic Disorders
Duan, J., Song, Y., Zhang, X., & Wang, C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.646491 · Cited by 47
Bioactive signalling lipids as drivers of chronic liver diseases
Kaffe, E., Tisi, A., Magkrioti, C., Aidinis, V., Mehal, W. Z., Flavell, R. A., & Maccarrone, M. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.08.029 · Cited by 45
Han, Y., KyeongJin, L., Saha, A., Han, J., Choi, H., Noh, M., Lee, Y., & Lee, M. (2021) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2021.094 · Cited by 43
Self-citationFraser, D. A., Wang, X., Lund, J., Nikolić, N., Iruarrizaga-Lejarreta, M., Skjaeret, T., Alonso, C., Kastelein, J. J. P., Rustan, A. C., Kim, Y. O., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2021.12.004 · Cited by 41
Liu, W., Yang, Y.-H., Wang, Y.-C., Chang, W., & Wang, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311012 · Cited by 40
Miyazawa, K., Fukunaga, H., Tatewaki, Y., Takano, Y., Yamamoto, S., Mutoh, T., & Taki, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165783 · Cited by 37
Bioactive Lipid Mediators in the Initiation and Resolution of Inflammation after Spinal Cord Injury
David, S., & López‐Vales, R. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.04.026 · Cited by 41
Role of Specialized Pro-Resolving Mediators in Neuropathic Pain
Leuti, A., Fava, M., Pellegrini, N., & Maccarrone, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.717993 · Cited by 38
The dual role of lipids in chronic kidney disease: Pathogenic culprits and therapeutic allies
Giardini, E., Moore, D., Sadlier, D. M., Godson, C., & Brennan, E. P. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.118615 · Cited by 41
Zhang, Q., Wang, Y., Zhu, J., Zou, M., Zhang, Y., Wu, H., & Jin, T. (2025) · 中国科学通报:英文版 · doi:10.1016/j.scib.2024.07.049 · Cited by 35
Zhou, K., Chen, X., Zhang, L., Yang, Z., Zhu, H. H., Guo, D., Su, R., Chen, H., Li, H., Song, P., et al. (2021) · American Journal of Transplantation · doi:10.1111/ajt.16748 · Cited by 35
Grevengoed, T. J., Trammell, S. A. J., Svenningsen, J. S., Makarov, M. V., Nielsen, T. S., Jacobsen, J. C., Treebak, J. T., Calder, P. C., Migaud, M. E., Cravatt, B. F., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143861 · Cited by 34
Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway
Tang, D., Fu, G., Li, W., Sun, P., Loughran, P., Deng, M., Scott, M. J., & Billiar, T. R. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00280-9 · Cited by 34
Ye, J., Peng, J., Liu, K., Zhang, T., & Huang, W. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00354.2021 · Cited by 35
Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development
Alba, M. M., Ebright, B., Hua, B., Slarve, I., Zhou, Y., Jia, Y., Louie, S. G., & Stiles, B. L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1098467 · Cited by 32
Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer
Tian, M., Huang, B., He, N., Sun, L., Du, G., Gong, X., Xu, Y., Zheng, Y., Zheng, H., & Qu, H. (2020) · Mediators of Inflammation · doi:10.1155/2020/4539035 · Cited by 31
Chen, T., Dalton, G. D., Oh, S., Maeso‐Díaz, R., Du, K., Meyers, R. A., Guy, C. D., Abdelmalek, M. F., Henao, R., Guarnieri, P., et al. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.12.008 · Cited by 31
Maresin 1 activates brown adipose tissue and promotes browning of white adipose tissue in mice
Laiglesia, L. M., Escoté, X., Sáinź, N., Félix‐Soriano, E., Santamaría, E., Collantes, M., Fernández‐Galilea, M., Colón-Mesa, I., Martínez‐Fernández, L., Quesada‐López, T., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101749 · Cited by 32
Liu, Y., Hao, Y., Boeckmans, J., Rodrigues, R. M., & He, Y. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108353 · Cited by 30
The diverse roles of macrophages in metabolic inflammation and its resolution
Ray, A. G., Odum, O., Wiseman, D., & Weinstock, A. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1147434 · Cited by 31
Mechanisms of liver fibrosis in metabolic syndrome
Mehal, W. (2023) · eGastroenterology · doi:10.1136/egastro-2023-100015 · Cited by 28
Ma, Y., Jiang, J., Zhao, C., Wei, B., & Gao, J. (2025) · Hepatology Communications · doi:10.1097/hc9.0000000000000802 · Cited by 31
Wang, S.-W., Lan, T., Sheng, H., Zheng, F., Lei, M.-K., Wang, L.-X., Chen, H.-F., Xu, C.-Y., & Zhang, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.687744 · Cited by 28
Role of Omega-3 Fatty Acids as Non-Photic Zeitgebers and Circadian Clock Synchronizers
Checa-Ros, A., & D’Marco, L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012162 · Cited by 28
Maresin 1 Regulates Hepatic FGF21 in Diet‐Induced Obese Mice and in Cultured Hepatocytes
Martínez‐Fernández, L., González‐Muniesa, P., Sáinź, N., Laiglesia, L. M., Escoté, X., Martínez, J. A., & Moreno-Aliaga, M. J. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900358 · Cited by 26
Maresin-1 induces cardiomyocyte hypertrophy through IGF-1 paracrine pathway
Wahyuni, T., Kobayashi, A., Tanaka, S., Miyake, Y., Yamamoto, A., Bahtiar, A., Mori, S., Kametani, Y., Tomimatsu, M., Matsumoto, K., et al. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00568.2020 · Cited by 27
Yin, P., Wang, S., Wei, Y., Wang, X., Zhang, J., Yin, X., Feng, J., & Zhu, M. (2020) · Journal of Alzheimer’s Disease · doi:10.3233/jad-190682 · Cited by 24
Effects of Maresin 1 (MaR1) on Colonic Inflammation and Gut Dysbiosis in Diet-Induced Obese Mice
León, I. C., Quesada‐Vázquez, S., Sáinź, N., Guruceaga, E., Escoté, X., & Moreno-Aliaga, M. J. (2020) · Microorganisms · doi:10.3390/microorganisms8081156 · Cited by 24
Yu, H. Y., Niu, Y., Jia, G., Liang, Y., Chen, B., Sun, R., Wang, M., Huang, S., Zeng, J., Lu, J., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03005-8 · Cited by 24
Mariqueo, T. A., & Zúñiga‐Hernández, J. (2020) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2020.102095 · Cited by 24
Resolution of chronic inflammation and cancer
Tezcan, G., Yakar, N., Hastürk, H., Dyke, T. E. V., & Kantarcı, A. (2024) · Periodontology 2000 · doi:10.1111/prd.12603 · Cited by 25
Maresin-1 and its receptors RORα/LGR6 as potential therapeutic target for respiratory diseases
Zhao, M., Li, C., Zhang, J., Yin, Z., Zheng, Z., Wan, J., & Wang, M. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106337 · Cited by 23
Therapeutic potential of macrophage colony-stimulating factor in chronic liver disease
Keshvari, S., Genz, B., Teakle, N., Caruso, M., Ferrari-Cestari, M., Patkar, O. L., Tse, B. W., Sokolowski, K. A., Ebersbach, H., Jascur, J., et al. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049387 · Cited by 21
Hwang, S., Park, S., Kim, J. H., Bang, S.-B., Kim, H., Ka, N., Ko, Y., Kim, S.-S., Lim, G. Y., Lee, S., et al. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121827 · Cited by 22
Self-citationOmega-3 pleiad: The multipoint anti-inflammatory strategy
Batista, E. D. S., Nakandakari, S. C. B. R., da Silva, A. S. R., Pauli, J. R., de Moura, L. P., Ropelle, E. R., Camargo, E. A., & Cintra, D. E. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2146044 · Cited by 22
Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation
Yao, D., Qiao, F., Song, C., & Lv, Y. (2021) · Materials Science and Engineering C · doi:10.1016/j.msec.2021.112359 · Cited by 21
Lipid metabolism in tumor immunology and immunotherapy
Duong, L. K., Corbali, H. I., Riad, T. S., Ganjoo, S., Nanez, S., Voss, T. A., Barsoumian, H. B., Welsh, J. W., & Cortez, M. A. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1187279 · Cited by 21
Protective Potential of Maresins in Cardiovascular Diseases
Liu, M., He, H., & Chen, L. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.923413 · Cited by 21
Proresolving lipid mediators and liver disease
Clària, J., Flores‐Costa, R., Duran‐Güell, M., & López‐Vicario, C. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2021.159023 · Cited by 19
Kim, N., & Shin, H. Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25179598 · Cited by 19
The Role of Retinoic-Acid-Related Orphan Receptor (RORs) in Cellular Homeostasis
Nematisouldaragh, D., Kirshenbaum, E., Uzonna, M., Kirshenbaum, L. A., & Rabinovich-Nikitin, I. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252111340 · Cited by 21
Xia, F., Wang, H., Ye, T., Fu, X.-L., Tan, X., Zeng, Y., Fan, J., & Xu, Y. (2021) · Lipids in Health and Disease · doi:10.1186/s12944-021-01518-5 · Cited by 18
Yasmeen, N., Selvaraj, H., Lakhawat, S. S., Datta, M., Sharma, P. K., Jain, A., Khanna, R., Srinivasan, J., & Kumar, V. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115437 · Cited by 17
Effects of high-fat diet on liver injury after small bowel resection
Onufer, E. J., Han, Y., Czepielewski, R. S., Courtney, C. M., Sutton, S., Randolph, G. J., & Warner, B. W. (2020) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2020.02.037 · Cited by 18
Self-citationYao, D., & Lv, Y. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213036 · Cited by 18
The use of circulating miRNAs for the diagnosis, prognosis, and personalized treatment of MASLD
Tobaruela-Resola, A. L., Milagro, F. I., Mogna-Peláez, P., Moreno-Aliaga, M. J., Abete, I., & Zulet, M. Á. (2025) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-025-01110-w · Cited by 17
Han, Y., Choi, H., Kim, H., & Lee, M. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120846 · Cited by 17
Self-citationLiu, M., He, H., Fan, F., Qiu, L.-J., Zheng, F., Guan, Y., Yang, G., & Chen, L. (2023) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2023.05.005 · Cited by 17
Ağagündüz, D., Yeşildemir, Ö., Koçyiğit, E., Koçak, T., Ünaldı, B. Ö., Ayakdaş, G., & Budán, F. (2024) · Nutrients · doi:10.3390/nu16223812 · Cited by 18
Pro-resolving lipid mediators in diseases: exploring the molecular basis and clinical implication
Li, C., Wang, Z., Yang, Y., Jiang, Q., Jiang, Y., Xiao, J., Shen, L., Wu, W., & Li, C. (2026) · Molecular Biomedicine · doi:10.1186/s43556-025-00400-5 · Cited by 22
Lipoxygenases in chronic liver diseases: current insights and future perspectives
Heinrich, L., Booijink, R. S., Khurana, A., Weiskirchen, R., & Bansal, R. (2021) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.12.001 · Cited by 16
IGF2-NR4A2 Signaling Regulates Macrophage Subtypes to Attenuate Liver Cirrhosis
Yao, L., Hu, X., Yuan, M., Zhang, Q., Liu, P., Yang, L., Dai, K., & Jiang, Y. (2023) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2022.00392 · Cited by 15
Fukuishi, N., Takahama, K., Kurosaki, H., Ono, S., & Asai, H. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041491 · Cited by 18
Wu, J. T., Li, X., Xia, F., Teng, F., & Xu, Y. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2021.759825 · Cited by 15
Xiao, L., Wang, M., Zhang, W., Song, Y., Zeng, J., Li, H., Yu, H. Y., Li, L., Gao, P., & Yao, P. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00693-0 · Cited by 16
Maresins as novel anti-inflammatory actors and putative therapeutic targets in sepsis
Sun, Y., Sun, S., Chen, P., Dai, Y., Yang, D. J., Lin, Y., & Yi, L. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107113 · Cited by 15
Dubé, L., Spahis, S., Lachaîne, K., Lemieux, A., Monhem, H., Poulin, S.-M., Randoll, C., Travaillaud, E., Ould-Chikh, N.-E.-H., Marcil, V., et al. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0156 · Cited by 15
Exploiting oxidized lipids and the lipid‐binding GPCRs against cardiometabolic diseases
Guimarães, R. C., Gonçalves, T. T., & Leiria, L. O. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15321 · Cited by 15
Bioactive lipids and metabolic syndrome—a symposium report
DeVito, L. M., Dennis, E. A., Kahn, B. B., Shulman, G. I., Witztum, J. L., Sadhu, S., Nickels, J. T., Spite, M. R., Smyth, S. S., & Spiegel, S. (2022) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14752 · Cited by 12
Aoki, H., Isobe, Y., Yoshida, M., Kang, J. X., Maekawa, M., & Arita, M. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2022.159275 · Cited by 14
Teixeira-Santos, L., Martins, S., Sousa, T., Albino‐Teixeira, A., & Pinho, D. (2023) · PLoS ONE · doi:10.1371/journal.pone.0287392 · Cited by 14
Narrative Review: Glucocorticoids in Alcoholic Hepatitis—Benefits, Side Effects, and Mechanisms
Lü, H. (2022) · Journal of Xenobiotics · doi:10.3390/jox12040019 · Cited by 13
Sáinź, N., Fernández‐Galilea, M., Costa, A. G. V., Prieto-Hontoria, P. L., Barraco, G. M., & Moreno-Aliaga, M. J. (2020) · Food & Function · doi:10.1039/d0fo01445a · Cited by 13
Mouse models of nonalcoholic steatohepatitis and their application to new drug development
Phung, H. H., & Lee, C. H. (2022) · Archives of Pharmacal Research · doi:10.1007/s12272-022-01410-5 · Cited by 13
Lu, Y., Lu, G., Gao, L., Zhu, Q., Xue, J., Zhang, J., Ma, X., Ma, N., Yang, Q., Dong, J., et al. (2021) · Mediators of Inflammation · doi:10.1155/2021/6680456 · Cited by 14
Hu, Z., Zhao, Y., Jiang, J., Li, W., Su, G., Li, L., & Ran, J. (2023) · Environmental Toxicology · doi:10.1002/tox.23813 · Cited by 13
Metadata
- Authors
- Han, Y.-H., Shin, K.-O., Kim, J.-Y., Khadka, D. B., Kim, H.-J., Lee, Y.-M., Cho, W.-J., Cha, J.-Y., Lee, B.-J., & Lee, M.-O.
- Affiliations
- Seoul National University (KR)
- Chungbuk National University (KR)
- Chonnam National University (KR)
- Gachon University (KR)
- Corresponding author
- Lee, Mi-Ock
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2019-03-11
- Volume
- 129
- Issue
- 4
- Pages
- 1684-1698
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC6436872
- OpenAlex
- W2921132259
- Cited by
- 154
- References
- 56
- Citations by year
- 2026: 17 · 2025: 16 · 2024: 11 · 2023: 24 · 2022: 37 · 2021: 30 · 2020: 14 · 2019: 5
- FWCI
- 16.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- The National Research Foundation of Korea (2017R1A2B3011870, 2018R1A5A2024425)
- Korea Mouse Phenotyping Project (NRF-2014M3A9D5A01073556)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Keywords
- maresin 1, RORα, 12-lipoxygenase, nonalcoholic steatohepatitis, specialized pro-resolving mediators, docosahexaenoic acid metabolites, M2 macrophages, high-fat diet-induced liver injury, inflammation resolution, therapeutic target
- MeSH terms
- Animals, Arachidonate 12-Lipoxygenase, Dietary Fats, Docosahexaenoic Acids, Humans, Inflammation, Macrophages, Male, Mice, Knockout, Mice, Nuclear Receptor Subfamily 1, Group F, Member 1, Non-alcoholic Fatty Liver Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review