The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Dr. Jekyll and Mr. Hyde: ApoE explains opposing effects of neuronal LRP1
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Knockout of LRP1 in neurons resulted in reduced amyloid pathology.
“However, this effect may be cell type specific as knockout of LRP1 in neurons resulted in reduced amyloid pathology [88, 89].”
From ApoE lipoproteins in the central nervous system under homeostasis and role in Alzheimer’s disease and related disorders (2026) · cites this paper as [89]
The “ApoE4-mediated seeding of Aβ” section reports that neuronal LRP1 knockout prevents the increase in amyloid pathology caused by ApoE4. The claim omits that genotype condition: the “Therapeutic strategies for Aβ and ApoE genotype” section cautions that lowering neuronal LRP1 may be ineffective or deleterious in ApoE3 homozygotes. (LLM, conf=0.88)
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Citations
Cites
Neuronal Clearance of Amyloid-β by Endocytic Receptor LRP1
Kanekiyo, T., Cirrito, J. R., Liu, C.-C., Shinohara, M., Li, J., Schuler, D. R., Shinohara, M., Holtzman, D. M., & Bu, G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3487-13.2013 · Cited by 280
Self-citationSoluble Aβ Seeds Are Potent Inducers of Cerebral β-Amyloid Deposition
Langer, F., Eisele, Y. S., Fritschi, S. K., Staufenbiel, M., Walker, L. C., & Jucker, M. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3088-11.2011 · Cited by 237
Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone
Purro, S. A., Farrow, M. A., Linehan, J., Nazari, T., Thomas, D. X., Chen, Z., Mengel, D., Saito, T., Saido, T., Rudge, P., et al. (2018) · Nature · doi:10.1038/s41586-018-0790-y · Cited by 191
APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1
Tachibana, M., Holm, M.-L., Liu, C.-C., Shinohara, M., Aikawa, T., Oue, H., Yamazaki, Y., Martens, Y. A., Murray, M. E., Sullivan, P. M., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124853 · Cited by 156
The endosomal-lysosomal pathway is dysregulated by APOE4 expression in vivo
Nuriel, T., Peng, K. Y., Ashok, A., Dillman, A. A., Figueroa, H. Y., Apuzzo, J., Ambat, J., Levy, E., Cookson, M. R., Mathews, P. M., et al. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00702 · Cited by 140
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Research works printed but not linked: 11
- 10.1056/NEJMoa1202753 · DOI · Paper page
- 10.1038/nrd3505 · DOI · Paper page
- 10.1016/j.neurobiolaging.2004.02.027 · DOI · Paper page
- 10.1126/science.1197623 · DOI · Paper page
- 10.1038/s41586-018-0718-6 · DOI · Paper page
- 10.1016/j.neuron.2017.11.014 · DOI · Paper page
- 10.1016/j.neuron.2017.11.013 · DOI · Paper page
- 10.1007/s00401-017-1685-y · DOI · Paper page
- 10.1073/pnas.1220484110 · DOI · Paper page
- 10.1074/jbc.M112.420224 · DOI
- 10.1038/nn.4188 · DOI
Cited by
Sorted by citations
Strickland, M. R., & Holtzman, D. M. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00970-0
Self-citation
Metadata
- Authors
- Strickland, M. R., & Holtzman, D. M.
- Venue
- Journal of Clinical Investigation
- Published
- 2019-02-11
- Volume
- 129
- Issue
- 3
- Pages
- 969-971
- ISSN
- 0021-9738
- 1558-8238
- Cited by
- 13
- References
- 5
- Language
- en
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