The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense.
Open accessAbstract
To further understand the role of cytokine responses in symptom formation and host defenses in influenza infection, we determined the levels of IL-1beta, IL-2, IL-6, IL-8, IFN-alpha, TGF-beta, and TNF-alpha in nasal lavage fluid, plasma, and serum obtained serially from 19 volunteers experimentally infected with influenza A/Texas/36/91 (H1N1) and correlated these levels with various measures of infection and illness severity. We found that IL-6 and IFN-alpha levels in nasal lavage fluids peaked early (day 2) and correlated directly with viral titers, temperature, mucus production, and symptom scores. IL-6 elevations were also found in the circulation at this time point. In contrast, TNF-alpha responses peaked later (day 3 in plasma, day 4 in nasal fluids), when viral shedding and symptoms were subsiding. Similarly, IL-8 peaked late in the illness course (days 4-6) and correlated only with lower respiratory symptoms, which also occurred late. None of IL-1beta, IL-2, or TGF-beta levels increased significantly. These data implicate IL-6 and IFN-alpha as key factors both in symptom formation and host defense in influenza.
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Interleukin (IL)-6 directs the differentiation of IL-4-producing CD4+ T cells
Rincón, M., Anguita, J., Nakamura, T., Fikrig, E., & Flavell, R. A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.3.461 · Cited by 810
Zhu, Z., Tang, W., Ray, A., Wu, Y., Einarsson, O., Landry, M. L., Gwaltney, J., & Elias, J. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118431 · Cited by 282
Stimulation of tumor necrosis factor secretion by purified influenza virus neuraminidase
Houde, M., & Arora, D. J. S. (1990) · Cellular Immunology · doi:10.1016/0008-8749(90)90190-3 · Cited by 54
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Fraser, C., Riley, S., Anderson, R. M., & Ferguson, N. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307506101 · Cited by 1,144
Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus.
Kobasa, D., Jones, S. M., Shinya, K., Kash, J. C., Copps, J., Ebihara, H., Hatta, Y., Hyun Kim, J., Halfmann, P., Hatta, M., et al. (2007) · Nature · doi:10.1038/nature05495 · Cited by 934
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Sridhar, S., Begom, S., Bermingham, A., Hoschler, K., Adamson, W., Carman, W., Bean, T., Barclay, W., Deeks, J. J., & Lalvani, A. (2013) · Nature Medicine · doi:10.1038/nm.3350 · Cited by 862
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Metadata
- Authors
- Hayden, F. G., Fritz, R., Lobo, M. C., Alvord, W., Strober, W., & Straus, S. E.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-02-01
- Volume
- 101
- Issue
- 3
- Pages
- 643-649
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1974668319
- Cited by
- 677
- References
- 3
- FWCI
- 14.59
- Type
- journal article
- Language
- en
- Open access
- green
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- Hayden, F. G., Fritz, R., Lobo, M. C., Alvord, W., Strober, W., & Straus, S. E. (1998). Local and systemic cytokine responses during experimental human influenza A virus infection. Relation to symptom formation and host defense. Journal of Clinical Investigation. https://doi.org/10.1172/jci1355
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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