The DOI matches its Crossref record; 161 of the 163 references it cites were found in a registry or an index.
Hypoxia-inducible factors and diabetes
Open accessAbstract
Hypoxia can be defined as a relative deficiency in the amount of oxygen reaching the tissues. Hypoxia-inducible factors (HIFs) are critical regulators of the mammalian response to hypoxia. In normal circumstances, HIF-1α protein turnover is rapid, and hyperglycemia further destabilizes the protein. In addition to their role in diabetes pathogenesis, HIFs are implicated in development of the microvascular and macrovascular complications of diabetes. Improving glucose control in people with diabetes increases HIF-1α protein and has wide-ranging benefits, some of which are at least partially mediated by HIF-1α. Nevertheless, most strategies to improve diabetes or its complications via regulation of HIF-1α have not currently proven to be clinically useful. The intersection of HIF biology with diabetes is a complex area in which many further questions remain, especially regarding the well-conducted studies clearly describing discrepant effects of different methods of increasing HIF-1α, even within the same tissues. This Review presents a brief overview of HIFs; discusses the range of evidence implicating HIFs in β cell dysfunction, diabetes pathogenesis, and diabetes complications; and examines the differing outcomes of HIF-targeting approaches in these conditions.
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“Importantly, dysregulated HIF signaling also contributes to the pathogenesis of metabolic diseases, including diabetes mellitus and its complications [231,232].”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [231]
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Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy
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Hypoxia and hypoxia-inducible factors in diabetes and its complications
Catrina, S.-B., & Zheng, X. (2021) · Diabetologia · doi:10.1007/s00125-021-05380-z · Cited by 400
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Hypoxia Promotes Breast Cancer Cell Growth by Activating a Glycogen Metabolic Program
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Inflammatory Trajectory of Type 2 Diabetes: Novel Opportunities for Early and Late Treatment
Pellegrini, V., Grotta, R. L., Carreras, F., Giuliani, A., Sabbatinelli, J., Olivieri, F., Berra, C., Ceriello, A., & Prattichizzo, F. (2024) · Cells · doi:10.3390/cells13191662 · Cited by 105
Metadata
- Authors
- Gunton, J. E.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Gunton, Jenny E.
- ORCID
- Gunton, Jenny E.
- Venue
- Journal of Clinical Investigation
- Published
- 2020-09-14
- Volume
- 130
- Issue
- 10
- Pages
- 5063-5073
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- PMC
- PMC7524477
- OpenAlex
- W3071274483
- Cited by
- 159
- References
- 163
- Citations by year
- 2026: 22 · 2025: 24 · 2024: 25 · 2023: 40 · 2022: 33 · 2021: 15
- FWCI
- 2.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NHMRC (AppID1149976)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- hypoxia-inducible factor, HIF-1α, diabetes pathogenesis, hypoxia, hyperglycemia, beta-cell dysfunction, diabetes complications, microvascular complications, macrovascular complications, glycemic control
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Animals, Diabetes Mellitus, Glucose, Humans, Models, Biological, Tissue Distribution, Diabetes Complications, Basic Helix-Loop-Helix Transcription Factors, Basic Helix-Loop-Helix Proteins, Hypoxia-Inducible Factor 1, alpha Subunit
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