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Targeted expression of a human pituitary tumor–derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis
Open accessAbstract
It is estimated that up to one in five individuals develop pituitary gland tumors. Despite the common occurrence of these tumors, the pathogenetic mechanisms underlying their development remain largely unknown. We report the identification of a novel pituitary tumor-derived, N-terminally truncated isoform of FGF receptor-4 (ptd-FGFR4). The corresponding mRNA results from alternative transcription initiation and encodes a polypeptide that lacks a signal peptide and the first two extracellular Ig-like domains. ptd-FGFR4 has a distinctive cytoplasmic residence, is constitutively phosphorylated, and is transforming in vitro and in vivo. Here we show that targeted expression of ptd-FGFR4, but not FGFR4, results in pituitary tumors that morphologically recapitulate the human disease.
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Citations
Cited by
Pathogenesis of pituitary tumors
Melmed, S. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.40 · Cited by 466
The pathogenesis of pituitary tumours
Asa, S. L., & Ezzat, S. (2002) · Nature Reviews Cancer · doi:10.1038/nrc926 · Cited by 435
Self-citationTurkington, R. C., Longley, D. B., Allen, W. L., Stevenson, L., McLaughlin, K., Dunne, P. D., Blayney, J. K., Salto-Tellez, M., Van Schaeybroeck, S., & Johnston, P. G. (2014) · Cell Death & Disease · doi:10.1038/cddis.2014.10 · Cited by 98
A call to ARMS: targeting the PAX3-FOXO1 gene in alveolar rhabdomyosarcoma
Olanich, M. E., & Barr, F. G. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.772136 · Cited by 39
Metadata
- Authors
- Ezzat, S., Zheng, L., Zhu, X.-F., Wu, G. E., & Asa, S. L.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-01-01
- Volume
- 109
- Issue
- 1
- Pages
- 69-78
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2101998219
- Cited by
- 179
- References
- 0
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- green
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- Ezzat, S., Zheng, L., Zhu, X.-F., Wu, G. E., & Asa, S. L. (2002). Targeted expression of a human pituitary tumor–derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis. Journal of Clinical Investigation. https://doi.org/10.1172/jci14036
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