The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Metabolic changes in aging humans: current evidence and therapeutic strategies
Open accessAbstract
Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes. These age-related changes are further exacerbated by a sedentary lifestyle and can be in part prevented by maintenance of activity with aging. Here we explore the age-related changes seen in individual metabolic tissues - adipose, muscle, and liver - as well as globally in older adults. We also discuss the available evidence for therapeutic interventions such as caloric restriction, resistance training, and senolytic and senomorphic drugs to maintain healthy metabolism with aging, focusing on data from human studies.
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Cites
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What is the cause of the ageing atrophy?
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BackgroundSelf-citationDecline in skeletal muscle mitochondrial function with aging in humans
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Cited by
Best, L., Dost, T., Esser, D., Flor, S., Gamarra, A. M., Haase, M., Kadibalban, A. S., Marinos, G., Walker, A., Zimmermann, J., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-01959-z · Cited by 65
Wang, Z., Mei, H., Song, B., & Shi, Z. (2025) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2025.110638 · Cited by 6
Metadata
- Authors
- Palmer, A. K., & Jensen, M. D.
- Venue
- Journal of Clinical Investigation
- Published
- 2022-08-15
- Volume
- 132
- Issue
- 16
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W4291332516
- Cited by
- 331
- References
- 122
- FWCI
- 29.13
- Type
- journal article
- Language
- en
- Open access
- gold
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
