The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Endothelial lipase is a major determinant of HDL level
Open accessAbstract
A new member of the lipase gene family, initially termed endothelial lipase (gene nomenclature, LIPG; protein, EL), is expressed in a variety of different tissues, suggesting a general role in lipid metabolism. To assess the hypothesis that EL plays a physiological role in lipoprotein metabolism in vivo, we have used gene targeting of the native murine locus and transgenic introduction of the human LIPG locus in mice to modulate the level of EL expression. Evaluation of these alleles in a C57Bl/6 background revealed an inverse relationship between HDL cholesterol level and EL expression. Fasting plasma HDL cholesterol was increased by 57% in LIPG(-/-) mice and 25% in LIPG(+/-) mice and was decreased by 19% in LIPG transgenic mice as compared with syngeneic controls. Detailed analysis of lipoprotein particle composition indicated that this increase was due primarily to an increased number of HDL particles. Phospholipase assays indicated that EL is a primary contributor to phospholipase activity in mouse. These data indicate that expression levels of this novel lipase have a significant effect on lipoprotein metabolism.
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A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
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An Apolipoprotein Influencing Triglycerides in Humans and Mice Revealed by Comparative Sequencing
Pennacchio, L. A., Olivier, M., Hubacek, J. A., Cohen, J. C., Cox, D. R., Fruchart, J.-C., Krauss, R. M., & Rubin, E. M. (2001) · Science · doi:10.1126/science.1064852 · Cited by 921
Self-citationMezdour, H., Jones, R., Dengremont, C., Castro, G., & Maeda, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13570 · Cited by 113
Cited by
Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481
Peroxisome Proliferator-Activated Receptor Alpha Target Genes
Rakhshandehroo, M., Knoch, B., Müller, M., & Kersten, S. (2010) · PPAR Research · doi:10.1155/2010/612089 · Cited by 1,020
Shimamura, M., Matsuda, M., Yasumo, H., Okazaki, M., Fujimoto, K., Kono, K., Shimizugawa, T., Ando, Y., Koishi, R., Kohama, T., et al. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000252827.51626.89 · Cited by 297
Self-citationSchaap, F. G., Rensen, P. C. N., Voshol, P. J., Vrins, C., van der Vliet, H. N., Chamuleau, R. A. F. M., Havekes, L. M., Groen, A. K., & van Dijk, K. W. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403240200 · Cited by 300
Adam, R. C., Mintah, I. J., Alexa-Braun, C. A., Shihanian, L. M., Lee, J. S., Banerjee, P., Hamon, S. C., Kim, H. I., Cohen, J. C., Hobbs, H. H., et al. (2020) · Journal of Lipid Research · doi:10.1194/jlr.ra120000888 · Cited by 208
Metadata
- Authors
- Ishida, T., Choi, S., Kundu, R. K., Hirata, K.-I., Rubin, E. M., Cooper, A. D., & Quertermous, T.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-02-01
- Volume
- 111
- Issue
- 3
- Pages
- 347-355
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2036035171
- Cited by
- 306
- References
- 3
- FWCI
- 14.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ishida, T., Choi, S., Kundu, R. K., Hirata, K.-I., Rubin, E. M., Cooper, A. D., & Quertermous, T. (2003). Endothelial lipase is a major determinant of HDL level. Journal of Clinical Investigation. https://doi.org/10.1172/jci16306
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
