The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Involvement of PTEN in airway hyperresponsiveness and inflammation in bronchial asthma
Open accessAbstract
Phosphatase and tensin homologue deleted on chromosome ten (PTEN) is part of a complex signaling system that affects a variety of important cell functions. PTEN blocks the action of PI3K by dephosphorylating the signaling lipid phosphatidylinositol 3,4,5-triphosphate. We have used a mouse model for asthma to determine the effect of PI3K inhibitors and PTEN on allergen-induced bronchial inflammation and airway hyperresponsiveness. PI3K activity increased significantly after allergen challenge. PTEN protein expression and PTEN activity were decreased in OVA-induced asthma. Immunoreactive PTEN localized in epithelial layers around the bronchioles in control mice. However, this immunoreactive PTEN dramatically disappeared in allergen-induced asthmatic lungs. The increased IL-4, IL-5, and eosinophil cationic protein levels in bronchoalveolar lavage fluids after OVA inhalation were significantly reduced by the intratracheal administration of PI3K inhibitors or adenoviruses carrying PTEN cDNA (AdPTEN). Intratracheal administration of PI3K inhibitors or AdPTEN remarkably reduced bronchial inflammation and airway hyperresponsiveness. These findings indicate that PTEN may play a pivotal role in the pathogenesis of the asthma phenotype.
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Cites
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Pten is essential for embryonic development and tumour suppression
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Noninvasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography
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The lipid phosphatase activity of PTEN is critical for its tumor supressor function
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Cited by
Rivera, D. G., Hernández, I., Merino, N., Luque, Y., Álvarez, A., Martín, Y., Amador, A., Nuevas, L., & Delgado, R. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01328.x · Cited by 74
Metadata
- Authors
- Kwak, Y.-G., Song, C. H., Yi, H. K., Hwang, P. H., Kim, J.-S., Lee, K. S., & Lee, Y. C.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-04-01
- Volume
- 111
- Issue
- 7
- Pages
- 1083-1092
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2011575208
- Cited by
- 261
- References
- 22
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
