The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Collecting duct–specific gene inactivation of αENaC in the mouse kidney does not impair sodium and potassium balance
Open accessAbstract
Aldosterone controls the final sodium reabsorption and potassium secretion in the kidney by regulating the activity of the epithelial sodium channel (ENaC) in the aldosterone-sensitive distal nephron (ASDN). ASDN consists of the last portion of the distal convoluted tubule (late DCT), the connecting tubule (CNT), and the collecting duct (CD) (i.e., the cortical CD [CCD] and the medullary CD [MCD]). It has been proposed that the control of sodium transport in the CCD is essential for achieving sodium and potassium balance. We have tested this hypothesis by inactivating the alpha subunit of ENaC in the CD but leaving ENaC expression in the late DCT and CNT intact. Under salt restriction or under aldosterone infusion, whole-cell voltage clamp of principal cells of CCD showed no detectable ENaC activity, whereas large amiloride-sensitive currents were observed in control littermates. The animals survive well and are able to maintain sodium and potassium balance, even when challenged by salt restriction, water deprivation, or potassium loading. We conclude that the expression of ENaC in the CD is not a prerequisite for achieving sodium and potassium balance in mice. This stresses the importance of more proximal nephron segments (late DCT/CNT) to achieve sodium and potassium balance.
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Chang, S. S., Grunder, S., Hanukoglu, A., Rösler, A., Mathew, P. M., Hanukoglu, I., Schild, L., Lu, Y., Shimkets, R. A., Nelson-Williams, C., et al. (1996) · Nature Genetics · doi:10.1038/ng0396-248 · Cited by 808
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Cited by
Crowley, S. D., Gurley, S. B., Oliverio, M. I., Pazmino, A. K., Griffiths, R., Flannery, P. J., Spurney, R. F., Kim, H.-S., Smithies, O., Le, T. H., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23378 · Cited by 351
Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension
Barbaro, N. R., Foss, J. D., Kryshtal, D. O., Tsyba, N., Kumaresan, S., Xiao, L., Mernaugh, R. L., Itani, H. A., Loperena, R., Chen, W., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.002 · Cited by 282
Collecting duct–specific knockout of endothelin-1 causes hypertension and sodium retention
Ahn, D., Ge, Y., Stricklett, P. K., Gill, P., Taylor, D., Hughes, A. K., Yanagisawa, M., Miller, L., Nelson, R. D., & Kohan, D. E. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421064 · Cited by 263
Rossier, B. C., Staub, O., & Hummler, E. (2013) · FEBS Letters · doi:10.1016/j.febslet.2013.05.013 · Cited by 73
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Metadata
- Authors
- Rubera, I., Loffing, J., Palmer, L. G., Frindt, G., Fowler-Jaeger, N., Sauter, D., Carroll, T., McMahon, A., Hummler, E., & Rossier, B. C.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-08-15
- Volume
- 112
- Issue
- 4
- Pages
- 554-565
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2130632820
- Cited by
- 210
- References
- 1
- FWCI
- 4.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rubera, I., Loffing, J., Palmer, L. G., Frindt, G., Fowler-Jaeger, N., Sauter, D., Carroll, T., McMahon, A., Hummler, E., & Rossier, B. C. (2003). Collecting duct–specific gene inactivation of αENaC in the mouse kidney does not impair sodium and potassium balance. Journal of Clinical Investigation. https://doi.org/10.1172/jci16956
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