The DOI matches its Crossref record; 160 of the 160 references it cites were found in a registry or an index.
Clonal hematopoiesis and hematological malignancy
Abstract
Clonal hematopoiesis (CH), the expansion of hematopoietic stem cells and their progeny driven by somatic mutations in leukemia-associated genes, is a common phenomenon that rises in prevalence with advancing age to affect most people older than 70 years. CH remains subclinical in most carriers, but, in a minority, it progresses to a myeloid neoplasm, such as acute myeloid leukemia, myelodysplastic syndrome, or myeloproliferative neoplasm. Over the last decade, advances in our understanding of CH, its molecular landscape, and the risks associated with different driver gene mutations have culminated in recent developments that allow for a more precise estimation of myeloid neoplasia risk in CH carriers. In turn, this is leading to the development of translational and clinical programs to intercept and prevent CH from developing into myeloid neoplasia. Here, we give an overview of the spectrum of CH driver mutations, what is known about their pathophysiology, and how this informs the risk of incident myeloid malignancy.
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Metadata
- Authors
- Dunn, W. G., McLoughlin, M. A., & Vassiliou, G. S.
- Venue
- Journal of Clinical Investigation
- Published
- 2024-10-01
- Volume
- 134
- Issue
- 19
- ISSN
- 1558-8238
- Cited by
- 61
- References
- 160
- Language
- en
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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