The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Angiotensin II–accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice
Open accessAbstract
Osteopontin (OPN) is expressed in atherosclerotic lesions, particularly in diabetic patients. To determine the role of OPN in atherogenesis, ApoE-/-OPN+/+, ApoE-/-OPN+/-, and ApoE-/-OPN-/- mice were infused with Ang II, inducing vascular OPN expression and accelerating atherosclerosis. Compared with ApoE-/-OPN+/+ mice, ApoE-/-OPN+/- and ApoE-/-OPN-/- mice developed less Ang II-accelerated atherosclerosis. ApoE-/- mice transplanted with bone marrow derived from ApoE-/-OPN-/- mice had less Ang II-induced atherosclerosis compared with animals receiving ApoE-/-OPN+/+ cells. Aortae from Ang II-infused ApoE-/-OPN-/- mice expressed less CD68, C-C-chemokine receptor 2, and VCAM-1. In response to intraperitoneal thioglycollate, recruitment of leukocytes in OPN-/- mice was impaired, and OPN-/- leukocytes exhibited decreased basal and MCP-1-directed migration. Furthermore, macrophage viability in atherosclerotic lesions from Ang II-infused ApoE-/-OPN-/- mice was decreased. Finally, Ang II-induced abdominal aortic aneurysm formation in ApoE-/-OPN-/- mice was reduced and associated with decreased MMP-2 and MMP-9 activity. These data suggest an important role for leukocyte-derived OPN in mediating Ang II-accelerated atherosclerosis and aneurysm formation.
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Cites
Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E
Zhang, S. H., Reddick, R. L., Piedrahita, J. A., & Maeda, N. (1992) · Science · doi:10.1126/science.1411543 · Cited by 2,237
Boring, L., Gosling, J., Cleary, M., & Charo, I. F. (1998) · Nature · doi:10.1038/29788 · Cited by 1,965
Cited by
Osteopontin: role in immune regulation and stress responses
Wang, K. X., & Denhardt, D. T. (2008) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2008.08.001 · Cited by 669
Monocytes and macrophages in abdominal aortic aneurysm
Raffort, J., Lareyre, F., Clément, M., Hassen-Khodja, R., Chinetti, G., & Mallat, Z. (2017) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.52 · Cited by 432
Nomiyama, T., Perez-Tilve, D., Ogawa, D., Gizard, F., Zhao, Y., Heywood, E. B., Jones, K. L., Kawamori, R., Cassis, L. A., Tschöp, M. H., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31986 · Cited by 401
Self-citationWei, J., Marisetty, A., Schrand, B., Gabrusiewicz, K., Hashimoto, Y., Ott, M., Grami, Z., Kong, L.-Y., Ling, X., Caruso, H., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci121266 · Cited by 396
Beguier, F., Housset, M., Roubeix, C., Augustin, S., Zagar, Y., Nous, C., Mathis, T., Eandi, C., Benchaboune, M., Drame-Maigné, A., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.021 · Cited by 87
Metadata
- Authors
- Bruemmer, D., Collins, A. R., Noh, G., Wang, W., Territo, M., Arias-Magallona, S., Fishbein, M. C., Blaschke, F., Kintscher, U., Graf, K., Law, R. E., & Hsueh, W. A.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-11-01
- Volume
- 112
- Issue
- 9
- Pages
- 1318-1331
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2107843214
- Cited by
- 306
- References
- 2
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bruemmer, D., Collins, A. R., Noh, G., Wang, W., Territo, M., Arias-Magallona, S., Fishbein, M. C., Blaschke, F., Kintscher, U., Graf, K., Law, R. E., & Hsueh, W. A. (2003). Angiotensin II–accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci18141
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