C-reactive protein: a critical update

C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women

Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850

Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men

Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?

Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465

The Prognostic Value of C-Reactive Protein and Serum Amyloid A Protein in Severe Unstable Angina

Liuzzo, G., Biasucci, L. M., Gallimore, J. R., Grillo, R. L., Rebuzzi, A. G., Pepys, M. B., & Maseri, A. (1994) · New England Journal of Medicine · doi:10.1056/nejm199408183310701 · Cited by 2,354

C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men

Köenig, W., Sund, M., Fröhlich, M., Fischer, H.-G., Löwel, H., Döring, A., Hutchinson, W. L., & Pepys, M. B. (1999) · Circulation · doi:10.1161/01.cir.99.2.237 · Cited by 1,952

Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris

Thompson, S. G., Kienast, J., Pyke, S., Haverkate, F., & van de Loo, J. C. W. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321003 · Cited by 1,819

Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses

Danesh, J. (2000) · BMJ · doi:10.1136/bmj.321.7255.199 · Cited by 1,692

Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events

Ridker, P. M., Rifai, N., Clearfield, M., Downs, J. R., Weis, S. E., Miles, J. S., & Gotto, A. M. (2001) · New England Journal of Medicine · doi:10.1056/nejm200106283442601 · Cited by 1,557

Production of C-reactive protein and risk of coronary events in stable and unstable angina

Haverkate, E., Thompson, S. G., Pyke, S., Gallimore, J. R., & Mark B Pepys Group (1997) · The Lancet · doi:10.1016/s0140-6736(96)07591-5 · Cited by 1,511

Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein

Ridker, P. M., Rifai, N., Pfeffer, M. A., Sacks, F. M., & Braunwald, E. (1999) · Circulation · doi:10.1161/01.cir.100.3.230 · Cited by 1,471

Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study

Kuller, L. H., Tracy, R. P., Shaten, J., & Meilahn, E. N. (1996) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a008963 · Cited by 1,098

C-Reactive Protein–Mediated Low Density Lipoprotein Uptake by Macrophages

Zwaka, T. P., Hombach, V., & Torzewski, J. (2001) · Circulation · doi:10.1161/01.cir.103.9.1194 · Cited by 848

C-reactive protein induces human peripheral blood monocytes to synthesize tissue factor

Čermák, J., Key, N., Bach, R., Balla, J., Jacob, H., & Vercellotti, G. (1993) · Blood · doi:10.1182/blood.v82.2.513.513 · Cited by 838

The physiological structure of human C-reactive protein and its complex with phosphocholine

Thompson, D., Pepys, M. B., & Wood, S. P. (1999) · Structure · doi:10.1016/s0969-2126(99)80023-9 · Cited by 818

C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study

Freeman, D. J., Norrie, J. D., CASLAKE, M. J., Gaw, A., Ford, I., Lowe, G. D. O., O’Reilly, D. S. J., Packard, C. J., Sattar, N. A., & for the West of Scotland Coronary Prevention Study Group (2002) · Diabetes · doi:10.2337/diabetes.51.5.1596 · Cited by 727

C-Reactive Protein Binds to Apoptotic Cells, Protects the Cells from Assembly of the Terminal Complement Components, and Sustains an Antiinflammatory Innate Immune Response

Gershov, D., Kim, S., Brot, N., & Elkon, K. B. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1353 · Cited by 695

Association between C-reactive protein and features of the metabolic syndrome: a population-based study.

Fröhlich, M., Imhof, A., Berg‐Beckhoff, G., Hutchinson, W. L., Pepys, M. B., Boeing, H., Muche, R., Brenner, H., & Köenig, W. (2000) · Diabetes Care · doi:10.2337/diacare.23.12.1835 · Cited by 690

Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease.

Vigushin, D., Pepys, M., & Hawkins, P. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116336 · Cited by 681

Effect of Postmenopausal Hormones on Inflammation-Sensitive Proteins: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Study

Cushman, M., Legault, C., Barrett-Connor, E., Stefanick, M. L., Kessler, C., Judd, H. L., Sakkinen, P. A., & Tracy, R. P. (1999) · Circulation · doi:10.1161/01.cir.100.7.717 · Cited by 660

Body mass index, diabetes, and C-reactive protein among U.S. adults.

Ford, E. S. (1999) · Diabetes Care · doi:10.2337/diacare.22.12.1971 · Cited by 642

Elevation of C-reactive protein in “active” coronary artery disease

Berk, B. C., Weintraub, W. S., & Alexander, R. W. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90079-g · Cited by 593

Does Exercise Reduce Inflammation? Physical Activity and C-Reactive Protein Among U.S. Adults

Ford, E. S. (2002) · Epidemiology · doi:10.1097/00001648-200209000-00012 · Cited by 575

C-Reactive Protein Frequently Colocalizes With the Terminal Complement Complex in the Intima of Early Atherosclerotic Lesions of Human Coronary Arteries

Torzewski, J., Torzewski, M., Bowyer, D. E., Fröhlich, M., Köenig, W., Waltenberger, J. L., Fitzsimmons, C. M., & Hombach, V. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.9.1386 · Cited by 560

Effect of alcohol consumption on systemic markers of inflammation

Imhof, A., Froehlich, M., Brenner, H., Boeing, H., Pepys, M. B., & Koenig, W. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04170-2 · Cited by 559

Serum amyloid P component controls chromatin degradation and prevents antinuclear autoimmunity

Bickerstaff, M., Botto, M., Hutchinson, W., Herbert, J., Tennent, G., Bybee, A., Mitchell, D., Cook, H., Butler, P., Walport, M., et al. (1999) · Nature Medicine · doi:10.1038/9544 · Cited by 548

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis

Pepys, M. B., Herbert, J., Hutchinson, W. L., Tennent, G. A., Lachmann, H. J., Gallimore, J. R., Lovat, L. B., Bartfai, T., Alanine, A., Hertel, C., et al. (2002) · Nature · doi:10.1038/417254a · Cited by 540

C-reactive protein binds to both oxidized LDL and apoptotic cells through recognition of a common ligand: Phosphorylcholine of oxidized phospholipids

Chang, M.-K., Binder, C. J., Torzewski, M., & Witztum, J. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192399699 · Cited by 521

C-Reactive Protein and Complement Are Important Mediators of Tissue Damage in Acute Myocardial Infarction

Griselli, M., Herbert, J., Hutchinson, W. L., Taylor, K. M., Sohail, M., Krausz, T. N., & Pepys, M. B. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.12.1733 · Cited by 504

Hormone Replacement Therapy and Increased Plasma Concentration of C-Reactive Protein

Ridker, P. M., Hennekens, C. H., Rifai, N., Buring, J. E., & Manson, J. E. (1999) · Circulation · doi:10.1161/01.cir.100.7.713 · Cited by 442

C-Reactive Protein, Insulin Resistance, Central Obesity, and Coronary Heart Disease Risk in Indian Asians From the United Kingdom Compared With European Whites

Chambers, J. C., Eda, S., Bassett, P., Karim, M. Y., Thompson, S. G., Gallimore, J. R., Pepys, M. B., & Kooner, J. S. (2001) · Circulation · doi:10.1161/01.cir.104.2.145 · Cited by 439

C-Reactive Protein Colocalizes With Complement in Human Hearts During Acute Myocardial Infarction

Lagrand, W. K., Niessen, H. W. M., Wolbink, G., Jaspars, L. H., Visser, C. A., Verheugt, F. W. A., Meijer, C. J. L. M., & Hack, C. E. (1997) · Circulation · doi:10.1161/01.cir.95.1.97 · Cited by 388

Differentiation Between Obesity and Insulin Resistance in the Association With C-Reactive Protein

McLaughlin, T., Abbasi, F., Lamendola, C. A., Liang, L., Reaven, G. M., Schaaf, P., & Reaven, P. D. (2002) · Circulation · doi:10.1161/01.cir.0000041046.32962.86 · Cited by 369

Measurement of serum C-reactive protein concentration in myocardial ischaemia and infarction.

de Beer, F. C., Hind, C. R. K., Fox, K. M., Allan, R. M., Maseri, A., & Pepys, M. B. (1982) · Heart · doi:10.1136/hrt.47.3.239 · Cited by 357

C-Reactive Protein as a Predictor of Infarct Expansion and Cardiac Rupture After a First Q-Wave Acute Myocardial Infarction

Anzai, T., Yoshikawa, T., Shiraki, H., Asakura, Y., Akaishi, M., Mitamura, H., & Ogawa, S. (1997) · Circulation · doi:10.1161/01.cir.96.3.778 · Cited by 335

Regulation of complement activation by C-reactive protein

Mold, C., Gewurz, H., & Du Clos, T. W. (1999) · Immunopharmacology · doi:10.1016/s0162-3109(99)00007-7 · Cited by 326

Complement and Atherogenesis

Bhakdi, S., Torzewski, M., Klouche, M., & Hemmes, M. (1999) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.19.10.2348 · Cited by 325

Solid phase radioimmunoassays for human C-reactive protein

Shine, B. S. F., de Beer, F. C., & Pepys, M. B. (1981) · Clinica Chimica Acta · doi:10.1016/0009-8981(81)90005-x · Cited by 315

COMPLEMENT ACTIVATION BY C‐REACTIVE PROTEIN COMPLEXES*

Volanakis, J. E. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb22140.x · Cited by 279

Serum C-reactive protein concentration in acute myocardial infarction and its relationship to mortality during 24 months of follow-up in patients under thrombolytic treatment

Pietlla, K. O., Harmoinen, A. P. T., Jokiniitty, J. M., & Pasternack, A. I. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a015068 · Cited by 263

Immunoradiometric Assay of Circulating C-Reactive Protein: Age-related Values in the Adult General Population

Hutchinson, W. L., Köenig, W., Fröhlich, M., Sund, M., Lowe, G. D. O., & Pepys, M. B. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.7.934 · Cited by 250

Risk factors for coronary heart disease and acute-phase proteins. A population-based study

Danesh, J. (1999) · European Heart Journal · doi:10.1053/euhj.1998.1309 · Cited by 239

Interaction of C-reactive protein with artificial phosphatidylcholine bilayers

Volanakis, J. E., & WIRTZ, K. W. A. (1979) · Nature · doi:10.1038/281155a0 · Cited by 238

Coronary C-reactive protein distribution: its relation to development of atherosclerosis

Zhang, Y. X., Cliff, W. J., Schoefl, G. I., & Higgins, G. (1999) · Atherosclerosis · doi:10.1016/s0021-9150(99)00105-7 · Cited by 196

Low density lipoprotein and very low density lipoprotein are selectively bound by aggregated C-reactive protein.

de Beer, F. C., Soutar, A. K., Baltz, M. L., Trayner, I., Feinstein, A., & Pepys, M. B. (1982) · The Journal of Experimental Medicine · doi:10.1084/jem.156.1.230 · Cited by 182

Phosphorylcholine: friend or foe of the immune system?

Harnett, W., & Harnett, M. M. (1999) · Immunology Today · doi:10.1016/s0167-5699(98)01419-4 · Cited by 169

STUDIES OF ACUTE PHASE PROTEIN

Kushner, I., & Kaplan, M. H. (1961) · The Journal of Experimental Medicine · doi:10.1084/jem.114.6.961 · Cited by 164

PHYLOGENETIC ASPECTS OF C‐REACTIVE PROTEIN AND RELATED PROTEINS *

Baltz, M., de Beer, F., Feinstein, A., Munn, E., Milstein, C., Fletcher, T. C., March, J., Taylor, J., Bruton, C., Clamp, J. R., et al. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb22125.x · Cited by 157

Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene

Szalai, A. J., McCrory, M. A., Cooper, G. S., Wu, J., & Kimberly, R. P. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363820 · Cited by 147

C-reactive protein reacts with the U1 small nuclear ribonucleoprotein.

Clos, T. W. D. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.8.2553 · Cited by 124

STUDIES OF ACUTE-PHASE PROTEIN. II. LOCALIZATION OF Cx-REACTIVE PROTEIN IN HEART IN INDUCED MYOCARDIAL INFARCTION IN RABBITS*

Kushner, I., Rakita, L., & Kaplan, M. H. (1963) · Journal of Clinical Investigation · doi:10.1172/jci104715 · Cited by 117

Comparative studies on the binding properties of human and rabbit C-reactive proteins.

Oliveira, E. B., Gotschlich, E. C., & Liu, T. Y. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.124.3.1396 · Cited by 98

C-reactive protein as a predictor of cardiac rupture after acute myocardial infarction

Ueda, S., Ikeda, U., Yamamoto, K., Takahashi, M., Nishinaga, M., Nago, N., & Shimada, K. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90164-7 · Cited by 79

Human C-reactive protein does not bind to fcγRIIa on phagocyti cells

Saeland, E., van Royen‐Kerkhof, A., Hendriksen, K. A. W., Vilé-Weekhout, H., Rijkers, G. T., Sanders, E. A. M., & van de Winkel, J. G. J. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12418 · Cited by 45

Oral contraceptive use is associated with a systemic acute phase response

Fröhlich, M., Döring, A., Imhof, A., Hutchinson, W. L., Pepys, M. B., & Köenig, W. (1999) · Fibrinolysis and Proteolysis · doi:10.1054/fipr.1999.0037 · Cited by 31

Untitled work

(2001) · doi:10.1002/1521-4141(200112)31:12

Role of C-Reactive Protein at Sites of Inflammation and Infection

Sproston, N. R., & Ashworth, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00754 · Cited by 3,243

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

Lee, D. W., Kochenderfer, J. N., Stetler-Stevenson, M., Cui, Y. K., Delbrook, C., Feldman, S. A., Fry, T. J., Orentas, R., Sabatino, M., Shah, N. N., et al. (2015) · The Lancet · doi:10.1016/s0140-6736(14)61403-3 · Cited by 2,898

Current concepts in the diagnosis and management of cytokine release syndrome.

Lee, D. W., Gardner, R., Porter, D. L., Louis, C. U., Ahmed, N., Jensen, M., Grupp, S. A., & Mackall, C. L. (2014) · Blood · doi:10.1182/blood-2014-05-552729 · Cited by 2,806

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

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Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

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