The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88
Open accessAbstract
Toll-like receptors (TLRs) such as TLR2 and TLR4 have been implicated in host response to mycobacterial infection. Here, mice deficient in the TLR adaptor molecule myeloid differentiation factor 88 (MyD88) were infected with Mycobacterium tuberculosis (MTB). While primary MyD88(-/-) macrophages and DCs are defective in TNF, IL-12, and NO production in response to mycobacterial stimulation, the upregulation of costimulatory molecules CD40 and CD86 is unaffected. Aerogenic infection of MyD88(-/-) mice with MTB is lethal within 4 weeks with 2 log(10) higher CFU in the lung; high pulmonary levels of cytokines and chemokines; and acute, necrotic pneumonia, despite a normal T cell response with IFN-gamma production to mycobacterial antigens upon ex vivo restimulation. Vaccination with Mycobacterium bovis bacillus Calmette-Guerin conferred a substantial protection in MyD88(-/-) mice from acute MTB infection. These data demonstrate that MyD88 signaling is dispensable to raise an acquired immune response to MTB. Nonetheless, this acquired immune response is not sufficient to compensate for the profound innate immune defect and the inability of MyD88(-/-) mice to control MTB infection.
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Cited by
Cell-Mediated Immune Responses in Tuberculosis
Cooper, A. M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132703 · Cited by 1,162
Monocyte-Mediated Defense Against Microbial Pathogens
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Mycobacterium tuberculosis and the Macrophage: Maintaining a Balance
Pieters, J. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.05.006 · Cited by 503
Understanding Latent Tuberculosis: A Moving Target
Lin, P. L., & Flynn, J. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903856 · Cited by 488
Metadata
- Authors
- Fremond, C. M., Yeremeev, V., Nicolle, D. M., Jacobs, M., Quesniaux, V. F., & Ryffel, B.
- Venue
- Journal of Clinical Investigation
- Published
- 2004-12-15
- Volume
- 114
- Issue
- 12
- Pages
- 1790-1799
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2097333857
- Cited by
- 318
- References
- 47
- FWCI
- 12.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fremond, C. M., Yeremeev, V., Nicolle, D. M., Jacobs, M., Quesniaux, V. F., & Ryffel, B. (2004). Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88. Journal of Clinical Investigation. https://doi.org/10.1172/jci200421027
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