The case of visceral fat: argument for the defense
Open accessAbstract
Increased plasma fatty acid concentrations may be responsible for many of the metabolic abnormalities associated with abdominal obesity. Excessive visceral fat is associated with insulin resistance and other metabolic risk factors for coronary heart disease. A study reported in this issue of the JCI evaluates the relative contribution of fatty acids released during lipolysis of visceral adipose tissue triglycerides to portal and systemic fatty acid flux in human subjects.
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Increased hepatic de novo lipogenesis precedes the development of adipose tissue insulin resistance, which subsequently leads to increased flux of fatty acids to the liver.
“these results suggest that increased hepatic de novo lipogenesis precede the development of adipose tissue insulin resistance, which subsequently leads to increased flux of fatty acids to the liver (16, 17).”
From The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome (2007) · cites this paper as [16]
Only approximately 20% of portal vein FFA delivered to the liver and 14% of systemic FFA delivered to skeletal muscle are derived from lipolysis of VAT in obese subjects.
“In fact, only Ϸ20% of portal vein FFA delivered to the liver and 14% of systemic FFA delivered to skeletal muscle are derived from lipolysis of VAT in obese subjects (20,21).”
From Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity (2009) · cites this paper as [20]
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References 21 · Cited by 206
- Authors
- Klein, S.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Klein, Samuel
- ORCID
- Klein, Samuel
- Venue
- Journal of Clinical Investigation
- Published
- 2004-06-01
- Volume
- 113
- Issue
- 11
- Pages
- 1530-1532
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC419497
- OpenAlex
- W2142458796
- Cited by
- 206
- References
- 21
- Citations by year
- 2025: 7 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 2 · 2019: 6 · 2018: 11 · 2017: 4 · 2016: 11 · 2015: 12 · 2014: 16 · 2013: 11 · 2012: 13
- FWCI
- 9.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- visceral fat, abdominal obesity, plasma fatty acids, lipolysis, visceral adipose tissue, triglycerides, fatty acid flux, insulin resistance, coronary heart disease risk
- MeSH terms
- Adipose Tissue, Animals, Coronary Disease, Fatty Acids, Humans, Insulin, Kinetics, Liver, Portal System, Lipid Metabolism
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