The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Hyaluronic acid capsule modulates M protein-mediated adherence and acts as a ligand for attachment of group A Streptococcus to CD44 on human keratinocytes.
Open accessAbstract
We used wild-type and isogenic mutant strains of group A Streptococcus (GAS) that expressed M protein, capsule, or both to study the function of M protein and the hyaluronic acid capsular polysaccharide in attachment of GAS to human keratinocytes. Types 6 and 24, but not type 18, M protein were found to mediate attachment of GAS to soft palate or skin keratinocytes, but this interaction was prevented by the hyaluronic acid capsule on highly encapsulated, or mucoid, strains. Monoclonal antibody to CD44, the principal hyaluronic acid-binding receptor on keratinocytes, inhibited attachment of both highly encapsulated and poorly encapsulated wild type strains of GAS, but not the attachment of acapsular mutants. Transfection of K562 cells with cDNA encoding human CD44 conferred the capacity to bind each of six wild-type strains of GAS, but not to bind acapsular mutants. Because, in contrast to other potential adhesins, the group A streptococcal capsule is both highly conserved and surface-exposed, it may serve as a universal adhesin for attachment of diverse strains of GAS to keratinocytes of the pharyngeal mucosa and the skin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Hyaluronic acid capsule is a virulence factor for mucoid group A streptococci.
Wessels, M. R., Moses, A. E., Goldberg, J. B., & DiCesare, T. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8317 · Cited by 351
Self-citation
Cited by
Jong, A., Wu, C.-H., Chen, H.-M., Luo, F., Kwon-Chung, K. J., Chang, Y. C., LaMunyon, C. W., Plaas, A., & Huang, S.-H. (2007) · Eukaryotic Cell · doi:10.1128/ec.00120-07 · Cited by 113
Clathrin-independent endocytosis: A cargo-centric view
Maldonado-Báez, L., Williamson, C., & Donaldson, J. G. (2013) · Experimental Cell Research · doi:10.1016/j.yexcr.2013.08.008 · Cited by 97
Fisher, M., Huang, Y.-S., Li, X., McIver, K. S., Toukoki, C., & Eichenbaum, Z. (2008) · Infection and Immunity · doi:10.1128/iai.00300-08 · Cited by 90
Metadata
- Authors
- Schrager, H. M., Albertí, S., Cywes, C., Dougherty, G. J., & Wessels, M. R.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-04-15
- Volume
- 101
- Issue
- 8
- Pages
- 1708-1716
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2059086719
- Cited by
- 180
- References
- 1
- FWCI
- 11.47
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Hyaluronic acid capsule modulates M protein-mediated adherence and acts as a ligand for attachment of group A Streptococcus to CD44 on human keratinocytes. https://app.cochat.ai/papers/10.1172/jci2121
- The paper
- Schrager, H. M., Albertí, S., Cywes, C., Dougherty, G. J., & Wessels, M. R. (1998). Hyaluronic acid capsule modulates M protein-mediated adherence and acts as a ligand for attachment of group A Streptococcus to CD44 on human keratinocytes. Journal of Clinical Investigation. https://doi.org/10.1172/jci2121
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
