The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants.
Open accessAbstract
Long-term success in xenotransplantation is currently hampered by acute vascular rejection. The inciting cause of acute vascular rejection is not yet known; however, a variety of observations suggest that the humoral immune response of the recipient against the donor may be involved in the pathogenesis of this process. Using a pig-to-baboon heterotopic cardiac transplant model, we examined the role of antibodies in the development of acute vascular rejection. After transplantation into baboons, hearts from transgenic pigs expressing human decay-accelerating factor and CD59 underwent acute vascular rejection leading to graft failure within 5 d; the histology was characterized by endothelial injury and fibrin thrombi. Hearts from the transgenic pigs transplanted into baboons whose circulating antibodies were depleted using antiimmunoglobulin columns (Therasorb, Unterschleisshein, Germany) did not undergo acute vascular rejection in five of six cases. Biopsies from the xenotransplants in Ig-depleted baboons revealed little or no IgM or IgG, and no histologic evidence of acute vascular rejection in the five cases. Complement activity in the baboons was within the normal range during the period of xenograft survival. In one case, acute vascular rejection of a xenotransplant occurred in a baboon in which the level of antidonor antibody rose after Ig depletion was discontinued. This study provides evidence that antibodies play a significant role in the pathogenesis of acute vascular rejection, and suggests that acute vascular rejection might be prevented or treated by therapies aimed at the humoral immune response to porcine antigens.
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Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes.
Sandrin, M. S., Vaughan, H. A., Dabkowski, P. L., & McKenzie, I. F. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11391 · Cited by 605
Transplantation of discordant xenografts: a review of progress
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Self-citationIMMUNOPATHOLOGY OF HYPERACUTE XENOGRAFT REJECTION IN A SWINE-TO-PRIMATE MODEL
PLATT, J. L., FISCHEL, R. J., MATAS, A. J., REIF, S. A., BOLMAN, R. M., & BACH, F. H. (1991) · Transplantation · doi:10.1097/00007890-199108000-00006 · Cited by 449
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Renal Heterotransplmtation in Man
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Self-citationComplement-mediated regulation of tissue factor activity in endothelium.
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Self-citationTHE EFFECT OF SOLUBLE COMPLEMENT RECEPTOR TYPE 1 ON HYPERACUTE REJECTION OF PORCINE XENOGRAFTS
Pruitt, S. K., Kirk, A. D., Bollinger, R. R., Marsh, H. C., Collins, B. H., Levin, J. L., Mault, J. R., Heinle, J. S., Ibrahim, S., Rudolph, A. R., et al. (1994) · Transplantation · doi:10.1097/00007890-199402150-00009 · Cited by 262
Self-citationTransplantation of discordant xenografts: a challenge revisited
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Cited by
Reduced Binding of Human Antibodies to Cells From GGTA1/CMAH KO Pigs
Burlak, C., Paris, L. L., Lutz, A. J., Sidner, R. A., Estrada, J., Li, P., Tector, M., & Tector, A. J. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12744 · Cited by 87
Factors in Xenograft Rejection
ROBSON, S. C., AM ESCH, J. S., & BACH, F. H. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08509.x · Cited by 71
Metadata
- Authors
- Lin, S. S., Weidner, B. C., Byrne, G. W., Diamond, L. E., Lawson, J. H., Hoopes, C. W., Daniels, L. J., Daggett, C. W., Parker, W., Harland, R. C., Davis, R. D., Bollinger, R. R., Logan, J. S., & Platt, J. L.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-04-15
- Volume
- 101
- Issue
- 8
- Pages
- 1745-1756
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2032121728
- Cited by
- 273
- References
- 31
- FWCI
- 38.84
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lin, S. S., Weidner, B. C., Byrne, G. W., Diamond, L. E., Lawson, J. H., Hoopes, C. W., Daniels, L. J., Daggett, C. W., Parker, W., Harland, R. C., Davis, R. D., Bollinger, R. R., Logan, J. S., & Platt, J. L. (1998). The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. Journal of Clinical Investigation. https://doi.org/10.1172/jci2134
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