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Kidney stone disease
Open accessAbstract
About 5% of American women and 12% of men will develop a kidney stone at some time in their life, and prevalence has been rising in both sexes. Approximately 80% of stones are composed of calcium oxalate (CaOx) and calcium phosphate (CaP); 10% of struvite (magnesium ammonium phosphate produced during infection with bacteria that possess the enzyme urease), 9% of uric acid (UA); and the remaining 1% are composed of cystine or ammonium acid urate or are diagnosed as drug-related stones. Stones ultimately arise because of an unwanted phase change of these substances from liquid to solid state. Here we focus on the mechanisms of pathogenesis involved in CaOx, CaP, UA, and cystine stone formation, including recent developments in our understanding of related changes in human kidney tissue and of underlying genetic causes, in addition to current therapeutics.
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Citations
Cited by
Metabolic Evaluation and Recurrence Prevention for Urinary Stone Patients: EAU Guidelines
Skolarikos, A., Straub, M., Knoll, T., Sarica, K., Seitz, C., Petřík, A., & Türk, C. (2015) · European Urology · doi:10.1016/j.eururo.2014.10.029 · Cited by 409
Sequence variants in the CLDN14 gene associate with kidney stones and bone mineral density
Thorleifsson, G., Holm, H., Edvardsson, V., Walters, G. B., Styrkarsdottir, U., Gudbjartsson, D. F., Sulem, P., Halldorsson, B. V., de Vegt, F., d'Ancona, F. C. H., et al. (2009) · Nature Genetics · doi:10.1038/ng.404 · Cited by 309
Risk of Kidney Stones: Influence of Dietary Factors, Dietary Patterns, and Vegetarian–Vegan Diets
Ferraro, P. M., Bargagli, M., Trinchieri, A., & Gambaro, G. (2020) · Nutrients · doi:10.3390/nu12030779 · Cited by 303
Biochemical and stone-risk profiles with topiramate treatment
Welch, B. J., Graybeal, D., Moe, O. W., Maalouf, N. M., & Sakhaee, K. (2006) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2006.07.003 · Cited by 126
Herbal remedies for urinary stones used in India and China: A review
Kasote, D. M., Jagtap, S. D., Thapa, D., Khyade, M. S., & Russell, W. R. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.03.038 · Cited by 125
Metadata
- Authors
- Coe, F. L.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-10-01
- Volume
- 115
- Issue
- 10
- Pages
- 2598-2608
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2156729608
- Cited by
- 786
- References
- 0
- FWCI
- 19.98
- Type
- journal article
- Language
- en
- Open access
- bronze
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