The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors
Open accessAbstract
The fungal pathogen Candida albicans has a multilayered cell wall composed of an outer layer of proteins glycosylated with N- or O-linked mannosyl residues and an inner skeletal layer of beta-glucans and chitin. We demonstrate that cytokine production by human mononuclear cells or murine macrophages was markedly reduced when stimulated by C. albicans mutants defective in mannosylation. Recognition of mannosyl residues was mediated by mannose receptor binding to N-linked mannosyl residues and by TLR4 binding to O-linked mannosyl residues. Residual cytokine production was mediated by recognition of beta-glucan by the dectin-1/TLR2 receptor complex. C. albicans mutants with a cell wall defective in mannosyl residues were less virulent in experimental disseminated candidiasis and elicited reduced cytokine production in vivo. We concluded that recognition of C. albicans by monocytes/macrophages is mediated by 3 recognition systems of differing importance, each of which senses specific layers of the C. albicans cell wall.
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Cites
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793
Bellocchio, S., Montagnoli, C., Bozza, S., Gaziano, R., Rossi, G., Mambula, S. S., Vecchi, A., Mantovani, A., Levitz, S. M., & Romani, L. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.3059 · Cited by 515
Qian, Q., Jutila, M. A., Van Rooijen, N., & Cutler, J. E. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.10.5000 · Cited by 246
Munro, C. A., Bates, S., Buurman, E. T., Hughes, H. B., MacCallum, D. M., Bertram, G., Atrih, A., Ferguson, M. A. J., Bain, J. M., Brand, A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411413200 · Cited by 200
Molecular organization of the cell wall of Candida albicans
Klis, F. M., De Groot, P., & Hellingwerf, K. (2001) · Medical Mycology · doi:10.1080/744118876 · Cited by 111
Cited by
Pappas, P. G., Lionakis, M. S., Arendrup, M. C., Ostrosky-Zeichner, L., & Kullberg, B. J. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.26 · Cited by 1,636
The cell wall: a carbohydrate armour for the fungal cell
Latgé, J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05872.x · Cited by 987
An integrated model of the recognition of Candida albicans by the innate immune system
Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946
Self-citationCandida albicans morphogenesis and host defence: discriminating invasion from colonization
Gow, N. A. R., van de Veerdonk, F. L., Brown, A. J. P., & Netea, M. G. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2711 · Cited by 888
Self-citationHuman dectin-1 deficiency and mucocutaneous fungal infections
Ferwerda, B., Ferwerda, G., Plantinga, T. S., Willment, J. A., van Spriel, A. B., Venselaar, H., Elbers, C. C., Johnson, M. D., Cambi, A., Huysamen, C., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901053 · Cited by 752
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Metadata
- Authors
- Netea, M. G.
- Venue
- Journal of Clinical Investigation
- Published
- 2006-06-01
- Volume
- 116
- Issue
- 6
- Pages
- 1642-1650
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2171861423
- Cited by
- 753
- References
- 5
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
