Gene expression profiling gets to the root of human hair follicle stem cells
Open accessAbstract
Hair follicle stem cells sustain growth and cycling of the hair follicle and are located in the permanent portion of the follicle known as the bulge. In this issue of the JCI, Ohyama et al. report the characterization of global gene expression patterns of human hair follicle stem cells after their isolation using sophisticated laser capture techniques to microdissect out bulge cells. They discovered a panel of cell surface markers useful for isolating living hair follicle stem cells, a finding with potential therapeutic implications since isolated stem cells in mice can generate new hair follicles when transplanted to other mice. The findings of Ohyama et al. validate the use of the mouse for studying hair follicle biology but also underscore critical differences between mouse and human stem cell markers. In particular, CD34, which delineates hair follicle stem cells in the mouse, is not expressed by human hair follicle stem cells, while CD200 is expressed by stem cells in both species. Ultimately, this information will assist efforts to develop cell-based and cell-targeted treatments for skin disease.
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Bulge stem cells are the origin of sebaceous glands, epidermal basal layer, and hair follicle formation.
“Bulge stem cells are the origin of sebaceous glands, epidermal basal layer, and hair follicle formation, and they play an important role in the maintenance of the basic structure of the skin.”
From Morphological characteristics and notes of the skin in preclinical toxicity assessment (2023) · cites this paper as [32]
The passage on follicle regeneration says bulge stem cells regenerate the lower hair follicle and produce a new hair; the Identification of stem cells section also says mouse bulge cells generate all follicular lineages. Our copy does not say they give rise to sebaceous glands or the epidermal basal layer. Its reference to the basal layer concerns the follicle’s outer root sheath, not the epidermis. Page numbers are not supplied in the indexed passages. (LLM, conf=0.87)
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Cotsarelis, G., Sun, T.-T., & Lavker, R. M. (1990) · Cell · doi:10.1016/0092-8674(90)90696-c · Cited by 2,276 · see citing works
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Research works printed but not linked: 3
- Stauffer, B.L., Konhilas, J.P., Luczak, E.D., and Leinwand, L.A. 2006. Soy diet worsens heart disease in mice. J. Clin. Invest. 116:209-216. doi:10.1172/ JCI24676. · DOI
- Maron, B.J. 2002. Hypertrophic cardiomyopathy: a systematic review. J. Am. Med. Assoc. 287:1308-1320.
- Ohyama, M., et al. 2006. Characterization and iso- lation of stem cell-enriched human hair follicle bulge cells. J. Clin. Invest. 116:249-260. doi:10.1172/ JCI26043. · DOI
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Morphological characteristics and notes of the skin in preclinical toxicity assessment
Moroki, T. (2023) · Journal of Toxicologic Pathology · doi:10.1293/tox.2022-0103 · Cited by 26 · see citing works
Greaves, P. (2012) · Histopathology of Preclinical Toxicity Studies · doi:10.1016/b978-0-444-53856-7.00002-6 · Cited by 5 · see citing works
- Authors
- Cotsarelis, G.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Cotsarelis, G.
- ORCID
- Cotsarelis, G.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-12-08
- Volume
- 116
- Issue
- 1
- Pages
- 19-22
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1323274
- OpenAlex
- W2151034792
- Cited by
- 105
- References
- 1
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 7 · 2013: 8 · 2012: 3
- FWCI
- 6.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › dental development and anomalies
- Keywords
- hair follicle stem cells, gene expression profiling, cell surface markers, stem cell isolation, CD34, CD200, hair follicle regeneration, stem cell transplantation, skin disease treatment
- MeSH terms
- Animals, Cell Cycle, Humans, Stem Cells, Hair Follicle, Gene Expression Profiling, Mice
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