Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration
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cally assessed for EBV infection for 3 years had little effect on the frequency of silent seroconversion but greatly reduced the frequency of IM (20).This is an important result because it suggests that a vaccine to prevent IM might actually work and also because it points the way to the most sensible vaccine strategy, namely to try to prevent IM but not the normal silent infection with EBV.One can easily envisage how a partially effective gp350 vaccine might prevent IM but not silent EBV infection -if a high viral dose proves to be required for the development of IM, the immune response induced by the vaccine might be able to neutralize most of this virus (preventing IM) but not completely protect against infection.There is therefore an increasing case for further efforts to develop an EBV vaccine that could be given to EBV-seronegative teenagers or adults to try to prevent the development of IM.
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Activated macrophages and microglia may secrete chemokines and cytokines, causing further cellular damage, Bruch's membrane degradation, and angiogenesis.
“Activated macrophages and microglia may secrete chemokines and cytokines, causing further cellular damage, Bruch’s membrane degradation, and angiogenesis.143”
From Age-related macular degeneration (2008) · cites this paper as [143]
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References 21 · Cited by 29
Research works printed but not linked: 3
- Rickinson, A.B., and Kieff, E. 2001. Epstein-Barr virus. In Fields virology. D. Knipe and P.M. Howley, editors. Lippincott Williams & Wilkins. Philadel- phia, Pennsylvania, USA. 2575-2627.
- Mancao, C., and Hammerschmidt, W. 2007. Epstein-Barr virus latent membrane protein 2A is a B-cell receptor mimic and essential for B-cell sur- vival. Blood. In press.
- Niens, M., et al. 2007. HLA-A*02 is associated with a reduced risk and HLA-A*01 with an increased risk of developing EBV-positive Hodgkin lympho- ma. Blood. In press.
- Authors
- Chen, J., Connor, K. M., & Smith, L. E. H.
- Affiliations
- Boston Children's Hospital (US)
- Corresponding author
- Smith, Lois E.H.
- Venue
- Journal of Clinical Investigation
- Published
- 2007-10-01
- Volume
- 117
- Issue
- 10
- Pages
- 2758-2762
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1994636
- OpenAlex
- W2021852875
- Cited by
- 29
- References
- 21
- Citations by year
- 2024: 3 · 2022: 1 · 2018: 1 · 2017: 1 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Research to Prevent Blindness
- V. Kann Rasmussen Foundation (EY017017)
- National Institutes of Health (P01 HD18655)
- National Eye Institute (R01EY008670, F32EY017789, R21EY014811, EY017017, EY14811, EY008670, T32EY007145, R01EY017017)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD018655, P01 HD-18655)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- CX3CR1, microglia, macular degeneration, Epstein-Barr virus infection, Epstein-Barr virus, infectious mononucleosis, vaccination strategies
- MeSH terms
- CX3C Chemokine Receptor 1, Animals, Humans, Macular Degeneration, Retina, Microglia, Receptors, Chemokine, Genetic Predisposition to Disease, Mice
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