The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Identification in rats of a programming window for reproductive tract masculinization, disruption of which leads to hypospadias and cryptorchidism
Open accessAbstract
Becoming a phenotypic male is ultimately determined by androgen-induced masculinization. Disorders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, but their cause remains unclear. Together with the adult-onset disorders low sperm count and testicular cancer, they can constitute a testicular dysgenesis syndrome (TDS). Although masculinization is well studied, no unifying concept explains normal male reproductive development and its abnormalities, including TDS. We exposed rat fetuses to either anti-androgens or androgens and showed that masculinization of all reproductive tract tissues was programmed by androgen action during a common fetal programming window. This preceded morphological differentiation, when androgen action was, surprisingly, unnecessary. Only within the programming window did blocking androgen action induce hypospadias and cryptorchidism and altered penile length in male rats, all of which correlated with anogenital distance (AGD). Androgen-driven masculinization of females was also confined to the same programming window. This work has identified in rats a common programming window in which androgen action is essential for normal reproductive tract masculinization and has highlighted that measuring AGD in neonatal humans could provide a noninvasive method to predict neonatal and adult reproductive disorders. Based on the timings in rats, we believe the programming window in humans is likely to be 8-14 weeks of gestation.
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“Originating from the embryonic yolk sac, microglia migrate and colonize the brain during early development, around embryonic day (E)9.5 in mice.”
From Sex chromosomes and sex hormones differently shape microglial properties during normal physiological conditions in the adult mouse hippocampus (2025) · cites this paper as [31]
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“This precedes a hormonal surge in the brain, with androgens and estrogens peaking at around E17.5–18 [29–34].”
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“Normal masculinization of the fetus is dependent upon androgen secretion by the testis, and androgens act initially during a critical masculinization programming window to ensure normal male reproductive development [3–5].”
From Alternative (backdoor) androgen production and masculinization in the human fetus (2019) · cites this paper as [5]
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Citations
Cites
The Physiology of Reproduction
Legendre, M., & Jalabert, B. (1988) · Annals of Internal Medicine · doi:10.7326/0003-4819-109-2-176_1 · Cited by 7,876
Skakkebæk, N. E., Meyts, E. R., & Main, K. M. (2001) · Human Reproduction · doi:10.1093/humrep/16.5.972 · Cited by 2,261
Male development of chromosomally female mice transgenic for Sry
Koopman, P. A., Gubbay, J., Vivian, N., Goodfellow, P. N., & Lovell-Badge, R. H. (1991) · Nature · doi:10.1038/351117a0 · Cited by 2,193
Decrease in anogenital distance among male infants with prenatal phthalate exposure
Swan, S. H., Main, K. M., Liu, F., Stewart, S. L., Kruse, R. L., Calafat, A. M., Mao, C. S., Redmon, J. B., Ternand, C. L., Sullivan, S., et al. (2005) · Environmental Health Perspectives · doi:10.1289/ehp.8100 · Cited by 1,586
Brodie, S. E. (1996) · Survey of Ophthalmology · doi:10.1016/s0039-6257(96)80075-0 · Cited by 770
Testosterone Formation and Metabolism During Male Sexual Differentiation in the Human Embryo
Siiteri, P. K., & Wilson, J. D. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-1-113 · Cited by 591
Studies on Sex Differentiation in Mammals
JOST, A., Vigier, B., Prépin, J., & PERCHELLET, J. P. (1973) · Elsevier eBooks · doi:10.1016/b978-0-12-571129-6.50004-x · Cited by 566
Fisher, J. S. (2003) · Human Reproduction · doi:10.1093/humrep/deg273 · Cited by 550
Difference in prevalence of congenital cryptorchidism in infants between two Nordic countries
Boisen, K. A., Kaleva, M. M., Main, K. M., Virtanen, H. E., Haavisto, A.-M., Schmidt, I., Chellakooty, M., Damgaard, I., Kai, C. M., Reunanen, M. S., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)15998-9 · Cited by 510
Testicular dysgenesis syndrome: mechanistic insights and potential new downstream effects
Sharpe, R. M., & Skakkebæk, N. E. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.12.026 · Cited by 452
Flagged first, then by citations
Research works printed but not linked: 10
- Jost, 1972, Johns Hopkins Med. J., 130, 38
- Sharpe, 2008, Fertil. Steril.
- Inomata, 1985, Jikken Dobutsu., 34, 439
- Jirasek, 1977, Birth Defects Orig. Artic. Ser., 13, 13
- Wyndham, 1943, J. Anat., 77, 179
- 10.1210/en.131.3.1149 · DOI
- Jost, 1973, Recent Prog. Horm. Res., 29, 1
- Stinnakre, 1975, Arch. Anat. Microsc. Morphol. Exp., 64, 45
- Murakami, 1987, J. Anat., 153, 223
- Hsieh, 2008, Curr. Urol. Rep.
Cited by
Sorted by citations
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“…abnormalities (Tsai et al. , 2006) Testis near Wild type; spermatogenesis normal (Tsai et al. , 2006) PMC-ARKO Normal until puberty; indirect LC effects (Zhang et al. , 2006; Welsh et al. , 2008, 2009) Disorganized epithelium; reduced GC; infertility (Zhang et al. , 2006; Welsh et al. , 2009) .”
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Mola, G., Draskau, M. K., Jørgensen, A., Chalmel, F., Melau, C., Evrard, B., Mandrup, K. R., Hegaard, H. K., Hueg, T. K., Frederiksen, H. W., et al. (2026) · Communications Medicine · doi:10.1038/s43856-026-01815-z
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“…utero during the masculinization programming window (gestational weeks 8–14) and is considered a lifelong marker of the prenatal hormonal environment (Welsh et al. , 2008; Schwartz et al. , 2019) as well as of prenatal exposure to endocrine disruptors (Bornehag et al. , 2015; Swan et al. , 2015).”
Ruiz-Antonio, D. L., Castro, K. E. N., Garay-Canales, C. A., Rodríguez-Santiago, Y., Ríos-Avila, M. D. S., Zavala-López, C. A., Pavón, L., Pérez‐Sánchez, G., Diaz, L., & Morales‐Montor, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1838242
Eleveld, T. F., Janssen, F. W., Mego, M., & Looijenga, L. H. J. (2026) · Endocrinology · doi:10.1007/978-3-319-29456-8_48-1
England, G., Byers, A. S., Blanchard, R. N., Lewis, T., Moxon, R., & Lea, R. G. (2026) · Theriogenology · doi:10.1016/j.theriogenology.2026.118246
Kim, D., Chong, C., Yang, G.-E., Kim, H., & Choi, J. (2026) · Environment International · doi:10.1016/j.envint.2026.110556
Silva, D. S. (2011) · Aleph UCLA Undergraduate Research Journal for the Humanities and Social Sciences
Metadata
- Authors
- Welsh, M., Saunders, P. T. K., Fisken, M., Scott, H. M., Hutchison, G. R., Smith, L. B., & Sharpe, R. M.
- Affiliations
- The Queen's Medical Research Institute (GB)
- Corresponding author
- Welsh, Michelle
- Venue
- Journal of Clinical Investigation
- Published
- 2008-04-01
- Volume
- 118
- Issue
- 4
- Pages
- 1479-1490
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2267017
- OpenAlex
- W2003163696
- Cited by
- 781
- References
- 61
- Citations by year
- 2026: 23 · 2025: 39 · 2024: 27 · 2023: 54 · 2022: 58 · 2021: 43 · 2020: 54 · 2019: 47 · 2018: 49 · 2017: 38 · 2016: 45 · 2015: 48 · 2014: 45 · 2013: 42 · 2012: 39
- FWCI
- 17.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Edinburgh Napier Research Repository (Edinburgh Napier University) (submittedVersion, cc-by-nc)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Urology › Urological Disorders and Treatments
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Keywords
- fetal programming, hypospadias, cryptorchidism, testicular dysgenesis, androgen action, androgen receptor antagonists, androgens, anogenital distance, penile length, fetal development, pregnancy timing
- MeSH terms
- Androgens, Animals, Cryptorchidism, Embryo, Mammalian, Female, Gonads, Hypospadias, Male, Receptors, Androgen, Sex Characteristics, Sex Differentiation, Testosterone, Rats, Wistar, Rats
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