The cytokine network in asthma and chronic obstructive pulmonary disease
Open accessAbstract
Asthma and chronic obstructive pulmonary disease (COPD) are very common inflammatory diseases of the airways. They both cause airway narrowing and are increasing in incidence throughout the world, imposing enormous burdens on health care. Cytokines play a key role in orchestrating the chronic inflammation and structural changes of the respiratory tract in both asthma and COPD and have become important targets for the development of new therapeutic strategies in these diseases.
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Allergic asthma is primarily mediated by Th2 cells and is associated with imbalance of Th1/Th2 cells.
“It is generally believed that allergic asthma is primarily mediated by Th2 cells, and associated with imbalance of Th1/Th2 cells [36].”
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References 130 · Cited by 982
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- Authors
- Barnes, P. J.
- Affiliations
- Imperial College London (GB)
- Corresponding author
- Barnes, Peter J.
- ORCID
- Barnes, Peter J.
- Venue
- Journal of Clinical Investigation
- Published
- 2008-11-03
- Volume
- 118
- Issue
- 11
- Pages
- 3546-3556
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2575722
- OpenAlex
- W2050237494
- Cited by
- 982
- References
- 130
- Citations by year
- 2026: 30 · 2025: 43 · 2024: 25 · 2023: 28 · 2022: 55 · 2021: 59 · 2020: 67 · 2019: 55 · 2018: 54 · 2017: 66 · 2016: 88 · 2015: 63 · 2014: 56 · 2013: 73 · 2012: 71
- FWCI
- 5.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- AstraZeneca
- GlaxoSmithKline
- Daiichi-Sankyo
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- cytokines, asthma, chronic obstructive pulmonary disease, airway inflammation, airway remodeling, chronic inflammation, therapeutic target
- MeSH terms
- Asthma, Humans, Models, Biological, Cytokines, Pulmonary Disease, Chronic Obstructive
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