The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice
Open accessAbstract
Adipose tissue inflammation is linked to the pathogenesis of insulin resistance. In addition to exerting death-promoting effects, the death receptor Fas (also known as CD95) can activate inflammatory pathways in several cell lines and tissues, although little is known about the metabolic consequence of Fas activation in adipose tissue. We therefore sought to investigate the contribution of Fas in adipocytes to obesity-associated metabolic dysregulation. Fas expression was markedly increased in the adipocytes of common genetic and diet-induced mouse models of obesity and insulin resistance, as well as in the adipose tissue of obese and type 2 diabetic patients. Mice with Fas deficiency either in all cells or specifically in adipocytes (the latter are referred to herein as AFasKO mice) were protected from deterioration of glucose homeostasis induced by high-fat diet (HFD). Adipocytes in AFasKO mice were more insulin sensitive than those in wild-type mice, and mRNA levels of proinflammatory factors were reduced in white adipose tissue. Moreover, AFasKO mice were protected against hepatic steatosis and were more insulin sensitive, both at the whole-body level and in the liver. Thus, Fas in adipocytes contributes to adipose tissue inflammation, hepatic steatosis, and insulin resistance induced by obesity and may constitute a potential therapeutic target for the treatment of insulin resistance and type 2 diabetes.
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Cited by
Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis
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Winer, D. A., Winer, S., Shen, L., Wadia, P. P., Yantha, J., Paltser, G., Tsui, H., Wu, P., Davidson, M. G., Alonso, M. N., et al. (2011) · Nature Medicine · doi:10.1038/nm.2353 · Cited by 1,050
Contribution of Adipose Tissue Inflammation to the Development of Type 2 Diabetes Mellitus
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Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications
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Šestan, M., Marinović, S., Kavazović, I., Cekinović, Đ., Wueest, S., Turk Wensveen, T., Brizić, I., Jonjić, S., Konrad, D., Wensveen, F. M., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.05.005 · Cited by 189
Self-citation
Metadata
- Authors
- Wueest, S., Rapold, R. A., Schumann, D. M., Rytka, J. M., Schildknecht, A., Nov, O., Chervonsky, A. V., Rudich, A., Schoenle, E. J., Donath, M. Y., & Konrad, D.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-01-04
- Volume
- 120
- Issue
- 1
- Pages
- 191-202
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1986656589
- Cited by
- 162
- References
- 11
- FWCI
- 8.64
- Type
- journal article
- Language
- en
- Open access
- green
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- Wueest, S., Rapold, R. A., Schumann, D. M., Rytka, J. M., Schildknecht, A., Nov, O., Chervonsky, A. V., Rudich, A., Schoenle, E. J., Donath, M. Y., & Konrad, D. (2010). Deletion of Fas in adipocytes relieves adipose tissue inflammation and hepatic manifestations of obesity in mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci38388
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