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The ovary: basic biology and clinical implications
Open accessAbstract
The classical view of ovarian follicle development is that it is regulated by the hypothalamic-pituitary-ovarian axis, in which gonadotropin-releasing hormone (GnRH) controls the release of the gonadotropic hormones follicle-stimulating hormone (FSH) and luteinizing hormone (LH), and that ovarian steroids exert both negative and positive regulatory effects on GnRH secretion. More recent studies in mice and humans indicate that many other intra-ovarian signaling cascades affect follicular development and gonadotropin action in a stage- and context-specific manner. As we discuss here, mutant mouse models and clinical evidence indicate that some of the most powerful intra-ovarian regulators of follicular development include the TGF-beta/SMAD, WNT/FZD/beta-catenin, and RAS/ERK1/2 signaling pathways and the FOXO/FOXL2 transcription factors.
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“In turn, FSH and LH act on the ovary to regulate oocyte maturation, ovulation, and steroid hormone production [5].”
From Stress and the HPA Axis: Balancing Homeostasis and Fertility. (2017) · cites this paper as [5]
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Cited by
Sorted by citations
Stress and the HPA Axis: Balancing Homeostasis and Fertility.
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Metadata
- Authors
- Richards, J. S., & Pangas, S. A.
- Affiliations
- Baylor College of Medicine (US)
- ORCID
- Pangas, Stephanie A.
- Venue
- Journal of Clinical Investigation
- Published
- 2010-04-01
- Volume
- 120
- Issue
- 4
- Pages
- 963-972
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC2846061
- OpenAlex
- W2078292875
- Cited by
- 561
- References
- 4
- Citations by year
- 2026: 55 · 2025: 46 · 2024: 50 · 2023: 51 · 2022: 43 · 2021: 25 · 2020: 19 · 2019: 32 · 2018: 36 · 2017: 29 · 2016: 28 · 2015: 25 · 2014: 26 · 2013: 39 · 2012: 25
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dan L. Duncan Cancer Center, Baylor College of Medicine
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD016229, HD-07945, R56HD016229, HD16229, R01HD016272, HD 16272, F32HD007945, R37HD016229)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- ovarian follicle development, hypothalamic-pituitary-ovarian axis, gonadotropin-releasing hormone, follicle-stimulating hormone, luteinizing hormone, TGF-β/Smad signaling, Wnt/β-catenin signaling, FOXO transcription factors, FOXL2, mutant mouse models, ovarian steroids
- MeSH terms
- Forkhead Box Protein O3, Forkhead Box Protein L2, Animals, Cell Differentiation, Female, Follicle Stimulating Hormone, Ovarian Follicle, Humans, Oocytes, Ovary, Ovulation, Transforming Growth Factor beta, Forkhead Transcription Factors
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