The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Adult mouse epicardium modulates myocardial injury by secreting paracrine factors
Open accessAbstract
The epicardium makes essential cellular and paracrine contributions to the growth of the fetal myocardium and the formation of the coronary vasculature. However, whether the epicardium has similar roles postnatally in the normal and injured heart remains enigmatic. Here, we have investigated this question using genetic fate-mapping approaches in mice. In uninjured postnatal heart, epicardial cells were quiescent. Myocardial infarction increased epicardial cell proliferation and stimulated formation of epicardium-derived cells (EPDCs), which remained in a thickened layer on the surface of the heart. EPDCs did not adopt cardiomyocyte or coronary EC fates, but rather differentiated into mesenchymal cells expressing fibroblast and smooth muscle cell markers. In vitro and in vivo assays demonstrated that EPDCs secreted paracrine factors that strongly promoted angiogenesis. In a myocardial infarction model, EPDC-conditioned medium reduced infarct size and improved heart function. Our findings indicate that epicardium modulates the cardiac injury response by conditioning the subepicardial environment, potentially offering a new therapeutic strategy for cardiac protection.
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1 retracted
Angiogenesis by Implantation of Peripheral Blood Mononuclear Cells and Platelets Into Ischemic Limbs
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Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
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A myocardial lineage derives from Tbx18 epicardial cells
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Cited by
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Litviňuková, M., Talavera-López, C., Maatz, H., Reichart, D., Worth, C. L., Lindberg, E. L., Kanda, M., Polanski, K., Heinig, M., Lee, M., et al. (2020) · Nature · doi:10.1038/s41586-020-2797-4 · Cited by 1,729
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Self-citationResident fibroblast lineages mediate pressure overload–induced cardiac fibrosis
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Self-citationRedefining the identity of cardiac fibroblasts
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Metadata
- Authors
- Zhou, B., Honor, L. B., He, H., Ma, Q., Oh, J.-H., Butterfield, C., Lin, R.-Z., Melero-Martin, J. M., Dolmatova, E., Duffy, H. S., Gise, A. V., Zhou, P., Hu, Y. W., Wang, G., Zhang, B., Wang, L., Hall, J. L., Moses, M. A., McGowan, F. X., & Pu, W. T.
- Venue
- Journal of Clinical Investigation
- Published
- 2011-05-02
- Volume
- 121
- Issue
- 5
- Pages
- 1894-1904
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2132562087
- Cited by
- 517
- References
- 39
- FWCI
- 14.46
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhou, B., Honor, L. B., He, H., Ma, Q., Oh, J.-H., Butterfield, C., Lin, R.-Z., Melero-Martin, J. M., Dolmatova, E., Duffy, H. S., Gise, A. V., Zhou, P., Hu, Y. W., Wang, G., Zhang, B., Wang, L., Hall, J. L., Moses, M. A., McGowan, F. X., & Pu, W. T. (2011). Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. Journal of Clinical Investigation. https://doi.org/10.1172/jci45529
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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