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Evidence for altered synthesis of type II collagen in patients with osteoarthritis.
Open accessAbstract
There is evidence to suggest that the synthesis of type II collagen is increased in osteoarthritis (OA). Using an immunoassay, we show that the content of the C-propeptide of type II procollagen (CPII), released extracellularly from the newly synthesized molecule, is directly related to the synthesis of this molecule in healthy and osteoarthritic articular cartilages. In OA cartilage, CPII content is often markedly elevated (mean 7.6-fold), particularly in the mid and deep zones, reaching 29.6% of the content in newborn. Synthesis is also directly related to total collagen II content in OA, suggesting its importance in maintaining collagen content and cartilage structure. The release of CPII from cartilage is correlated directly with cartilage content. However, the increase in CPII in OA cartilage is not reflected in serum, where a significant reduction is observed. Together these studies provide evidence for alterations in procollagen II synthesis in vivo in patients with OA.
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Cited by
Extracellular Matrix Molecules: Potential Targets in Pharmacotherapy
Järveläinen, H., Sainio, A., Koulu, M., Wight, T. N., & Penttinen, R. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001289 · Cited by 566
535 East 70th Street, C. R. B., Goldring, M., Otero, M., Plumb, D., Dragomir, C., Favero, M., EI Hachem, K., Hashimoto, K., Roach, H., Olivotto, E., et al. (2011) · European Cells and Materials · doi:10.22203/ecm.v021a16 · Cited by 489
Garnero, P., Ayral, X., Rousseau, J., Christgau, S., Sandell, L. J., Dougados, M., & Delmas, P. D. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10576 · Cited by 398
Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis
Kraus, V. B., Burnett, B., Coindreau, J., Cottrell, S., Eyre, D., Gendreau, M., Gardiner, J., Garnero, P., Hardin, J., Henrotin, Y., et al. (2011) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2010.08.019 · Cited by 328
Self-citationLohmander, L. S., Atley, L. M., Pietka, T. A., & Eyre, D. R. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11326 · Cited by 263
Metadata
- Authors
- Nelson, F., Dahlberg, L., Laverty, S., Reiner, A., Pidoux, I., Ionescu, M., Fraser, G. L., Brooks, E., Tanzer, M., Rosenberg, L. C., Dieppe, P., & Robin Poole, A.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-12-15
- Volume
- 102
- Issue
- 12
- Pages
- 2115-2125
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2081563776
- Cited by
- 298
- References
- 0
- FWCI
- 4.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Evidence for altered synthesis of type II collagen in patients with osteoarthritis. https://app.cochat.ai/papers/10.1172/jci4853
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- Nelson, F., Dahlberg, L., Laverty, S., Reiner, A., Pidoux, I., Ionescu, M., Fraser, G. L., Brooks, E., Tanzer, M., Rosenberg, L. C., Dieppe, P., & Robin Poole, A. (1998). Evidence for altered synthesis of type II collagen in patients with osteoarthritis. Journal of Clinical Investigation. https://doi.org/10.1172/jci4853
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
