Cited by 197Hypothalamic control of reproductive hormonesReproductive Biology and FertilityRegulation of Appetite and Obesity

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Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration

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Sonigo, Charlotte, Bouilly, Justine, Carré, Nadège, Tolle, Virginie, Caraty, Alain, Tello, Javier, Simony-Conesa, Fabian-Jesus, Millar, Robert, Young, Jacques, Binart, Nadine·2012·Journal of Clinical Investigation

DOI 10.1172/jci63937PMC PMC3461919

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Abstract

Hyperprolactinemia is the most common cause of hypogonadotropic anovulation and is one of the leading causes of infertility in women aged 25-34. Hyperprolactinemia has been proposed to block ovulation through inhibition of GnRH release. Kisspeptin neurons, which express prolactin receptors, were recently identified as major regulators of GnRH neurons. To mimic the human pathology of anovulation, we continuously infused female mice with prolactin. Our studies demonstrated that hyperprolactinemia in mice induced anovulation, reduced GnRH and gonadotropin secretion, and diminished kisspeptin expression. Kisspeptin administration restored gonadotropin secretion and ovarian cyclicity, suggesting that kisspeptin neurons play a major role in hyperprolactinemic anovulation. Our studies indicate that administration of kisspeptin may serve as an alternative therapeutic approach to restore the fertility of hyperprolactinemic women who are resistant or intolerant to dopamine agonists.

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Authors: Sonigo, C., Bouilly, J., Carré, N., Tolle, V., Caraty, A., Tello, J., Simony-Conesa, F.-J., Millar, R., Young, J., & Binart, N.
Affiliations: Université Paris-Sud (FR)
Inserm (FR)
Centre National de la Recherche Scientifique (FR)
University of Edinburgh (GB)
University of Cape Town (ZA)
Corresponding author: Binart, Nadine
ORCID: Sonigo, Charlotte
Tolle, Virginie
Tello, Javier
Millar, Robert
Young, Jacques
Binart, Nadine
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2012-10-01
Volume: 122
Issue: 10
Pages: 3791-3795
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci63937
PMC: PMC3461919
OpenAlex: W2161243079
Cited by: 197
References: 24
Citations by year: 2026: 8 · 2025: 14 · 2024: 19 · 2023: 15 · 2022: 21 · 2021: 10 · 2020: 15 · 2019: 20 · 2018: 15 · 2017: 17 · 2016: 10 · 2015: 8 · 2014: 8 · 2013: 13 · 2012: 2
FWCI: 11.55
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
UpSpace Institutional Repository (University of Pretoria) (submittedVersion)
Funders: University of Pretoria
Fondation pour la Recherche Médicale
Medical Research Council
Topics: Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Reproductive Medicine › Reproductive Biology and Fertility
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords: hyperprolactinemia, kisspeptin, anovulation, GnRH neurons, prolactin receptor, gonadotropin secretion, female infertility, dopamine agonist resistance, kisspeptin neurons
MeSH terms: Animals, Anovulation, Disease Models, Animal, Drug Evaluation, Preclinical, Female, Gene Expression Regulation, Gonadotropins, Pituitary, Hyperprolactinemia, Hypothalamo-Hypophyseal System, Hypothalamus, Gonadotropin-Releasing Hormone, Male, Prolactin, Pulsatile Flow, RNA, Messenger, Infusion Pumps, Implantable, Estrous Cycle, Mice, Kisspeptins

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Hyperprolactinemia-induced ovarian acyclicity is reversed by kisspeptin administration

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