Harnessing FOXP3+ regulatory T cells for transplantation tolerance
Open accessAbstract
Early demonstrations that mice could be tolerized to transplanted tissues with short courses of immunosuppressive therapy and that with regard to tolerance to self, CD4+FOXP3+ regulatory T cells (Tregs) appeared to play a critical role, have catalyzed strategies to harness FOXP3-dependent processes to control rejection in human transplantation. This review seeks to examine the scientific underpinning for this new approach to finesse immunosuppression.
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Regulatory T cells restrain inflammation in the graft by inhibiting entry of effector T cells, an important mechanism for inducing graft tolerance.
“regulatory T (Treg) cells restrain the inflammation in the graft by inhibiting the entry of effector T cells into the graft, which have been identified as an important mechanism for inducing graft tolerance37,38.”
From Bioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation (2023) · cites this paper as [37]
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References 110 · Cited by 69
- Authors
- Waldmann, H., Hilbrands, R., Howie, D., & Cobbold, S.
- Affiliations
- University of Oxford (GB)
- Corresponding author
- Waldmann, Herman
- Venue
- Journal of Clinical Investigation
- Published
- 2014-04-01
- Volume
- 124
- Issue
- 4
- Pages
- 1439-1445
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC3973097
- OpenAlex
- W2094284801
- Cited by
- 69
- References
- 110
- Citations by year
- 2026: 4 · 2024: 5 · 2023: 5 · 2022: 3 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 5 · 2017: 6 · 2016: 10 · 2015: 10 · 2014: 5
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- VUBIR (Vrije Universiteit Brussel) (submittedVersion)
- Funders
- European Molecular Biology Organization
- University of Oxford
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Keywords
- Foxp3+ regulatory T cells, transplantation tolerance, immunosuppression, graft rejection, CD4+ T cells, self-tolerance, tolerance induction, transplantation immunology
- MeSH terms
- Animals, Humans, Immunosuppression Therapy, Receptors, Antigen, T-Cell, Signal Transduction, Transplantation Tolerance, Epigenesis, Genetic, T-Lymphocytes, Regulatory, Mice, Forkhead Transcription Factors
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