Cited by 318Sepsis Diagnosis and TreatmentInflammation biomarkers and pathwaysBacterial biofilms and quorum sensing

The DOI matches its Crossref record; 35 of the 36 references it cites were found in a registry or an index.

Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia

Open access

Kurahashi, Kiyoyasu, Kajikawa, Osamu, Sawa, Teiji, Ohara, Maria, Gropper, Michael A., Frank, Dara W., Martin, Thomas R., Wiener-Kronish, Jeanine P.·1999·Journal of Clinical Investigation

DOI 10.1172/jci7124PMC PMC408437

Open this paper in CoChat — free account Open PDF

Abstract

The pathogenesis of septic shock occurring after Pseudomonas aeruginosa pneumonia was studied in a rabbit model. The airspace instillation of the cytotoxic P. aeruginosa strain PA103 into the rabbit caused a consistent alveolar epithelial injury, progressive bacteremia, and septic shock. The lung instillation of a noncytotoxic, isogenic mutant strain (PA103DeltaUT), which is defective for production of type III secreted toxins, did not cause either systemic inflammatory response or septic shock, despite a potent inflammatory response in the lung. The intravenous injection of PA103 did not cause shock or an increase in TNF-alpha, despite the fact that the animals were bacteremic. The systemic administration of either anti-TNF-alpha serum or recombinant human IL-10 improved both septic shock and bacteremia in the animals that were instilled with PA103. Radiolabeled TNF-alpha instilled in the lung significantly leaked into the circulation only in the presence of alveolar epithelial injury. We conclude that injury to the alveolar epithelium allows the release of proinflammatory mediators into the circulation that are primarily responsible for septic shock. Our results demonstrate the importance of compartmentalization of inflammatory mediators in the lung, and the crucial role of bacterial cytotoxins in causing alveolar epithelial damage in the pathogenesis of acute septic shock in P. aeruginosa pneumonia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci7124

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The Pathophysiology of Tumor Necrosis Factors
VASSALLI, P. (1992) · Annual Review of Immunology · doi:10.1146/annurev.iy.10.040192.002211 · Cited by 1,874
A highly sensitive cell line, WEHI 164 clone 13, for measuring cytotoxic factor/tumor necrosis factor from human monocytes
Espevik, T., & Nissen-Meyer, J. (1986) · Journal of Immunological Methods · doi:10.1016/0022-1759(86)90322-4 · Cited by 1,256
Septic Shock in Humans
Parrillo, J. E., Parker, M. M., Natanson, C., Suffredini, A. F., Danner, R. L., Cunnion, R. E., & Ognibene, F. P. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-3-227 · Cited by 1,188
Nosocomial pneumonia in ventilated patients: A cohort study evaluating attributable mortality and hospital stay
Fagon, J.-Y., Chastre, J. E., Hance, A. J., Montravers, P., Novara, A., & Gibert, C. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90060-3 · Cited by 1,175
Incidence, Risk, and Prognosis Factors of Nosocomial Pneumonia in Mechanically Ventilated Patients
Torres, A., Aznar, R., Gatell, J. M., Jiménez, P., González, J., Ferrer, A., Celis, R., & Rodriguez‐Roisin, R. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.3.523 · Cited by 913
TUMOR NECROSIS, CACHEXIA, SHOCK, AND INFLAMMATION: A COMMON MEDIATOR
Beutler, B., & Cerami, A. (1988) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.57.070188.002445 · Cited by 805
Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via strontium phosphate coprecipitation with a plasmid containing SV40 early region genes.
Reddel, R. R., Ke, Y., Gerwin, B. I., McMenamin, M. G., Lechner, J. F., Su, R., Brash, D. E., Park, J. B., Rhim, J. S., & Harris, C. C. (1988) · PubMed · Cited by 783
Clinical predictors of the adult respiratory distress syndrome
Pepe, P. E., Potkin, R. T., Reus, D. H., Hudson, L. D., & Carrico, C. J. (1982) · The American Journal of Surgery · doi:10.1016/0002-9610(82)90612-2 · Cited by 687
Inflammatory Cytokines in Patients With Persistence of the Acute Respiratory Distress Syndrome
Goodman, R. B., Strieter, R. M., Martin, D. P., Steinberg, K. P., MILBERG, J. A., Maunder, R. J., Kunkel, S. L., Walz, A., Hudson, L. D., & Martin, T. R. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.154.3.8810593 · Cited by 528
Self-citation
ExoU expression by Pseudomonas aeruginosa correlates with acute cytotoxicity and epithelial injury
Finck‐Barbançon, V., Goranson, J., Zhu, L., Sawa, T., Wiener‐Kronish, J. P., Fleiszig, S. M. J., Wu, C. C., Mende‐Mueller, L., & Frank, D. W. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.4891851.x · Cited by 518
Self-citation

Flagged first, then by citations

Show all 36 references

1 of the 36 references couldn’t be matched to a known paper.

Research works printed but not linked: 6

Rouby, 1996, Semin Respir Infect, 11, 54
Craven, 1996, Semin Respir Infect, 11, 32
Sawa, 1998, Infect Immun, 65, 579
Kudoh, 1994, Am J Physiol, 267, L551
Reddel, 1988, Cancer Res, 48, 1904
Wiener-Kronish, 1991, J Clin Invest, 88, 864, 10.1172/JCI115388 · DOI

Sorted by citations

Items 101–200 of 318

Short term Candida albicans colonization reduces Pseudomonas aeruginosa-related lung injury and bacterial burden in a murine model
Ader, F., Jawhara, S., Nseir, S., Kipnis, É., Faure, K., Vuotto, F., Chemani, C., Sendid, B., Poulain, D., & Guery, B. P. (2011) · Critical Care · doi:10.1186/cc10276 · Cited by 64
A C-Terminal Domain Targets the Pseudomonas aeruginosa Cytotoxin ExoU to the Plasma Membrane of Host Cells
Rabin, S. D. P., Veesenmeyer, J. L., Bieging-Rolett, K. T., & Hauser, A. R. (2006) · Infection and Immunity · doi:10.1128/iai.74.5.2552-2561.2006 · Cited by 57
Functional Domains of ExsA, the Transcriptional Activator of the Pseudomonas aeruginosa Type III Secretion System
Brutinel, E. D., Vakulskas, C. A., & Yahr, T. L. (2009) · Journal of Bacteriology · doi:10.1128/jb.00002-09 · Cited by 56
Use of some pre-, pro- and synbiotics in critically ill patients
Bengmark, S. (2003) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/s1521-6918(03)00073-8 · Cited by 57
Role of Toll Interleukin-1 Receptor (IL-1R) 8, a Negative Regulator of IL-1R/Toll-Like Receptor Signaling, in Resistance to Acute Pseudomonas aeruginosa Lung Infection
Rodríguez, T. V., Moalli, F., Polentarutti, N., Paroni, M., Bonavita, E., Anselmo, A., Nebuloni, M., Mantero, S., Jaillon, S., Bragonzi, A., et al. (2011) · Infection and Immunity · doi:10.1128/iai.05695-11 · Cited by 54
Sepsis, Severe Sepsis, and Septic Shock
Munford, R. S., & Suffredini, A. F. (2010) · Elsevier eBooks · doi:10.1016/b978-0-443-06839-3.00070-9 · Cited by 55
Virulence Factors in
van Delden, C. (2004) · Springer eBooks · doi:10.1007/978-1-4419-9084-6_1 · Cited by 54
Compartmentalisation of cytokines and cytokine inhibitors in ventilator-associated pneumonia
Millo, J. L., Schultz, M. J., Williams, C., Weverling, G. J., Ringrose, T., Mackinlay, C. I., van der Poll, T., & Garrard, C. S. (2004) · Intensive Care Medicine · doi:10.1007/s00134-003-2060-0 · Cited by 54
Endotoxin causes functional endoplasmic reticulum failure, possibly mediated by mitochondria
Kozlov, A. V., Duvigneau, J. C., Miller, I., Nürnberger, S., Gesslbauer, B., Kungl, A. J., Öhlinger, W., Hartl, R. T., Gille, L., Staniek, K., et al. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.03.004 · Cited by 54
Fingerprint Analysis and Identification of Strains ST309 as a Potential High Risk Clone in a Pseudomonas aeruginosa Population Isolated from Children with Bacteremia in Mexico City
Morales-Espinosa, R., Delgado, G., Espinosa-Camacho, L. F., Isselo, D., Mendez, J. L., Rodríguez, C., Miranda-Novales, M. G., & Cravioto, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00313 · Cited by 50
Experimental Models and Emerging Hypotheses for Acute Lung Injury
Martin, T. R., & Matute‐Bello, G. (2011) · Critical Care Clinics · doi:10.1016/j.ccc.2011.05.013 · Cited by 51
Self-citation
Evolution of Pseudomonas aeruginosa type III secretion in cystic fibrosis: a paradigm of chronic infection
Jain, M., Bar‐Meir, M., McColley, S. A., Cullina, J. F., Potter, E., Powers, C., Prickett, M. H., SESHADRI, R. M., Jovanovic, B., Petrocheilou, A., et al. (2008) · Translational research · doi:10.1016/j.trsl.2008.10.003 · Cited by 50
O-Antigen Serotypes and Type III Secretory Toxins in Clinical Isolates of Pseudomonas aeruginosa
Faure, K., Shimabukuro, D. W., Ajayi, T., Allmond, L. R., Sawa, T., & Wiener-Kronish, J. P. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.5.2158-2160.2003 · Cited by 50
Self-citation
The proinflammatory role of HECTD2 in innate immunity and experimental lung injury
Coon, T. A., McKelvey, A. C., Lear, T., Rajbhandari, S., Dunn, S. R., Connelly, W., Zhao, J. Y., Han, S., Liu, Y., Weathington, N. M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab3881 · Cited by 49
Pseudomonas aeruginosa Exotoxin Y-Mediated Tau Hyperphosphorylation Impairs Microtubule Assembly in Pulmonary Microvascular Endothelial Cells
Balczon, R., Prasain, N., Ochoa, C. D., Prater, J., Zhu, B., ALEXEYEV, M. F., Sayner, S., Frank, D. W., & Stevens, T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074343 · Cited by 53
Self-citation
PROTECTION AGAINST PSEUDOMONAS AERUGINOSA PNEUMONIA AND SEPSIS-INDUCED LUNG INJURY BY OVEREXPRESSION of β-DEFENSIN-2 IN RATS
Shu, Q., Shi, Z., Zhao, Z., Chen, Z. J., Yao, H., Chen, Q., Hoeft, A., Stüber, F., & Fang, X. (2006) · Shock · doi:10.1097/01.shk.0000224722.65929.58 · Cited by 47
Novel strategies to combat bacterial virulence
Lynch, S. V., & Wiener-Kronish, J. P. (2008) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e32830f1dd5 · Cited by 47
Self-citation
Alveolar Response toPseudomonas aeruginosa: Role of the Type III Secretion System
Ader, F., Berre, R. L., Faure, K., Gosset, P., Épaulard, O., Toussaint, B., Polack, B., Nowak, E., Viget, N. B., Kipnis, É., et al. (2005) · Infection and Immunity · doi:10.1128/iai.73.7.4263-4271.2005 · Cited by 46
KL-6 concentration in pulmonary epithelial lining fluid is a useful prognostic indicator in patients with acute respiratory distress syndrome
Kondo, T., Hattori, N., Ishikawa, N., Murai, H., Haruta, Y., Hirohashi, N., Tanigawa, K., & Kohno, N. (2011) · Respiratory Research · doi:10.1186/1465-9921-12-32 · Cited by 46
Lipid body mobilization in the ExoU-induced release of inflammatory mediators by airway epithelial cells
Plotkowski, M. C., Brandão, B. A., Assis, M.-C., Feliciano, L.-F. P., Raymond, B., de Freitas, C. S., Saliba, A. M., Zahm, J., Touqui, L., & Bozza, P. T. (2008) · Microbial Pathogenesis · doi:10.1016/j.micpath.2008.01.008 · Cited by 45
The Type III Pseudomonal Exotoxin U Activates the c-Jun NH2-Terminal Kinase Pathway and Increases Human Epithelial Interleukin-8 Production
Cuzick, A., Stirling, F. R., Lindsay, S. L., & Evans, T. J. (2006) · Infection and Immunity · doi:10.1128/iai.02045-05 · Cited by 44
Type III secretion-mediated killing of endothelial cells by Pseudomonas aeruginosa
Saliba, A. M., Filloux, A., Ball, G., Silva, A. S. V., Assis, M.-C., & Plotkowski, M.-C. (2002) · Microbial Pathogenesis · doi:10.1006/mpat.2002.0522 · Cited by 44
Targeting of Pseudomonas aeruginosa in the Bloodstream with Bispecific Monoclonal Antibodies
Lindorfer, M. A., Nardin, A., Foley, P. L., Solga, M. D., Bankovich, A. J., Martin, E. N., Henderson, A. L., Price, C. W., Gyimesi, E., Wozencraft, C. P., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.4.2240 · Cited by 43
Protective effects of low tidal volume ventilation in a rabbit model of Pseudomonas aeruginosa-induced acute lung injury
Savel, R. H., Yao, E. C., & Gropper, M. A. (2001) · Critical Care Medicine · doi:10.1097/00003246-200102000-00032 · Cited by 41
Self-citation
Stimulation of innate immunity by susceptible and multidrug-resistant Pseudomonas aeruginosa: an in vitro and in vivo study
Giamarellos‐Bourboulis, E. J., Plachouras, D., TZIVRA, A., Koussoulas, V., Bolanos, N., Raftogiannis, M., Galani, I., Dontas, I. A., Dionyssiou‐Asteriou, A., & Giamarellou, H. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2003.02365.x · Cited by 42
Phase behavior of ternary mannosylerythritol lipid/water/oil systems
Worakitkanchanakul, W., Imura, T., Fukuoka, T., Morita, T., Sakai, H., Abe, M., Rujiravanit, R., Chavadej, S., Minamikawa, H., & Kitamoto, D. (2008) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2008.10.009 · Cited by 42
Protein Binding between PcrG-PcrV and PcrH-PopB/PopD Encoded by thepcrGVH-popBDOperon of thePseudomonas aeruginosaType III Secretion System
Allmond, L. R., Karaca, T. J., Nguyen, V. N., Nguyen, T. T., Wiener-Kronish, J. P., & Sawa, T. (2003) · Infection and Immunity · doi:10.1128/iai.71.4.2230-2233.2003 · Cited by 42
Self-citation
Severe Bacteremia Results in a Loss of Hepatic Bacterial Clearance
Ashare, A., Monick, M. M., Powers, L. S., Yarovinsky, T. O., & Hunninghake, G. W. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200509-1470oc · Cited by 42
Fitness Cost of Fluoroquinolone Resistance in Clinical Isolates of Pseudomonas aeruginosa Differs by Type III Secretion Genotype
Agnello, M., Finkel, S. E., & Wong‐Beringer, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01591 · Cited by 41
PLGA-encapsulation of the Pseudomonas aeruginosa PopB vaccine antigen improves Th17 responses and confers protection against experimental acute pneumonia
Schaefers, M., Duan, B., Mizrahi, B., Lu, R., Reznor, G., Kohane, D. S., & Priebe, G. P. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.10.010 · Cited by 40
Type III Secretion-Dependent Modulation of Innate Immunity as One of Multiple Factors Regulated byPseudomonas aeruginosaRetS
Zolfaghar, I., Evans, D. J., Ronaghi, R., & Fleiszig, S. M. J. (2006) · Infection and Immunity · doi:10.1128/iai.01891-05 · Cited by 40
Polymorphisms in the Pseudomonas aeruginosa type III secretion protein, PcrV – Implications for anti-PcrV immunotherapy
Lynch, S. V., Flanagan, J., Sawa, T., Fang, A., Baek, M. S., Rubio-Mills, A., Ajayi, T., Yanagihara, K., Hirakata, Y., Kohno, S., et al. (2010) · Microbial Pathogenesis · doi:10.1016/j.micpath.2010.02.008 · Cited by 40
Self-citation
Increased Plasminogen Activator Inhibitor-1 Concentrations in Bronchoalveolar Lavage Fluids Are Associated with Increased Mortality in a Cohort of Patients with Pseudomonas aeruginosa
Song, Y., Lynch, S. V., Flanagan, J., Zhuo, H., Tom, W., Dotson, R. H., Baek, M. S., Rubio-Mills, A., Singh, G., Kipnis, É., et al. (2007) · Anesthesiology · doi:10.1097/00000542-200702000-00012 · Cited by 40
Self-citation
Perspectives on the Pseudomonas aeruginosa Type III Secretion System Effector ExoU and Its Subversion of the Host Innate Immune Response to Infection
Hardy, K. S., Tessmer, M. H., Frank, D. W., & Audia, J. P. (2021) · Toxins · doi:10.3390/toxins13120880 · Cited by 41
Self-citation
Multidrug resistant (or antimicrobial-resistant) pathogens - alternatives to new antibiotics?
Brunel, A.-S., & Guery, B. P. (2017) · Swiss Medical Weekly · doi:10.4414/smw.2017.14553 · Cited by 40
Compartmentalization of the inflammatory response in sepsis and SIRS
Cavaillon, J., & Annane, D. (2006) · Journal of Endotoxin Research · doi:10.1177/09680519060120030301 · Cited by 248
Risk factors for mortality in patients with bloodstream infections caused by carbapenem-resistant Pseudomonas aeruginosa: clinical impact of bacterial virulence and strains on outcome
Jeong, S. J., Yoon, S. S., Bae, I. K., Jeong, S. H., Kim, J. M., & Lee, K. (2014) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2014.07.003 · Cited by 38
Assessment and Care of the Critically Ill Rabbit
Huynh, M., Boyeaux, A., & Pignon, C. (2016) · Veterinary Clinics of North America Exotic Animal Practice · doi:10.1016/j.cvex.2016.01.011 · Cited by 38
Is Severe Sepsis a Neuroendocrine Disease?
Munford, R. S., & Tracey, K. J. (2002) · Molecular Medicine · doi:10.1007/bf03402023 · Cited by 37
Role of Small GTPases and αvβ5 Integrin in Pseudomonas aeruginosa –Induced Increase in Lung Endothelial Permeability
Ganter, M. T., Roux, J., Su, G., Lynch, S. V., Deutschman, C. S., Weiss, Y., Christiaans, S. C., Myazawa, B., Kipnis, É., Wiener-Kronish, J. P., et al. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0454oc · Cited by 37
Self-citation
Pseudomonas aeruginosa Exolysin promotes bacterial growth in lungs, alveolar damage and bacterial dissemination
Bouillot, S., Munro, P. M., Gallet, B., Reboud, E., Cretin, F. C., Golovkine, G. R., Schoehn, G., Attrée, I., Lemichez, E., & Huber, P. (2017) · Scientific Reports · doi:10.1038/s41598-017-02349-0 · Cited by 36
Virulence attenuating combination therapy: a potential multi-target synergy approach to treat Pseudomonas aeruginosa infections in cystic fibrosis patients
Shaw, E. R., & Wuest, W. M. (2020) · RSC Medicinal Chemistry · doi:10.1039/c9md00566h · Cited by 36
Tumor necrosis factor (TNF) and lymphotoxin-alpha (LTA) single nucleotide polymorphisms: Importance in ARDS in septic pediatric critically ill patients
de Azevedo, Z. M. A., Moore, D. B., Lima, F., Cardoso, C. C., Bougleux, R., Matos, G. I., Luz, R. A., Xavier‐Elsas, P., Sampaio, E. P., Elsas, M., et al. (2012) · Human Immunology · doi:10.1016/j.humimm.2012.03.007 · Cited by 35
Thrombomodulin Improved Liver Injury, Coagulopathy, and Mortality in an Experimental Heatstroke Model in Mice
Kawasaki, T., Okamoto, K., Kawasaki, C., & Sata, T. (2014) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000000170 · Cited by 35
Anti-inflammatory effect of aldose reductase inhibition in murine polymicrobial sepsis
Reddy, A. B. M., Srivastava, S. K., & Ramana, K. V. (2009) · Cytokine · doi:10.1016/j.cyto.2009.07.004 · Cited by 35
In a murine model of acute lung infection, airway administration of a therapeutic antibody confers greater protection than parenteral administration
Sécher, T., Dalloneau, E., Ferreira, M., Parent, C., Azzopardi, N., Paintaud, G., Si‐Tahar, M., & Heuzé‐Vourc'h, N. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.04.005 · Cited by 34
EXOU-INDUCED VASCULAR HYPERPERMEABILITY AND PLATELET ACTIVATION IN THE COURSE OF EXPERIMENTAL PSEUDOMONAS AERUGINOSA PNEUMOSEPSIS
Machado, G.-B., Assis, M.-C., Leão, R. S., Saliba, A. M., da Silva, M. C. A., Suassuna, J. H. R., OLIVEIRA, A. V. D., & Plotkowski, M. C. (2010) · Shock · doi:10.1097/shk.0b013e3181b2b0f4 · Cited by 34
We should be measuring genomic bacterial load and virulence factors
Lisboa, T. C., WATERER, G. W., & Rello, J. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181f2453a · Cited by 34
Catheter-associated urinary tract infection by Pseudomonas aeruginosa progresses through acute and chronic phases of infection
Mekonnen, S. A., Husseini, N. E., Turdiev, A., Carter, J. A., Belew, A. T., El-Sayed, N. M., & Lee, V. T. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209383119 · Cited by 33
Depletion of phagocytes in the reticuloendothelial system causes increased inflammation and mortality in rabbits withPseudomonas aeruginosapneumonia
Kurahashi, K., Sawa, T., Ota, M., Kajikawa, O., Hong, K., Martin, T. R., & Wiener-Kronish, J. P. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90472.2008 · Cited by 33
Self-citation
Impact of IL-10 on Diaphragmatic Cytokine Expression and Contractility during Pseudomonas Infection
Divangahi, M., Demoule, A., Danialou, G., Yahiaoui, L., Bao, W., Xing, Z., & Petrof, B. J. (2006) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2006-0038oc · Cited by 33
Ventilator-induced lung injury, cytokines, PEEP, and mortality: implications for practice and for clinical trials
Slutsky, A. S., & Imai, Y. (2003) · Intensive Care Medicine · doi:10.1007/s00134-003-1793-0 · Cited by 33
Circulating immune parameters predicting the progression from hospital-acquired pneumonia to septic shock in surgical patients
von Dossow, V., Rotard, K., Redlich, U., Hein, O. V., & Spies, C. (2005) · Critical Care · doi:10.1186/cc3826 · Cited by 33
Synergistic Therapeutic Potential of Dexamethasone and l-arginine in Lipopolysaccharide-Induced Septic Shock
Chatterjee, S., Premachandran, S., Shukla, J., & Poduval, T. B. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.09.002 · Cited by 31
Early Growth Response 1 Deficiency Protects the Host against Pseudomonas aeruginosa Lung Infection
Pang, Z., Raudonis, R., McCormick, C., & Cheng, Z. (2019) · Infection and Immunity · doi:10.1128/iai.00678-19 · Cited by 31
The Systemic Response to Lung Infection
Deng, J. C., & Standiford, T. J. (2005) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2004.10.009 · Cited by 31
Protection with Antibody to Tumor Necrosis Factor Differs with Similarly Lethal Escherichia coli versus Staphylococcus aureus Pneumonia in Rats
Karzai, W., Cui, X., Mehlhorn, B., Straube, E., Härtung, T., Gerstenberger, E. P., Banks, S. M., Natanson, C., Reinhart, K., & Eichacker, P. Q. (2003) · Anesthesiology · doi:10.1097/00000542-200307000-00016 · Cited by 31
Diversity of Virulence Phenotypes among Type III Secretion Negative Pseudomonas aeruginosa Clinical Isolates
Toska, J., Sun, Y., Carbonell, D. A., Foster, A. N., Jacobs, M. R., Pearlman, E. M., & Rietsch, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086829 · Cited by 30
In the Absence of Effector Proteins, the Pseudomonas aeruginosa Type Three Secretion System Needle Tip Complex Contributes to Lung Injury and Systemic Inflammatory Responses
Audia, J. P., Lindsey, A. S., Housley, N. A., Ochoa, C. R., Zhou, C., Toba, M., Oka, M., Annamdevula, N. S., Fitzgerald, M. S., Frank, D. W., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081792 · Cited by 30
Self-citation
The protective effects of nasal PcrV‐CpG oligonucleotide vaccination against Pseudomonas aeruginosa pneumonia
Naito, Y., Hamaoka, S., Kinoshita, M., Kainuma, A., Shimizu, M., Katoh, H., Moriyama, K., Ishii, K. J., & Sawa, T. (2018) · Microbiology and Immunology · doi:10.1111/1348-0421.12658 · Cited by 30
Self-citation
IV Immunoglobulin for Acute Lung Injury and Bacteremia in Pseudomonas aeruginosa Pneumonia*
Katoh, H., Yasumoto, H., Shimizu, M., Hamaoka, S., Kinoshita, M., Akiyama, K., & Sawa, T. (2015) · Critical Care Medicine · doi:10.1097/ccm.0000000000001271 · Cited by 29
Self-citation
Bacterial Penetration of the Mucosal Barrier by Targeting Lipid Rafts
Abraham, S. N., Duncan, M. J., Li, G., & Zaas, D. (2005) · Journal of Investigative Medicine · doi:10.2310/6650.2005.53609 · Cited by 29
Cytokine Release Following Recruitment Maneuvers
Talmor, D. S., Sarge, T., Legedza, A., O’Donnell, C. R., Ritz, R., Loring, S. H., & Malhotra, A. (2007) · CHEST Journal · doi:10.1378/chest.07-1551 · Cited by 28
Molecular epidemiology of clinically high‐risk Pseudomonas aeruginosa strains: Practical overview
Sawa, T., Momiyama, K., Mihara, T., Kainuma, A., Kinoshita, M., & Moriyama, K. (2020) · Microbiology and Immunology · doi:10.1111/1348-0421.12776 · Cited by 28
Self-citation
ExoY, an actin-activated nucleotidyl cyclase toxin from P. aeruginosa: A minireview
Belyy, A., Mechold, U., Renault, L., & Ladant, D. (2017) · Toxicon · doi:10.1016/j.toxicon.2017.12.046 · Cited by 27
High pyocyanin production and non-motility of Pseudomonas aeruginosa isolates are correlated with septic shock or death in bacteremic patients
Gupte, A. A., Jyot, J., Ravi, M., & Ramphal, R. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253259 · Cited by 27
The severity of shock is associated with impaired rates of net alveolar fluid clearance in clinical acute lung injury
Zeyed, Y. F., Bastarache, J. A., Matthay, M. A., & Ware, L. B. (2012) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00190.2012 · Cited by 27
IMAGING LUNG INFLAMMATION IN A MURINE MODEL OF PSEUDOMONAS INFECTION: A POSITRON EMISSION TOMOGRAPHY STUDY
Schuster, D. P., KOZLOWSKI, J. K., Hogue, L. A., & Ferkol, T. W. (2003) · Experimental Lung Research · doi:10.1080/01902140303760 · Cited by 27
Complications pulmonaires de la transfusion (TACO–TRALI)
Renaudier, P., Rebibo, D., Waller, C., Schlanger, S., Mai, M.-P. V., Ounnoughene, N., Breton, P., Chèze, S., Girard, A., Hauser, L., et al. (2009) · Transfusion Clinique et Biologique · doi:10.1016/j.tracli.2009.04.008 · Cited by 26
The Role of Pseudomonas aeruginosa Virulence Factors in Cytoskeletal Dysregulation and Lung Barrier Dysfunction
Wagener, B. M., Hu, R.-H., Wu, S., Pittet, J., Ding, Q., & Che, P. (2021) · Toxins · doi:10.3390/toxins13110776 · Cited by 26
Genome-wide analysis of host responses to the Pseudomonas aeruginosa type III secretion system yields synergistic effects
Ichikawa, J. K., English, S. B., Wolfgang, M. C., Jackson, R., Butte, A. J., & Lory, S. (2005) · Cellular Microbiology · doi:10.1111/j.1462-5822.2005.00581.x · Cited by 29
The effects ofEscherichia colicapsule, O-antigen, host neutrophils, and complement in a rat model of Gram-negative pneumonia
Russo, T. A., Davidson, B. A., MacDonald, U., Helinski, J. D., Priore, R. L., & Knight, P. R. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00636-0 · Cited by 26
Evidence-Based Management of Critically Ill Patients: Analysis and Implementation
Gropper, M. A. (2004) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000123494.40145.b3 · Cited by 26
Self-citation
Pseudomonas aeruginosa Type III Secretory Toxin ExoU and Its Predicted Homologs
Sawa, T., Hamaoka, S., Kinoshita, M., Kainuma, A., Naito, Y., Akiyama, K., & Kato, H. (2016) · Toxins · doi:10.3390/toxins8110307 · Cited by 25
Self-citation
Valproic acid mitigates the inflammatory response and prevents acute respiratory distress syndrome in a murine model of Escherichia coli pneumonia at the expense of bacterial clearance
Kasotakis, G., Galvan, M. D., King, E. G., Sarkar, B., Stucchi, A. F., Mizgerd, J. P., Burke, P., & Remick, D. G. (2017) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000001389 · Cited by 25
Poly(ADP-ribose) polymerase-1 inhibition increases expression of heat shock proteins and attenuates heat stroke-induced liver injury
Mota, R., Hernández‐Espinosa, D., Galbis‐Martínez, L., Ordóñez, A., Miñano, A., Parrilla, P., Vicente, V., Corral, J., & Yélamos, J. (2008) · Critical Care Medicine · doi:10.1097/01.ccm.0000299735.43699.e9 · Cited by 25
High tidal volume ventilation induces lung injury after hepatic ischemia-reperfusion
Ota, S., Nakamura, K., Yazawa, T., Kawaguchi, Y., Baba, Y., Kitaoka, R., Morimura, N., Goto, T., Yamada, Y., & Kurahashi, K. (2006) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00151.2006 · Cited by 24
Self-citation
In Vitro Analysis of Pseudomonas aeruginosa Virulence Using Conditions That Mimic the Environment at Specific Infection Sites
Colmer‐Hamood, J. A., Dzvova, N., Kruczek, C. J., & Hamood, A. N. (2016) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2016.05.003 · Cited by 24
Efficacy comparison of adjuvants in PcrV vaccine against Pseudomonas aeruginosa pneumonia
Hamaoka, S., Naito, Y., Katoh, H., Shimizu, M., Kinoshita, M., Akiyama, K., Kainuma, A., Moriyama, K., Ishii, K. J., & Sawa, T. (2017) · Microbiology and Immunology · doi:10.1111/1348-0421.12467 · Cited by 24
Self-citation
Acidosis increases the susceptibility of respiratory epithelial cells toPseudomonas aeruginosa-induced cytotoxicity
Torres, I. M., Demirdjian, S., Vargas, J., Goodale, B. C., & Berwin, B. L. (2017) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00524.2016 · Cited by 23
Innate and Adaptive Immune Responses against Bordetella pertussis and Pseudomonas aeruginosa in a Murine Model of Mucosal Vaccination against Respiratory Infection
Blackwood, C. B., Sen-Kilic, E., Boehm, D. T., Hall, J. M., Varney, M. E., Wong, T. Y., Bradford, S. D., Bevere, J. R., Witt, W. T., Damron, F. H., et al. (2020) · Vaccines · doi:10.3390/vaccines8040647 · Cited by 21
Pseudomonas aeruginosa
Pier, G. B., & Ramphal, R. (2010) · Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases · doi:10.1016/b978-0-443-06839-3.00219-8 · Cited by 22
The Pseudomonas aeruginosa Type III Secretion System Exoenzyme Effector ExoU Induces Mitochondrial Damage in a Murine Bone Marrow-Derived Macrophage Infection Model
Hardy, K. S., Tuckey, A. N., Housley, N. A., Andrews, J., Patel, M., Al-Mehdi, A.-B., Barrington, R. A., Cassel, S. L., Sutterwala, F. S., & Audia, J. P. (2022) · Infection and Immunity · doi:10.1128/iai.00470-21 · Cited by 20
ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection
Hardy, K. S., Tuckey, A. N., Renema, P., Patel, M., Al‐Mehdi, A., Spadafora, D., Schlumpf, C. A., Barrington, R. A., ALEXEYEV, M. F., Stevens, T., et al. (2022) · Toxins · doi:10.3390/toxins14020152 · Cited by 21
Cytokines and lung injury: Searching for useful biomarkers*
Martin, T. R. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000150825.01762.90 · Cited by 20
Self-citation
Modulation of Cytosolic Ca 2+ Concentration in Airway Epithelial Cells by Pseudomonas aeruginosa
Jacob, T., Lee, R., Engel, J. N., & Machen, T. E. (2002) · Infection and Immunity · doi:10.1128/iai.70.11.6399-6408.2002 · Cited by 21
Distribution of the type III effector proteins-encoding genes among nosocomial Pseudomonas aeruginosa isolates from Bulgaria
Strateva, T., Markova, B., Ivanova, D., & Mitov, I. (2010) · Annals of Microbiology · doi:10.1007/s13213-010-0079-3 · Cited by 20
Effect of lung-protective ventilation on severePseudomonas aeruginosapneumonia and sepsis in rats
Kurahashi, K., Ota, S., Nakamura, K., Nagashima, Y., Yazawa, T., Satoh, M., Fujita, A., Kamiya, R., Fujita, E., Baba, Y., et al. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00435.2003 · Cited by 20
Self-citation
Evaluation of Pseudomonas aeruginosa pathogenesis and therapeutics in military‐relevant animal infection models
Bobrov, A. G., Getnet, D., Swierczewski, B. E., Jacobs, A. C., Medina‐Rojas, M., Tyner, S. D., Watters, C., & Antonic, V. (2021) · Apmis · doi:10.1111/apm.13119 · Cited by 19
Is Nuclear Factor Erythroid 2-Related Factor 2 a Target for the Intervention of Cytokine Storms?
Liu, Z., Deng, P., Liu, S., Bian, Y., Xu, Y., Zhang, Q., Wang, H., & Pi, J. (2023) · Antioxidants · doi:10.3390/antiox12010172 · Cited by 21
Orientation of Pseudomonas aeruginosa ExsA Monomers Bound to Promoter DNA and Base-Specific Contacts with the PexoT Promoter
King, J. M., Brutinel, E. D., Marsden, A. E., Schubot, F. D., & Yahr, T. L. (2012) · Journal of Bacteriology · doi:10.1128/jb.00107-12 · Cited by 19
Necrotizing Pseudomonas aeruginosa Community-Acquired Pneumonia: A Case Report and Review of the Literature
Maharaj, S. S., Isache, C. L., Seegobin, K., Chang, S., & Nelson, G. (2017) · Case Reports in Infectious Diseases · doi:10.1155/2017/1717492 · Cited by 19
A Disintegrin and Metalloproteinase—Control Elements in Infectious Diseases
Aljohmani, A., & Yildiz, D. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.608281 · Cited by 20
Acidosis Potentiates the Host Proinflammatory Interleukin-1β Response to Pseudomonas aeruginosa Infection
Torres, I. M., Patankar, Y. R., Shabaneh, T. B., Dolben, E. F., Hogan, D. A., Leib, D. A., & Berwin, B. L. (2014) · Infection and Immunity · doi:10.1128/iai.02024-14 · Cited by 18
Intricate relationship between SARS-CoV-2–induced shedding and cytokine storm generation: A signaling inflammatory pathway augmenting COVID-19
Moftah, M. B., & Eswayah, A. (2022) · Health Sciences Review · doi:10.1016/j.hsr.2021.100011 · Cited by 17
ExoU-induced redox imbalance and oxidative stress in airway epithelial cells during Pseudomonas aeruginosa pneumosepsis
da Cunha, L. G., Ferreira, M. F., Moraes, J. A., Reis, P. A., Castro-Faria-Neto, H. C., Barja‐Fidalgo, C., Plotkowski, M. C., & Saliba, A. M. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0418-x · Cited by 17
Limited Role of the Receptor for Advanced Glycation End Products during Streptococcus pneumoniae Bacteremia
Achouiti, A., de Vos, A. F., de Beer, R., Florquin, S., Veer, C. V. ′., & van der Poll, T. (2013) · Journal of Innate Immunity · doi:10.1159/000348739 · Cited by 17
EFFECTS OF Cl2MDP-ENCAPSULATING LIPOSOMES IN A MURINE MODEL OFPSEUDOMONAS AERUGINOSA-INDUCED SEPSIS
Fujimoto, J., Wiener-Kronish, J. P., Hashimoto, S., & Sawa, T. (2002) · Journal of Liposome Research · doi:10.1081/lpr-120014760 · Cited by 17
Self-citation
Clinical acute lung injury and acute respiratory distress syndrome
Matthay, M. A., Uchida, T., & Fang, X. (2002) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-002-0034-0 · Cited by 17
A therapeutic strategy against the shared virulence mechanism utilized by both Yersinia pestis and Pseudomonas aeruginosa
Sawa, T., & Wiener-Kronish, J. P. (2004) · Anesthesiology Clinics of North America · doi:10.1016/j.atc.2004.05.002 · Cited by 17
Self-citation

Authors: Kurahashi, K., Kajikawa, O., Sawa, T., Ohara, M., Gropper, M. A., Frank, D. W., Martin, T. R., & Wiener-Kronish, J. P.
Affiliations: University of California, San Francisco (US)
University of Washington (US)
Medical College of Wisconsin (US)
Corresponding author: Wiener-Kronish, Jeanine P.
ORCID: Kurahashi, Kiyoyasu
Sawa, Teiji
Gropper, Michael A.
Frank, Dara W.
Martin, Thomas R.
Wiener-Kronish, Jeanine P.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1999-09-15
Volume: 104
Issue: 6
Pages: 743-750
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci7124
PMC: PMC408437
OpenAlex: W2087967484
Cited by: 316
References: 36
Citations by year: 2026: 2 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 8 · 2020: 7 · 2019: 4 · 2018: 7 · 2017: 11 · 2016: 14 · 2015: 14 · 2014: 18 · 2013: 8 · 2012: 16
FWCI: 8.90
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL49810, HL-59239, R01HL059239, R01HL049810)
National Institute of General Medical Sciences (P01GM037696)
National Institute of Allergy and Infectious Diseases (AI31665)
Topics: Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: septic shock, Pseudomonas aeruginosa pneumonia, type III secretion system, alveolar epithelial injury, TNF-α, IL-10, bacteremia, systemic inflammatory response, rabbit model
MeSH terms: Animals, Cell Line, Humans, Male, Pseudomonas aeruginosa, Pseudomonas Infections, Rabbits, Recombinant Proteins, Shock, Septic, Tumor Necrosis Factor-alpha, Interleukin-10, Pneumonia, Bacterial

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks