The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
New developments in clinical aspects of lymphatic disease
Open accessAbstract
The lymphatic system is fundamentally important to cardiovascular disease, infection and immunity, cancer, and probably obesity--the four major challenges in healthcare in the 21st century. This Review will consider the manner in which new knowledge of lymphatic genes and molecular mechanisms has demonstrated that lymphatic dysfunction should no longer be considered a passive bystander in disease but rather an active player in many pathological processes and, therefore, a genuine target for future therapeutic developments. The specific roles of the lymphatic system in edema, genetic aspects of primary lymphedema, infection (cellulitis/erysipelas), Crohn's disease, obesity, cancer, and cancer-related lymphedema are highlighted.
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Cites
Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis
DiSipio, T., Rye, S., Newman, B., & Hayes, S. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70076-7 · Cited by 1,885
Microvascular fluid exchange and the revised Starling principle
Levick, J. R., & Michel, C. C. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq062 · Cited by 1,183
Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema
Karkkainen, M. J., Ferrell, R. E., Lawrence, E. C., Kimak, M. A., Levinson, K. L., McTigue, M. A., Alitalo, K., & Finegold, D. N. (2000) · Nature Genetics · doi:10.1038/75997 · Cited by 650
Fang, J., Dagenais, S. L., Erickson, R. P., Arlt, M. F., Glynn, M. W., Gorski, J. L., Seaver, L. H., & Glover, T. W. (2000) · The American Journal of Human Genetics · doi:10.1086/316915 · Cited by 611
Petrova, T. V., Karpanen, T., Norrmén, C., Mellor, R., Tamakoshi, T., Finegold, D., Ferrell, R., Kerjaschki, D., Mortimer, P., Ylä-Herttuala, S., et al. (2004) · Nature Medicine · doi:10.1038/nm1094 · Cited by 592
Self-citationLymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity
Harvey, N. L., Srinivasan, R. S., Dillard, M. E., Johnson, N. C., Witte, M. H., Boyd, K., Sleeman, M. W., & Oliver, G. (2005) · Nature Genetics · doi:10.1038/ng1642 · Cited by 580
Risk factors for erysipelas of the leg (cellulitis): case-control study
Dupuy, A., Benchikhi, H., Roujeau, J.-C., Bernard, P., Vaillant, L., Chosidow, O., Sassolas, B., Guillaume, J.-C., Grob, J.-J., & Bastuji-Garin, S. (1999) · BMJ · doi:10.1136/bmj.318.7198.1591 · Cited by 575
Lymphoedema: an underestimated health problem
Moffatt, C. J., Franks, P. J., Doherty, D. C., Williams, A. F., Badger, C., Jeffs, E., Bosanquet, N., & Mortimer, P. S. (2003) · QJM · doi:10.1093/qjmed/hcg126 · Cited by 557
Self-citationOstergaard, P., Simpson, M. A., Connell, F. C., Steward, C. G., Brice, G., Woollard, W. J., Dafou, D., Kilo, T., Smithson, S., Lunt, P., et al. (2011) · Nature Genetics · doi:10.1038/ng.923 · Cited by 506
Self-citationEstimating the Population Burden of Lymphedema
Rockson, S. G., & Rivera, K. K. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1413.014 · Cited by 450
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Cited by
From Sewer to Saviour—Targeting the Lymphatic System to Promote Drug Exposure and Activity
Trevaskis, N. L., Kaminskas, L. M., & Porter, C. J. H. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4608 · Cited by 654
Lymphatic Vessel Network Structure and Physiology
Breslin, J. W., Yang, Y., Scallan, J. P., Sweat, R. S., Adderley, S. P., & Murfee, W. L. (2018) · Comprehensive Physiology · doi:10.1002/cphy.c180015 · Cited by 341
Brain-to-cervical lymph node signaling after stroke.
Esposito, E., Ahn, B. J., Shi, J., Nakamura, Y., Park, J. H., Mandeville, E. T., Yu, Z., Chan, S. J., Desai, R., Hayakawa, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13324-w · Cited by 123
Diagnostic approach to lower limb edema
Gasparis, A. P., Kim, P. S., Dean, S. M., Khilnani, N. M., & Labropoulos, N. (2020) · Phlebology: The Journal of Venous Disease · doi:10.1177/0268355520938283 · Cited by 90
Reduced lymphatic reserve in heart failure with preserved ejection fraction
Rossitto, G., Mary, S., McAllister, C., Neves, K. B., Haddow, L., Rocchiccioli, J. P., Lang, N. N., Murphy, C. L., Touyz, R. M., Petrie, M. C., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.10.022 · Cited by 77
Metadata
- Authors
- Mortimer, P. S., & Rockson, S. G.
- Venue
- Journal of Clinical Investigation
- Published
- 2014-03-03
- Volume
- 124
- Issue
- 3
- Pages
- 915-921
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2136930833
- Cited by
- 357
- References
- 50
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mortimer, P. S., & Rockson, S. G. (2014). New developments in clinical aspects of lymphatic disease. Journal of Clinical Investigation. https://doi.org/10.1172/jci71608
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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