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Tsc2+/– mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
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“Here we report that mice with a heterozygous, inactivating mutation in the *Tsc2* gene (*Tsc2*+/− mice)[8](#R8) show deficits in learning and memory.”
From Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis (2008) · cites this paper as [8]
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“In the *Tsc2*+/− mouse model, the *Tsc2* gene is disrupted by insertion of a selection cassette in its second coding exon[8](#R8).”
From Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis (2008) · cites this paper as [8]
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“Because there is a close functional interaction between the Tsc1 and Tsc2 proteins, it is more likely that genetic background[8](#R8),[11](#R11) accounts for the differences in social behavior.”
From Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis (2008) · cites this paper as [8]
In the citing paper
“a result consistent with the idea that modifier genes in the genetic background influence the expressivity of tuberous sclerosis phenotypes[5](#R5),[8](#R8),[11](#R11).”
From Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis (2008) · cites this paper as [8]
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Cited by
Sorted by citations
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
Inoki, K., Li, Y., Zhu, T., Wu, J., & Guan, K.-L. (2002) · Nature Cell Biology · doi:10.1038/ncb839 · Cited by 3,083
Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
Ehninger, D., Han, S., Shilyansky, C., Zhou, Y., Li, W., Kwiatkowski, D. J., Ramesh, V., & Silva, A. J. (2008) · Nature Medicine · doi:10.1038/nm1788 · Cited by 882
Self-citationRegulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models
Schiaffino, S., & Mammucari, C. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-4 · Cited by 816
“TSC1 null Embryonic lethality [126] TSC2 null Embryonic lethality [ 127 ]”
BackgroundMutations causing syndromic autism define an axis of synaptic pathophysiology
Auerbach, B. D., Osterweil, E. K., & Bear, M. F. (2011) · Nature · doi:10.1038/nature10658 · Cited by 592
Metadata
- Authors
- Onda, H., Lueck, A., Marks, P. W., Warren, H. B., & Kwiatkowski, D. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1999-09-15
- Volume
- 104
- Issue
- 6
- Pages
- 687-695
- ISSN
- 0021-9738
- Cited by
- 349
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Tsc2+/– mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. https://app.cochat.ai/papers/10.1172/jci7319
- The paper
- Onda, H., Lueck, A., Marks, P. W., Warren, H. B., & Kwiatkowski, D. J. (1999). Tsc2+/– mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. Journal of Clinical Investigation. https://doi.org/10.1172/jci7319
