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VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain
Open accessAbstract
VEGF is a secreted mitogen associated with angiogenesis and is also a potent vascular permeability factor. The biological role of VEGF in the ischemic brain remains unknown. This study was undertaken to investigate whether VEGF enhances cerebral microvascular perfusion and increases blood-brain barrier (BBB) leakage in the ischemic brain. Using magnetic resonance imaging (MRI), three-dimensional laser-scanning confocal microscope, and functional neurological tests, we measured the effects of administrating recombinant human VEGF(165) (rhVEGF(165)) on angiogenesis, functional neurological outcome, and BBB leakage in a rat model of focal cerebral embolic ischemia. Late (48 hours) administration of rhVEGF(165) to the ischemic rats enhanced angiogenesis in the ischemic penumbra and significantly improved neurological recovery. However, early postischemic (1 hour) administration of rhVEGF(165) to ischemic rats significantly increased BBB leakage, hemorrhagic transformation, and ischemic lesions. Administration of rhVEGF(165) to ischemic rats did not change BBB leakage and cerebral plasma perfusion in the contralateral hemisphere. Our results indicate that VEGF can markedly enhance angiogenesis in the ischemic brain and reduce neurological deficits during stroke recovery and that inhibition of VEGF at the acute stage of stroke may reduce the BBB permeability and the risk of hemorrhagic transformation after focal cerebral ischemia.
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“As a pleiotropic growth factor, VEGF is responsible for multiple important physiological functions, particularly BBB permeability [44, 50, 51].”
From Chronic stress-induced depression requires the recruitment of peripheral Th17 cells into the brain (2022) · cites this paper as [50]
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“Similar findings about the importance of timing for administration of a neurorestorative therapy for stroke have been reported for VEGF94 and modulators of matrix metallo proteinases.95”
From Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation (2012) · cites this paper as [94]
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Cites
Le Bihan, D., Breton, E., Lallemand, D., Grenier, P., Cabanis, E., & Laval-Jeantet, M. (1986) · Radiology · doi:10.1148/radiology.161.2.3763909 · Cited by 3,912
Dvorak, H. F., Brown, L. F., Detmar, M. J., & Dvořàk, A. M. (1995) · Europe PMC (PubMed Central) · Cited by 3,100
FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE
Reese, T. S., & Karnovsky, M. J. (1967) · The Journal of Cell Biology · doi:10.1083/jcb.34.1.207 · Cited by 2,629
Magnetic resonance imaging of perfusion using spin inversion of arterial water.
Williams, D. S., Detre, J. A., Leigh, J. S., & Koretsky, A. P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.212 · Cited by 1,553
Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1
Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T. T., Yancopoulos, G. D., & McDonald, D. M. (1999) · Science · doi:10.1126/science.286.5449.2511 · Cited by 1,350
Angiopoietin-1 protects the adult vasculature against plasma leakage
Thurston, G., Rudge, J. S., Ioffe, E., Zhou, H., Ross, L. H., Croll, S. D., Glazer, N. L., Holash, J. A., McDonald, D. M., & Yancopoulos, G. D. (2000) · Nature Medicine · doi:10.1038/74725 · Cited by 1,314
Peptide Growth Factors and Their Receptors
Arai, K., Battey, J. F., Sporn, M. B., & Roberts, A. B. (1991) · Medical Entomology and Zoology · Cited by 1,225
Breier, G., Albrecht, U., Sterrer, S., & Risau, W. (1992) · Development · doi:10.1242/dev.114.2.521 · Cited by 1,087
Takeshita, S., Zheng, L., Brogi, E., Kearney, M., Pu, L. L. Q., Bunting, S., Ferrara, N., Symes, J. F., & Isner, J. M. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117018 · Cited by 1,034
A functional MRI study of subjects recovered from hemiparetic stroke
Cramer, S. C., Nelles, G., Benson, R. R., Kaplan, J. D., Parker, R. A., Kwong, K. K., Kennedy, D. N., Finklestein, S. P., & Rosen, B. R. (1997) · Stroke · doi:10.1161/01.str.28.12.2518 · Cited by 1,019
Role of angiogenesis in patients with cerebral ischemic stroke.
Krupiński, J., Kałuza, J., Kumar, P., Kumar, S., & Wang, J. M. (1994) · Stroke · doi:10.1161/01.str.25.9.1794 · Cited by 870
A requirement for neuropilin-1 in embryonic vessel formation
Kawasaki, T., Kitsukawa, T., Bekku, Y., Matsuda, Y., Sanbo, M., Yagi, T., & Fujisawa, H. (1999) · Development · doi:10.1242/dev.126.21.4895 · Cited by 844
Gale, N. W., & Yancopoulos, G. D. (1999) · Genes & Development · doi:10.1101/gad.13.9.1055 · Cited by 794
Brodie, S. E. (1996) · Survey of Ophthalmology · doi:10.1016/s0039-6257(96)80075-0 · Cited by 770
Sondell, M., Lundborg, G., & Kanje, M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05731.1999 · Cited by 750
Willer, C., Ramsay, S. C., Wise, R. J. S., Friston, K. J., & Frackowiak, R. S. J. (1993) · Annals of Neurology · doi:10.1002/ana.410330208 · Cited by 740
Hamm, R. J., PIKE, B. R., O’Dell, D. M., Lyeth, B. G., & Jenkins, L. W. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.187 · Cited by 643
Banai, S., Jaklitsch, M. T., Shou, M., Lazarous, D. F., Scheinowitz, M., Biro, S., Epstein, S. E., & Unger, E. F. (1994) · Circulation · doi:10.1161/01.cir.89.5.2183 · Cited by 590
Belayev, L., Busto, R., Zhao, W., & Ginsberg, M. D. (1996) · Brain Research · doi:10.1016/s0006-8993(96)00815-3 · Cited by 505
Iadecola, C. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90156-g · Cited by 481
van Bruggen, N., Thibodeaux, H., Palmer, J. T., Lee, W. P., Fu, L., Cairns, B., Tumas, D. B., Gerlai, R. T., Williams, S., Campagne, M. V. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8218 · Cited by 457
Self-citationThe role of vascular endothelial growth factor in pathological angiogenesis
Ferrara, N. (1995) · Breast Cancer Research and Treatment · doi:10.1007/bf00666035 · Cited by 413
Stroemer, R. P., Kent, T. A., & Hulsebosch, C. E. (1998) · Stroke · doi:10.1161/01.str.29.11.2381 · Cited by 349
A rat model of focal embolic cerebral ischemia
Zhang, R. L., Chopp, M., Zhang, Z. G., Jiang, Q., & Ewing, J. R. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00580-5 · Cited by 332
Self-citationSchallert, T., Upchurch, M., Lobaugh, N. J., Farrar, S. B., Spirduso, W. W., Gilliam, P. E., Vaughn, D. M., & Wilcox, R. E. (1982) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(82)90452-x · Cited by 326
Hayashi, T., Abe, K., Suzuki, H., & Itoyama, Y. (1997) · Stroke · doi:10.1161/01.str.28.10.2039 · Cited by 311
Hayashi, T., Abe, K., & Itoyama, Y. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199808000-00009 · Cited by 305
Gotoh, O., Asano, T., Koide, T., & Takakura, K. (1985) · Stroke · doi:10.1161/01.str.16.1.101 · Cited by 303
MORPHOMETRIC DATA ON THE ENDOTHELIUM OF BLOOD CAPILLARIES
Simionescu, M., Simionescu, N., & Palade, G. E. (1974) · The Journal of Cell Biology · doi:10.1083/jcb.60.1.128 · Cited by 296
Effect of Intracoronary Recombinant Human Vascular Endothelial Growth Factor on Myocardial Perfusion
Hendel, R. C., Henry, T. D., Rocha‐Singh, K. J., Isner, J. M., Kereiakes, D. J., Giordano, F. J., Simons, M., & Bonow, R. O. (2000) · Circulation · doi:10.1161/01.cir.101.2.118 · Cited by 295
Feng, D., Nagy, J. A., Hipp, J. A., Dvorak, H. F., & Dvořàk, A. M. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.5.1981 · Cited by 278
Kovács, Z., Ikezaki, K., Samoto, K., Inamura, T., & Fukui, M. (1996) · Stroke · doi:10.1161/01.str.27.10.1865 · Cited by 277
Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy
Schratzberger, P., Schratzberger, G., Silver, M., Curry, C., Kearney, M., Magner, M., Alroy, J., Adelman, L. S., Weinberg, D. H., Ropper, A. H., et al. (2000) · Nature Medicine · doi:10.1038/74664 · Cited by 247
Effects of Vascular Endothelial Growth Factor on Hemodynamics and Cardiac Performance
Yang, R., Thomas, G. R., Bunting, S., Ko, A., Ferrara, N., Keyt, B. A., Ross, J., & Jin, H. (1996) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199606000-00011 · Cited by 244
VEGF induces NO-dependent hyperpermeability in coronary venules
Wu, H. M., Huang, Q., Yuan, Y., & Granger, H. J. (1996) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1996.271.6.h2735 · Cited by 243
Mayhan, W. G. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.276.5.c1148 · Cited by 235
Lennmyr, F., Ata, K. A., Funa, K., Olsson, Y., & Terént, A. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199809000-00009 · Cited by 233
Dellian, M., Witwer, B. P., Salehi, H. A., Yuan, F., & Jain, R. K. (1996) · Europe PMC (PubMed Central) · Cited by 232
Cheng, S., Nagane, M., Huang, H., & Cavenee, W. K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.12081 · Cited by 224
Rosenstein, J. M., Mani, N., Silverman, W. F., & Krum, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7086 · Cited by 214
Ingber, D. E., Madri, J. A., & Folkman, J. (1986) · Endocrinology · doi:10.1210/endo-119-4-1768 · Cited by 213
Bauters, C., Asahara, T., Zheng, L. P., Takeshita, S., Bunting, S., Ferrara, N., Symes, J. F., & Isner, J. M. (1995) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(95)70272-5 · Cited by 203
Matesic, D. F., & Lin, R. C. S. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63031012.x · Cited by 176
Brain edema and cerebrovascular permeability during cerebral ischemia in rats.
Hatashita, S., & Hoff, J. T. (1990) · Stroke · doi:10.1161/01.str.21.4.582 · Cited by 175
Role of vascular endothelial cell growth factor in Ovarian Hyperstimulation Syndrome.
Levin, E. R., Rosen, G. F., Cassidenti, D. L., Yee, B., Meldrum, D. R., Wisot, A. L., & Pedram, A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4814 · Cited by 172
Hemorrhagic transformation after cerebral ischemia: mechanisms and incidence.
Lyden, P. D., & Zivin, J. A. (1993) · PubMed · Cited by 162
Molecular analysis of blood vessel formation and disease
Carmeliet, P., & Collen, D. (1997) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1997.273.5.h2091 · Cited by 161
Development and differentiation of endothelium
Risau, W. (1998) · Kidney International · doi:10.1046/j.1523-1755.1998.06701.x · Cited by 152
Zhang, L., Chen, J., Li, Y., Zhang, Z. G., & Chopp, M. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00268-9 · Cited by 117
Self-citationWang, W., Merrill, M. J., & BORCHARDT, R. T. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.6.c1973 · Cited by 113
HONG, Q., Nagy, J. A., Senger, D. R., Dvorak, H. F., & Dvořàk, A. M. (1995) · Journal of Histochemistry & Cytochemistry · doi:10.1177/43.4.7534783 · Cited by 113
Knight, R. A., Barker, P. B., Fagan, S. C., Li, Y., Jacobs, M. A., & Welch, K. M. A. (1998) · Stroke · doi:10.1161/01.str.29.1.144 · Cited by 109
Kuroiwa, T., Shibutani, M., & Okeda, R. (1988) · Acta Neuropathologica · doi:10.1007/bf00687681 · Cited by 98
Jiang, Q., Zhang, R. L., Zhang, Z. G., Ewing, J. R., Divine, G., & Chopp, M. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199807000-00007 · Cited by 95
Self-citationIncreased therapeutic efficacy with rt-PA and anti-CD18 antibody treatment of stroke in the rat
Zhang, R. L., Zhang, Z. G., & Chopp, M. (1999) · Neurology · doi:10.1212/wnl.52.2.273 · Cited by 94
Self-citationJiang, Q., Chopp, M., Zhang, Z. G., Knight, R. A., Jacobs, M. A., Windham, J. P., Peck, D. J., Ewing, J. R., & Welch, K. M. A. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(96)00286-9 · Cited by 93
Self-citationBlood flow through cerebral collateral vessels one month after middle cerebral artery occlusion.
Coyle, P. V., & Heistad, D. D. (1987) · Stroke · doi:10.1161/01.str.18.2.407 · Cited by 86
Prognostic value of blood vessel density in ischaemic stroke
Krupiński, J., Kałuza, J., Kumar, P., Wang, M., & Kumar, S. (1993) · The Lancet · doi:10.1016/0140-6736(93)91734-4 · Cited by 83
Vascular endothelial growth factor. 20th-century mechanisms, 21st-century therapies.
Aiello, L. P. (1997) · PubMed · Cited by 79
The role of polypeptide growth factors in recovery from stroke.
Kawamata, T., Speliotes, E. K., & Finklestein, S. P. (1997) · PubMed · Cited by 71
Cancilla, P. A., Frommes, S. P., Le, K., & DeBault, L. E. (1979) · PubMed · Cited by 62
Zhang, Z., Davies, K., Prostak, J., Fenstermacher, J. D., & Chopp, M. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199901000-00008 · Cited by 52
Self-citationLiu, H. M., & Chen, H. H. (1994) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199403000-00002 · Cited by 51
Imaging System for Three-Dimensional Mapping of Cerebrocortical Capillary Networks in Vivo
Hudetz, A. G., Greene, A. S., Fehér, G., Knuese, D. E., & Cowley, A. W. (1993) · Microvascular Research · doi:10.1006/mvre.1993.1054 · Cited by 50
Parenchymal microvascular systems and cerebral atrophy in spontaneously hypertensive rats
Gesztelyi, G., Finnegan, W., Demaro, J. A., Wang, J., Chen, J.-L., & Fenstermacher, J. D. (1993) · Brain Research · doi:10.1016/0006-8993(93)90510-t · Cited by 50
Wu, D., & Mori, N. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.5.c1765 · Cited by 50
Yang, R., Bunting, S., Ko, A., Keyt, B. A., Modi, N. B., Zioncheck, T. F., Ferrara, N., & Jin, H. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37199-x · Cited by 43
The microvascular system in ischemic cortical lesions
Sbarbati, A., Pietra, C., Baldassarri, A. M., Guerrini, U., Ziviani, L., Reggiani, A. M., Boicelli, A. C., & Osculati, F. (1996) · Acta Neuropathologica · doi:10.1007/s004010050489 · Cited by 42
Combined effects of magnetization transfer and gadolinium in cranial MR imaging and MR angiography.
Mathews, V. P., Elster, A. D., King, J. C., Ulmer, J. L., Hamilton, C. A., & Strottmann, J. M. (1995) · American Journal of Roentgenology · doi:10.2214/ajr.164.1.7998532 · Cited by 40
Role of blood-brain barrier permeability in focal ischemic brain edema.
Hatashita, S., & Hoff, J. T. (1990) · PubMed · Cited by 33
Miyoshi, Y., Date, I., & Ohmoto, T. (1995) · Experimental Neurology · doi:10.1016/0014-4886(95)90009-8 · Cited by 32
Zhao, L., Zhang, M. M., & Ng, K. (1998) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199807000-00001 · Cited by 28
Analysis of the evolution of focal cerebral ischemia in the rat using the eigenimage filter
Peck, D. J., Spickler, E. M., Knight, R. A., Hearshen, D., & Windham, J. P. (1992) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910260207 · Cited by 25
Criscuolo, G. R., Mj, M., & Eh, O. (1990) · PubMed · Cited by 22
Pons, T. P. (1998) · Nature Medicine · doi:10.1038/nm0598-561 · Cited by 7
Research works printed but not linked: 8
- Carmeliet, 1997, Am J Physiol, 273, H2091
- Aiello, 1997, Invest Ophthalmol Vis Sci, 38, 1647
- Dvorak, 1995, Am J Pathol, 146, 1029
- Hatashita, 1990, Adv Neurol, 52, 327
- Lyden, 1993, Cerebrovasc Brain Metab Rev, 5, 1
- Dellian, 1996, Am J Pathol, 149, 59
- Cancilla, 1979, Lab Invest, 40, 74
- Criscuolo, 1990, Adv Neurol, 52, 469
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Lo, E. H., Dalkara, T., & Moskowitz, M. A. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1106 · Cited by 1,808
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
Jin, K., Zhu, Y., Sun, Y., Mao, X. O., Xie, L., & Greenberg, D. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182296499 · Cited by 1,507
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317977 · Cited by 1,189
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
Sun, Y., Jin, K., Xie, L., Childs, J., Mao, X. O., Logvinova, A. V., & Greenberg, D. A. (2003) · Journal of Clinical Investigation · doi:10.1172/jci17977 · Cited by 1,201
“One major determinant of the effect of VEGF on the ischemic brain (and a likely source of variability in the studies mentioned above) is the prominence of VEGF-induced edema, which is related to VEGF’s ability to enhance vascular permeability (13, 34).”
Influential
Metadata
- Authors
- Zhang, Z. G., Zhang, L., Jiang, Q., Zhang, R., Davies, K., Powers, C., Bruggen, N. V., & Chopp, M.
- Affiliations
- Henry Ford Health (US)
- Henry Ford Hospital (US)
- Genentech (US)
- Oakland University (US)
- Corresponding author
- Chopp, Michael
- Venue
- Journal of Clinical Investigation
- Published
- 2000-10-01
- Volume
- 106
- Issue
- 7
- Pages
- 829-838
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC517814
- OpenAlex
- W2084498863
- Cited by
- 1,296
- References
- 75
- Citations by year
- 2026: 32 · 2025: 49 · 2024: 53 · 2023: 52 · 2022: 64 · 2021: 73 · 2020: 58 · 2019: 42 · 2018: 59 · 2017: 59 · 2016: 61 · 2015: 49 · 2014: 70 · 2013: 70 · 2012: 64
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns033627-08)
- National Institute of Neurological Disorders and Stroke (P01NS23393, R01NS-33627, P01NS023393)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Keywords
- vascular endothelial growth factor, angiogenesis, blood-brain barrier disruption, cerebral ischemia, hemorrhagic transformation, ischemic penumbra, neurological recovery, VEGF inhibition, stroke
- MeSH terms
- Animals, Blood-Brain Barrier, Brain Ischemia, Image Processing, Computer-Assisted, Lymphokines, Magnetic Resonance Imaging, Male, Microcirculation, Neovascularization, Pathologic, Regional Blood Flow, Endothelial Growth Factors, Treatment Outcome, Rats, Wistar, Stroke, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Rats
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