The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
IL-10–producing T cells suppress immune responses in anergic tuberculosis patients
Open accessAbstract
The lethality of Mycobacterium tuberculosis remains the highest among infectious organisms and is linked to inadequate immune response of the host. Containment and cure of tuberculosis requires an effective cell-mediated immune response, and the absence, during active tuberculosis infection, of delayed-type hypersensitivity (DTH) responses to mycobacterial antigens, defined as anergy, is associated with poor clinical outcome. To investigate the biochemical events associated with this anergy, we screened 206 patients with pulmonary tuberculosis and identified anergic patients by their lack of dermal reactivity to tuberculin purified protein derivative (PPD). In vitro stimulation of T cells with PPD induced production of IL-10, IFN-gamma, and proliferation in PPD(+) patients, whereas cells from anergic patients produced IL-10 but not IFN-gamma and failed to proliferate in response to this treatment. Moreover, in anergic patients IL-10-producing T cells were constitutively present, and T-cell receptor-mediated (TCR-mediated) stimulation resulted in defective phosphorylation of TCRzeta and defective activation of ZAP-70 and MAPK. These results show that T-cell anergy can be induced by antigen in vivo in the intact human host and provide new insights into mechanisms by which M. tuberculosis escapes immune surveillance.
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Cited by
Dardalhon, V., Awasthi, A., Kwon, H., Galileos, G., Gao, W., Sobel, R. A., Mitsdoerffer, M., Strom, T. B., Elyaman, W., Ho, I.-C., et al. (2008) · Nature Immunology · doi:10.1038/ni.1677 · Cited by 1,122
Mechanisms of allergen-specific immunotherapy
Akdis, C. A., & Akdis, M. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.11.030 · Cited by 803
Regulatory T cells and infection: a dangerous necessity
Belkaid, Y. (2007) · Nature Reviews Immunology · doi:10.1038/nri2189 · Cited by 745
Regulatory T Cells Are Expanded in Blood and Disease Sites in Patients with Tuberculosis
Guyot-Revol, V., Innes, J. A., Hackforth, S., Hinks, T., & Lalvani, A. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200508-1294oc · Cited by 444
Akdis, M., Blaser, K., & Akdis, C. A. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.09.004 · Cited by 351
Metadata
- Authors
- Boussiotis, V. A., Tsai, E. Y., Yunis, E. J., Thim, S., Delgado, J. C., Dascher, C. C., Berezovskaya, A., Rousset, D., Reynes, J.-M., & Goldfeld, A. E.
- Venue
- Journal of Clinical Investigation
- Published
- 2000-05-01
- Volume
- 105
- Issue
- 9
- Pages
- 1317-1325
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2082734149
- Cited by
- 398
- References
- 53
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Boussiotis, V. A., Tsai, E. Y., Yunis, E. J., Thim, S., Delgado, J. C., Dascher, C. C., Berezovskaya, A., Rousset, D., Reynes, J.-M., & Goldfeld, A. E. (2000). IL-10–producing T cells suppress immune responses in anergic tuberculosis patients. Journal of Clinical Investigation. https://doi.org/10.1172/jci9918
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