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Carbamazepine in manic-depressive illness: a new treatment
Abstract
The authors evaluated carbamazepine (Tegretol), a drug of choice for treatment of temporal lobe epilepsy, in a double-blind placebo-controlled trial in patients with manic-depressive illness. Seven of 9 manic patients had a partial to marked response; several also showed relapses when placebo was substituted and improvement when carbamazepine was reinstituted. Five of 13 depressed patients showed significant improvement in depression ratings; 3 additional patients experienced partial relapse when placebo was substituted. Carbamazepine might also have prophylactic as well as acute efficacy in patients with both phases of manic-depressive illness, including some patients who do not respond to lithium. Therapeutic effects were achieved with 600-1600 mg/day at blood levels of 8-12 microgram/ml with relatively few side effects. Carbamazepine may prove to be a useful additional treatment for affective illness.
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Citations
Cites
Kindling as a Model for Alcohol Withdrawal Syndromes
Ballenger, J. C., & Post, R. M. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.1.1 · Cited by 463
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Swerdlow, N. R., & Koob, G. F. (1987) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00047488 · Cited by 674
Practice Guideline for the Treatment of Patients With Bipolar Disorder (Revision)
Hirschfeld, R. M. A., Bowden, C. L., Gitlin, M. J., Keck, P. E., Perlis, R. H., Suppes, T., Thase, M. E., & Wagner, K. D. (2003) · Focus · doi:10.1176/foc.1.1.64 · Cited by 585
Nanoencapsulation of phase change materials for advanced thermal energy storage systems
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Vagus nerve stimulation: a new tool for brain research and therapy
George, M. S., Sackeim, H. A., Rush, A. J., Marangell, L. B., Nahas, Z., Husain, M. M., Lisanby, S., Burt, T., Goldman, J., & Ballenger, J. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00308-x · Cited by 461
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Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1980-07-01
- Volume
- 137
- Issue
- 7
- Pages
- 782-790
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1890987751
- Cited by
- 484
- References
- 1
- FWCI
- 17.09
- Type
- journal article
- Language
- en
- Open access
- closed
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
