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Aggression, suicide, and serotonin: relationships to CSF amine metabolites
Abstract
In an earlier, separate study, the authors found that human aggression and suicide (a specific aggression-related behavior) were associated with lower levels of CSF 5-hydroxyindoleacetic acid (5-HIAA), a serotonin metabolite. That study focused on subjects with personality disorders without affective illness. In the present study they examine the life history of aggression and history of suicidal behavior in 12 subjects with borderline personality disorders without major affective disorder. Histories of aggressive behaviors and of suicide attempts were significantly associated with each other, and each was significantly associated with lower 5-HIAA levels. Altered serotonin metabolism may be a highly significant contributing factor to these behaviors in whatever diagnostic group they occur.
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Citations
Cites
"Serotonin Depression"—A Biochemical Subgroup Within the Affective Disorders?
Åsberg, M., Thorén, P., Traskman, L., Bertilsson, L., & Ringberger, V. (1976) · Science · doi:10.1126/science.1246632 · Cited by 682
Cited by
Allostasis and Allostatic Load Implications for Neuropsychopharmacology
McEwen, B. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00129-3 · Cited by 1,833
Linnoila, M., Virkkunen, M., Scheinin, M., Nuutila, A., Rimon, R., & Goodwin, F. K. (1983) · Life Sciences · doi:10.1016/0024-3205(83)90344-2 · Cited by 1,308
Neurobiology of Aggression and Violence
Siever, L. J. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07111774 · Cited by 984
McEwen, B. S., Biron, C. A., Brunson, K. W., Bulloch, K., Chambers, W. H., Dhabhar, F. S., Goldfarb, R. H., Kitson, R. P., Miller, A. H., Spencer, R. L., et al. (1997) · Brain Research Reviews · doi:10.1016/s0165-0173(96)00012-4 · Cited by 837
A psychobiological perspective on the personality disorders
(1991) · American Journal of Psychiatry · doi:10.1176/ajp.148.12.1647 · Cited by 659
Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1982-06-01
- Volume
- 139
- Issue
- 6
- Pages
- 741-746
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1784545427
- Cited by
- 908
- References
- 1
- FWCI
- 27.32
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.