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Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital
Abstract
Neuroleptic malignant syndrome, a dangerous but little-known complication of antipsychotic drugs, is often assumed to be rare. To assess the frequency of the syndrome in a large psychiatric hospital, the authors first reviewed the literature and developed operational diagnostic criteria. Using these criteria to survey nearly 500 neuroleptic-treated patients admitted during a 1-year period, they found that seven (1.4%) had experienced definite or probable neuroleptic malignant syndrome. In several cases, including one fatal case, the diagnosis of neuroleptic malignant syndrome was not immediately considered. The authors conclude that neuroleptic malignant syndrome may be more common than previously thought and may be underdiagnosed.
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Cited by
Neuroleptic Malignant Syndrome
Strawn, J. R., Keck, P. E., & Caroff, S. N. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.6.870 · Cited by 579
Catatonia: A Clinician's Guide to Diagnosis and Treatment
Fink, M., & Taylor, M. A. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511543777 · Cited by 269
Neuroleptic Malignant Syndrome: A Review from a Clinically Oriented Perspective
Tse, L., Barr, A., Scarapicchia, V., & Vila-Rodriguez, F. (2015) · Current Neuropharmacology · doi:10.2174/1570159x13999150424113345 · Cited by 179
Antipsychotic Medication and People with Intellectual Disabilities: Their Knowledge and Experiences
Crossley, R., & Withers, P. (2009) · Journal of Applied Research in Intellectual Disabilities · doi:10.1111/j.1468-3148.2008.00454.x · Cited by 32
Psychotropic discontinuation leading to an NMS‐like condition
Kurien, R., & Vattakatuchery, J. J. (2013) · Progress in Neurology and Psychiatry · doi:10.1002/pnp.297 · Cited by 6
Metadata
- Venue
- American Journal of Psychiatry
- Published
- 1986-10-01
- Volume
- 143
- Issue
- 10
- Pages
- 1227-1233
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2339505404
- Cited by
- 302
- References
- 0
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Frequency and presentation of neuroleptic malignant syndrome in a large psychiatric hospital. (1986). American Journal of Psychiatry. https://doi.org/10.1176/ajp.143.10.1227
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
