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Cited by 30Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorRestless Legs Syndrome Research

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Randomized, double-blind, crossover, placebo-controlled comparison of propranolol and betaxolol in the treatment of neuroleptic-induced akathisia

J P Dumon, J Catteau, F. Lanvin, B Dupuis·1992·American Journal of Psychiatry
DOI 10.1176/ajp.149.5.647
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Abstract

Objective Beta-blocking agents, particularly propranolol, are considered effective in the treatment of neuroleptic-induced akathisia, but considerable controversy exists about the involved receptor subtype(s). The authors conducted a randomized, controlled trial comparing the effects of propranolol and betaxolol to determine whether central beta 1-adrenoceptor blockade is sufficient to correct neuroleptic-induced akathisia. Method The subjects were 19 patients whose neuroleptic-induced akathisia responded to 20 mg/day of propranolol and subsequently reemerged during a placebo washout period. They were randomly assigned to propranolol (20 or 40 mg/day) or betaxolol (10 or 20 mg/day) and, after another placebo period, were switched to the second beta blocker. Results There was no significant difference in the antiakathisia effects of propranolol and betaxolol. Conclusions The lack of difference between propranolol and betaxolol suggests that beta 1-adrenoceptor blockade is sufficient to improve neuroleptic-induced akathisia. The results of this explanatory study need therapeutic confirmation.

Overview

Integrity signals

Registry

Crossref · 10.1176/ajp.149.5.647

Cites

9 of 9 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

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Citations

Cites

Show all 9 references

Research works printed but not linked: 4

  1. Chouinard G, 1979, J Clin Psychiatry, 40, 147
  2. 1983, Betaxolol and Other 1-Adnenoceptor Antagonists
  3. Boudot JP, 1979, Br J Phanmacol, 66, 445P
  4. Emonine U, Delavier-Klutchko C

Cited by

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Related

Metadata

Authors
Dumon, J. P., Catteau, J., Lanvin, F., & Dupuis, B.
Affiliations
Université de Lille (FR)
Venue
American Journal of Psychiatry
Publisher
American Psychiatric Association Publishing
Published
1992-05-01
Volume
149
Issue
5
Pages
647-650
ISSN
  • 0002-953X (ISSN-L)
  • 1535-7228
DOI
10.1176/ajp.149.5.647
OpenAlex
W2412737633
Cited by
30
References
9
Citations by year
2024: 2 · 2023: 1 · 2020: 1 · 2018: 3 · 2016: 1 · 2014: 1
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Clinical Neurology › Restless Legs Syndrome Research
Keywords
neuroleptic-induced akathisia, propranolol, betaxolol, beta-blockers, antipsychotic adverse effects, drug-induced movement disorders, beta-blocker comparison
MeSH terms
Adult, Double-Blind Method, Humans, Middle Aged, Placebos, Propranolol, Psychomotor Agitation, Antipsychotic Agents, Betaxolol, Akathisia, Drug-Induced

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Data sources

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.