The DOI matches its Crossref record; 26 of the 27 references it cites were found in a registry or an index.
Efficacy and Tolerability of Carbamazepine for Agitation and Aggression in Dementia
Abstract
Objective The efficacy, safety, and tolerability of carbamazepine in the treatment of agitation and aggression associated with dementia were assessed. Method In a 6-week, randomized, multisite, parallel-group study of 51 nursing home patients with agitation and dementia, individualized doses of carbamazepine were compared with placebo. Except for a physician monitor and a pharmacist, all participants were blind to treatment. The primary outcome measures were the Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression (CGI) global improvement rating. Secondary measures included measures of behavior, aggression, cognition, functional status, staff time, safety, and tolerability. Intent-to-treat analysis was performed. Results The modal carbamazepine dose at 6 weeks was 300 mg/day, and a mean serum level of 5.3 micrograms/ml was achieved. The study was terminated after a planned interim analysis showed that carbamazepine provided more benefit than did placebo. Over 6 weeks the mean total BPRS score decreased 7.7 points for the carbamazepine group and 0.9 for the placebo group, and the weekly scores showed a gradual divergence between the two groups. CGI ratings showed global improvement in 77% of the patients taking carbamazepine and 21% of those taking placebo. Secondary analyses confirmed that the positive changes were due to decreased agitation and aggression. The drug was generally well tolerated, and no change in cognition or functional status occurred. The per…
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“Two small trials of carbamazepine (n=51 and n=21) of less than six weeks’ duration showed some benefit for agitation and global clinical outcomes.143 144”
From Assessment and management of behavioral and psychological symptoms of dementia (2015) · cites this paper as [143]
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&NA; (2002) · Drugs & Therapy Perspectives · doi:10.2165/00042310-200218030-00006
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Chapter 4. The Psychiatric Interview of Older Adults
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Chapter 22. Individual and Group Psychotherapy
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Chapter 2. Physiological and Clinical Considerations of Geriatric Patient Care
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Chapter 3. Genomics in Geriatric Psychiatry
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Chapter 26. Ethics in Geriatric Mental Health
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Chapter 21. Electroconvulsive Therapy and Other Forms of Brain Stimulation
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Chapter 23. Working With Families of Older Adults
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Chapter 6. Neuropsychological Assessment of Late-Life Cognitive Disorders
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Chapter 1. Epidemiology of Psychiatric Disorders in Later Life
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Chapter 24. Clinical Psychiatry in the Nursing Home
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Chapter 25. Use of Technology in Geriatric Psychiatry
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Chapter 9. Depressive Disorders
Andrews, P., & Taylor, W. D. (2022) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375196.ds09
Chapter 13. Somatic Symptom and Related Disorders
Agronin, M. (2022) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375196.ds13
Smoski, M. J., Schuette, S., & Thompson, L. W. (2022) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375196.ds15
Chapter 19. Agitation in Older Adults
Young, J. J., & Tampi, R. R. (2022) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375196.ds19
Chapter 16. Sleep and Circadian Rhythm Sleep-Wake Disorders
Rumble, M. E., & Plante, D. T. (2022) · American Psychiatric Association Publishing eBooks · doi:10.1176/appi.books.9781615375196.ds16
Chapter 10. Bipolar and Related Disorders
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Chapter 17. Substance-Related and Addictive Disorders
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Assessment and Management of Violent Behavior
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Neuropsychiatric Symptoms of Major or Mild Neurocognitive Disorders
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Medikamentöse Therapie von BPSD
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Depression and Alzheimer's Disease: Loss of Control and Communication
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Chapter 61. Treatment During Late Life
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Metadata
- Authors
- Tariot, P. N., Erb, R., Podgorski, C. A., Cox, C., Patel, S., Jakimovich, L., & Irvine, C.
- Affiliations
- University of Rochester Medicine (US)
- Venue
- American Journal of Psychiatry
- Published
- 1998-01-01
- Volume
- 155
- Issue
- 1
- Pages
- 54-61
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2140320787
- Semantic Scholar
- c3da70c064f129607116262314bf832944063d1a
- Cited by
- 422
- References
- 27
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 8 · 2023: 3 · 2022: 38 · 2021: 10 · 2020: 8 · 2019: 12 · 2018: 14 · 2017: 14 · 2016: 8 · 2015: 8 · 2014: 12 · 2013: 10 · 2012: 12
- FWCI
- 13.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 08665, AG-10463, P60AG010463, P30AG008665)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Medicine › Geriatrics and Gerontology › Geriatric Care and Nursing Homes
- Keywords
- carbamazepine, dementia, agitation, aggression, nursing home residents, antipsychotic efficacy, drug tolerability, safety, Brief Psychiatric Rating Scale, Clinical Global Impression Scale, staff time, individualized dosing
- MeSH terms
- Aged, Aged, 80 and over, Aggression, Alzheimer Disease, Carbamazepine, Dementia, Drug Administration Schedule, Female, Humans, Male, Nursing Homes, Placebos, Psychiatric Status Rating Scales, Psychomotor Agitation, Dementia, Vascular, Treatment Outcome
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