Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness

Mayberg, Helen S.; Liotti, Mario; Brannan, Stephen K.; McGinnis, Scott; Mahurin, Roderick K.; Jerabek, Paul A.; Silva, J. Arturo; Tekell, Janet L.; Martin, Charles C.; Lancaster, Jack L.; Fox, Peter T.

doi:10.1176/ajp.156.5.675

Reciprocal Limbic-Cortical Function and Negative Mood: Converging PET Findings in Depression and Normal Sadness

OBJECTIVE Theories of human behavior from Plato to Freud have repeatedly emphasized links between emotion and reason, a relationship now commonly attributed to pathways connecting phylogenetically "old" and "new" brain regions. Expanding on this theory, this study examined functional interactions…