Alterations in the Functional Anatomy of Working Memory in Adult Attention Deficit Hyperactivity Disorder
Abstract
OBJECTIVE: The authors used a functional neuroimaging study with a working memory probe to investigate the pathophysiology of attention deficit hyperactivity disorder (ADHD). Their goal was to compare regional cerebral blood flow (rCBF) changes related to working memory in adults with and without ADHD. METHOD: Using [(15)O]H(2)O positron emission tomography (PET) studies, the authors compared the sites of neural activation related to working memory in six adult men diagnosed with ADHD and six healthy men without ADHD who were matched in age and general intelligence. RESULTS: Task-related changes in rCBF in the men without ADHD were more prominent in the frontal and temporal regions, but rCBF changes in men with ADHD were more widespread and primarily located in the occipital regions. CONCLUSIONS: These data suggest the use of compensatory mental and neural strategies by subjects with ADHD in response to a disrupted ability to inhibit attention to nonrelevant stimuli and the use of internalized speech to guide behavior.
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Neuroimaging studies show abnormal prefrontal and parietal cortex functioning in children with ADHD during working memory tasks.
“Neuroimaging studies reveal abnormal PFC and parietal cortex functioning in children with ADHD during WM tasks [5-9, 39, 40].”
From Will Working Memory Training Generalize to Improve Off-Task Behavior in Children with Attention-Deficit/Hyperactivity Disorder? (2012) · cites this paper as [7]
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References 8 · Cited by 276
- Authors
- Schweitzer, J. B., Faber, T. L., Grafton, S. T., Tune, L. E., Hoffman, J. M., & Kilts, C. D.
- Affiliations
- Emory University (US)
- Venue
- American Journal of Psychiatry
- Published
- 2000-02-01
- Volume
- 157
- Issue
- 2
- Pages
- 278-280
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W1964800038
- Cited by
- 276
- References
- 8
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 6 · 2022: 3 · 2021: 9 · 2020: 5 · 2019: 2 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 10 · 2014: 10 · 2013: 13 · 2012: 14
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r03mh055550-01)
- National Institute of Mental Health (MH-01053, MH-55550, K08MH001053)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- attention deficit hyperactivity disorder, working memory, regional cerebral blood flow, adult ADHD, neural compensation, attentional inhibition, pathophysiology
- MeSH terms
- Adult, Attention, Attention Deficit Disorder with Hyperactivity, Auditory Perception, Cerebral Cortex, Frontal Lobe, Humans, Imagination, Male, Memory, Oxygen Radioisotopes, Problem Solving, Regional Blood Flow, Task Performance and Analysis, Temporal Lobe, Tomography, Emission-Computed, Visual Perception, Water
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