The DOI matches its Crossref record.
MRI Assessment of Children With Obsessive-Compulsive Disorder or Tics Associated With Streptococcal Infection
Abstract
OBJECTIVE: The authors assessed selective basal ganglia involvement in a subgroup of children with obsessive-compulsive disorder (OCD) and/or tics believed to be associated with streptococcal infection. METHOD: Using computer-assisted morphometric techniques, they analyzed the cerebral magnetic resonance images of 34 children with presumed streptococcus-associated OCD and/or tics and 82 healthy comparison children who were matched for age and sex. RESULTS: The average sizes of the caudate, putamen, and globus pallidus, but not of the thalamus or total cerebrum, were significantly greater in the group of children with streptococcus-associated OCD and/or tics than in the healthy children. The differences were similar to those found previously for subjects with Sydenham's chorea compared with normal subjects. CONCLUSIONS: These results support the hypothesis that there is a distinct subgroup of subjects with OCD and/or tics who have enlarged basal ganglia. These findings are consistent with the hypothesis of an autoimmune response to streptococcal infection.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 5
- Swedo SE, Leonard HL, Garvey M, Mittleman B, Allen AJ, Perlmutter S, Lougee L, Dow S, Zamkoff J, Dubbert BK: Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections: clinical description of the first 50 cases. Am J Psychiatry 1998; 155:264–271 · DOI · Paper page
- Giedd JN, Rapoport JL, Leonard HL, Richter D, Swedo SE: Case study: acute basal ganglia enlargement and obsessive-compulsive symptoms in an adolescent boy. J Am Acad Child Adolesc Psychiatry 1996; 35:913–915 · DOI
- Giedd JN, Snell JW, Lange N, Rajapakse JC, Casey BJ, Kozuch PL, Vaituzis AC, Vauss YC, Hamburger SD, Kaysen D, Rapoport JL: Quantitative magnetic resonance imaging of human brain development: ages 4–18. Cereb Cortex 1996; 6:551–560 · DOI · Paper page
- Snell JW, Merickel MB, Ortega JM, Goble JC, Brookeman JR, Kassell NF: Model-based boundary estimation of complex objects using hierarchical active surface templates. Pattern Recognition 1995; 28:1599–1609 · DOI
- Giedd JN, Rapoport JL, Kruesi MJP, Parker C, Schapiro MB, Allen AJ, Leonard HL, Kaysen D, Dickstein DP, Marsh WL, Kozuch PL, Vaituzis AC, Hamburger S, Swedo SE: Sydenham’s chorea: magnetic resonance imaging of the basal ganglia. Neurology 1995, 45:2199–2202 · DOI
Cited by
Menzies, L., Chamberlain, S. R., Laird, A. R., Thelen, S. M., Sahakian, B. J., & Bullmore, E. T. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.09.005 · Cited by 1,190
Chamberlain, S. R., Blackwell, A. D., Fineberg, N. A., Robbins, T. W., & Sahakian, B. J. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.11.006 · Cited by 830
Boyer, P., & Liénard, P. (2006) · Behavioral and Brain Sciences · doi:10.1017/s0140525x06009332 · Cited by 601
Mapping structural brain alterations in obsessive-compulsive disorder
Pujol, J., Soriano-Mas, C., Alonso, P., Cardoner, N., Menchón, J. M., Deus, J., & Vallejo, J. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.720 · Cited by 429
Leckman, J. F., Denys, D., Simpson, H. B., Mataix-Cols, D., Hollander, E., Saxena, S., Miguel, E. C., Rauch, S. L., Goodman, W. K., Phillips, K. A., et al. (2010) · Depression and Anxiety · doi:10.1002/da.20669 · Cited by 411
Metadata
- Authors
- Giedd, J. N., Rapoport, J. L., Garvey, M. A., Perlmutter, S., & Swedo, S. E.
- Venue
- American Journal of Psychiatry
- Published
- 2000-02-01
- Volume
- 157
- Issue
- 2
- Pages
- 281-283
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2059668493
- Cited by
- 310
- References
- 0
- FWCI
- 28.24
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: MRI Assessment of Children With Obsessive-Compulsive Disorder or Tics Associated With Streptococcal Infection. https://app.cochat.ai/papers/10.1176/appi.ajp.157.2.281
- The paper
- Giedd, J. N., Rapoport, J. L., Garvey, M. A., Perlmutter, S., & Swedo, S. E. (2000). MRI Assessment of Children With Obsessive-Compulsive Disorder or Tics Associated With Streptococcal Infection. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.157.2.281
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
