Decreased Regional Brain Metabolism After ECT
Abstract
OBJECTIVE: The antidepressant action of ECT may be related to its anticonvulsant properties. Positron emission tomography (PET) studies of regional cerebral metabolic rate for glucose were used to test this hypothesis. METHOD: Ten patients with major depression were studied with PET before and approximately 5 days after a course of bilateral ECT. Statistical parametric mapping was used to identify regions of decreased cerebral glucose metabolism. RESULTS: Widespread regions of decreased regional cerebral glucose metabolism were identified after ECT, especially in the frontal and parietal cortex, anterior and posterior cingulate gyrus, and left temporal cortex. A region-of-interest analysis similarly indicated post-ECT reductions in regional cerebral glucose metabolism. CONCLUSIONS: ECT reduces neuronal activity in selected cortical regions, a potential anticonvulsant and antidepressant effect.
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Decreases in sACC activity have been reported following successful treatment of depression with a variety of nonsurgical interventions including pharmacological treatments, electroconvulsive therapy, and transcranial magnetic stimulation.
“Decreases in sACC activity have been reported following successful treatment of depression with a variety of nonsurgical interventions including pharmacological treatments (Mayberg et al. 2000; Drevets et al. 2002), electroconvulsive therapy (Nobler et al. 2001), and transcranial magnetic stimulation (Mottaghy et al. 2002).”
From Anatomical connectivity of the subgenual cingulate region targeted with deep brain stimulation for treatment-resistant depression (2008) · cites this paper as Nobler et al. 2001
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References 74 · Cited by 330
- Authors
- Nobler, M. S., Oquendo, M. A., Kegeles, L. S., Malone, K. M., Campbell, C., Sackeim, H. A., & Mann, J. J.
- Affiliations
- New York State Psychiatric Institute (US)
- Venue
- American Journal of Psychiatry
- Published
- 2001-02-01
- Volume
- 158
- Issue
- 2
- Pages
- 305-308
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2127765363
- Cited by
- 330
- References
- 74
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 8 · 2020: 10 · 2019: 16 · 2018: 17 · 2017: 19 · 2016: 12 · 2015: 17 · 2014: 16 · 2013: 22 · 2012: 20
- FWCI
- 9.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k08mh001244-05)
- National Institute of Mental Health (MH35636, R01MH040695, MH 40695, MH-01244)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- electroconvulsive therapy, regional cerebral glucose metabolism, major depressive disorder, anticonvulsant mechanism, antidepressant mechanism, frontal cortex, parietal cortex, cingulate gyrus, temporal cortex
- MeSH terms
- Brain, Depressive Disorder, Electroconvulsive Therapy, Female, Follow-Up Studies, Frontal Lobe, Glucose, Humans, Functional Laterality, Male, Middle Aged, Tomography, Emission-Computed, Prefrontal Cortex, Fluorodeoxyglucose F18
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