Cerebral phosphate metabolism in first‐degree relatives of patients with schizophrenia
Abstract
OBJECTIVE: Most phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS) studies have described measures of lower membrane anabolism or greater catabolism in the frontal lobes of patients with schizophrenia. The purpose of the present study was to evaluate whether these findings can also be detected in young subjects at genetic risk for schizophrenia. METHOD: Fourteen children and siblings of patients with schizophrenia (mean age=16.7 years) and 14 comparison subjects (mean age=16.9 years) were included in a (31)P-MRS study of the frontal lobe. RESULTS: The high-risk subjects had significantly lower mean ratios of phosphomonoesters to phosphodiesters (0.25 versus 0.31) and higher mean phosphodiester values (37.59% versus 34.87%) than comparison subjects. CONCLUSIONS: These findings suggest greater phospholipid breakdown even in young first-degree relatives of patients with schizophrenia. This suggestion is discussed with respect to the membrane phospholipid hypothesis of schizophrenia.
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Reduced PME and increased PDE levels were observed in the frontal cortex in bipolar disorder and schizophrenia patients, indicating increased lipid breakdown in the brain.
“Reduced PME and increased phosphodiester (PDE) levels were observed in the frontal cortex in BPD and SZ patients, indicating increased lipid breakdown in the brain”
From Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia (2011) · cites this paper as Klemm et al., 2001
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References 14 · Cited by 52
- Authors
- Klemm, S., Rzanny, R., Riehemann, S., Volz, H.-P., Schmidt, B., Gerhard, U.-J., Filz, C., Schönberg, A., Mentzel, H.-J., Kaiser, W. A., & Blanz, B.
- Affiliations
- Friedrich Schiller University Jena (DE)
- Venue
- American Journal of Psychiatry
- Published
- 2001-06-01
- Volume
- 158
- Issue
- 6
- Pages
- 958-960
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2129465602
- Cited by
- 52
- References
- 14
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 2 · 2015: 1 · 2013: 1 · 2012: 2
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Publikationsdatenbank der Fraunhofer-Gesellschaft (Fraunhofer-Gesellschaft) (submittedVersion)
- Fraunhofer-Publica (Fraunhofer-Gesellschaft) (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- schizophrenia, phosphate metabolism, phosphodiester, phosphomonoesters, first-degree relatives, genetic risk, frontal lobe, phosphorus-31 magnetic resonance spectroscopy
- MeSH terms
- Adolescent, Brain, Brain Chemistry, Family, Female, Humans, Male, Magnetic Resonance Spectroscopy, Phosphates, Phosphocreatine, Phospholipids, Phosphorus Isotopes, Schizophrenia, Genetic Predisposition to Disease
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