The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Glutamate and Glutamine Measured With 4.0 T Proton MRS in Never-Treated Patients With Schizophrenia and Healthy Volunteers
Abstract
OBJECTIVE: This in vivo (1)H magnetic resonance spectroscopy study examined levels of glutamate, glutamine, and N-acetylaspartate in patients experiencing their first episode of schizophrenia. METHOD: Localized in vivo (1)H spectra were acquired at 4.0 T from the left anterior cingulate and thalamus of 21 never-treated patients with schizophrenia and 21 comparable healthy volunteers. RESULTS: The level of glutamine was significantly higher in the left anterior cingulate cortex and thalamus of the patients with schizophrenia than in the healthy subjects. No differences were found between groups in the levels of other metabolites in the anterior cingulate or thalamus. CONCLUSIONS: Higher than normal glutamine levels in the left anterior cingulate and thalamus provide in vivo evidence of greater than normal glutamatergic activity proposed by glutamatergic models of schizophrenia. In contrast to other studies in chronically ill patients, no differences were seen in the levels of N-acetylaspartate in either location, suggesting that the findings in patients with chronic schizophrenia may be related to the effect of medication or the progression of the illness.
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Cites
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A glutamatergic deficiency model of schizophrenia
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Bartha, R., Drost, D. J., Menon, R. S., & Williamson, P. (2000) · Magnetic Resonance in Medicine · Cited by 127
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Proton magnetic resonance spectroscopy of the anterior cingulate region in schizophrenia
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Reduced Concentrations of Thalamic N-Acetylaspartate in Male Patients With Schizophrenia
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In vitro 1H-magnetic resonance spectroscopy of postmortem brains with schizophrenia
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Cited by
A pathophysiological framework of hippocampal dysfunction in ageing and disease
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Glutamate and dopamine in schizophrenia: An update for the 21 st century
Howes, O., McCutcheon, R., & Stone, J. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114563634 · Cited by 702
Magnetic Resonance Spectroscopy Studies of Glutamate-Related Abnormalities in Mood Disorders
Yüksel, C., & Öngür, D. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.016 · Cited by 493
Glutamate in Schizophrenia: A Focused Review and Meta-Analysis of 1H-MRS Studies
Marsman, A., van den Heuvel, M. P., Klomp, D. W. J., Kahn, R. S., Luijten, P. R., & Hulshoff Pol, H. E. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr069 · Cited by 457
Hof, P. R., Haroutunian, V., Friedrich, V. L., Byne, W., Buitron, C., Perl, D. P., & Davis, K. L. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00237-3 · Cited by 433
Metadata
- Authors
- Théberge, J., Bartha, R., Drost, D. J., Menon, R. S., Malla, A., Takhar, J., Neufeld, R. W., Rogers, J., Pavlosky, W., Schaefer, B., Densmore, M., Al-Semaan, Y., & Williamson, P. C.
- Venue
- American Journal of Psychiatry
- Published
- 2002-11-01
- Volume
- 159
- Issue
- 11
- Pages
- 1944-1946
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2143126574
- Cited by
- 398
- References
- 10
- FWCI
- 9.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Théberge, J., Bartha, R., Drost, D. J., Menon, R. S., Malla, A., Takhar, J., Neufeld, R. W., Rogers, J., Pavlosky, W., Schaefer, B., Densmore, M., Al-Semaan, Y., & Williamson, P. C. (2002). Glutamate and Glutamine Measured With 4.0 T Proton MRS in Never-Treated Patients With Schizophrenia and Healthy Volunteers. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.159.11.1944
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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