The DOI matches its Crossref record.
Confirmation of Synergy Between Urbanicity and Familial Liability in the Causation of Psychosis
Abstract
OBJECTIVE: This study replicated a previous report that there may be substantial synergism between urbanicity (a proxy environmental risk factor) and familial clustering of psychotic disorder (a proxy genetic risk factor). METHOD: The amount of synergism was estimated from the additive statistical interaction between urbanicity of place of birth and family history of schizophrenia or family history of any severe mental disorder in a population-based Danish cohort of 1,020,063 individuals. RESULTS: There was significant interaction between urbanicity and family history; between 20% and 35% of individuals who had been exposed to both of these risk factors had schizophrenia possibly because of their synergistic effects. CONCLUSIONS: The results suggest that a substantial proportion of the population morbidity force of schizophrenia may be the result of gene-environment interactions associated with urbanicity.
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Citations
Cited by
The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway
Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693
City living and urban upbringing affect neural social stress processing in humans
Lederbogen, F., Kirsch, P., Haddad, L., Streit, F., Tost, H., Schuch, P., Wüst, S., Pruessner, J. C., Rietschel, M., Deuschle, M., et al. (2011) · Nature · doi:10.1038/nature10190 · Cited by 1,584
The environment and schizophrenia
van Os, J., Kenis, G., & Rutten, B. P. F. (2010) · Nature · doi:10.1038/nature09563 · Cited by 1,572
Read, J., van Os, J., Morrison, A. P., & Ross, C. A. (2005) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2005.00634.x · Cited by 1,534
Gene-environment interplay and psychopathology: multiple varieties but real effects
Rutter, M., Moffitt, T. E., & Caspi, A. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01557.x · Cited by 1,058
Metadata
- Authors
- van Os, J., Pedersen, C. B., & Mortensen, P. B.
- Venue
- American Journal of Psychiatry
- Published
- 2004-12-01
- Volume
- 161
- Issue
- 12
- Pages
- 2312-2314
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2156521818
- Cited by
- 181
- References
- 0
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- van Os, J., Pedersen, C. B., & Mortensen, P. B. (2004). Confirmation of Synergy Between Urbanicity and Familial Liability in the Causation of Psychosis. American Journal of Psychiatry. https://doi.org/10.1176/appi.ajp.161.12.2312
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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