Plasticity of cortical activation related to working memory during training
Abstract
OBJECTIVE: Although it is well established that cerebral activation increases with higher task load, the potential effects of training have been investigated over brief periods only. Training is of potential clinical relevance since training programs are an essential part of psychiatric therapy. METHOD: Cerebral activation during a visual spatial working memory task was examined before, during, and after 4 weeks of daily training in nine healthy subjects using functional magnetic resonance imaging. RESULTS: All subjects showed a pronounced activation mainly involving the right inferior frontal gyrus and the right intraparietal sulcus. While the respective regions showed activation increases with improved performance after 2 weeks of training, the activation values decreased at the time of consolidation of performance gains after 4 weeks. CONCLUSIONS: Our results suggest that training-related cerebral activation changes follow an inverse U-shaped quadratic function and raise the prospect of investigating cerebral mechanisms underlying training effects.
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Depending on the task, neuroimaging studies have reported a general decrease in cortical activity, increases in cortical activity, or a more complex redistribution where activity increases in some areas and decreases in others during practice.
“Depending on the task, some studies have reported a general decrease in cortical activity [52–55], a few have reported increases [56–59], and some have reported a more complex redistribution where activity increases in some areas and decreases in others [60–62].”
From Cortical and basal ganglia contributions to habit learning and automaticity (2010) · cites this paper as [53]
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References 14 · Cited by 177
- Authors
- Hempel, A., Giesel, F. L., Garcia Caraballo, N. M., Amann, M., Meyer, H., Wüstenberg, T., Essig, M., & Schröder, J.
- Affiliations
- Heidelberg University (DE)
- Venue
- American Journal of Psychiatry
- Published
- 2004-04-01
- Volume
- 161
- Issue
- 4
- Pages
- 745-747
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2021723366
- Cited by
- 177
- References
- 14
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 13 · 2019: 11 · 2018: 9 · 2017: 6 · 2016: 17 · 2015: 14 · 2014: 14 · 2013: 8 · 2012: 10
- FWCI
- 7.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Functions and Memory
- Keywords
- working memory, cognitive training, neuroplasticity, brain activation, visuospatial working memory, inferior frontal gyrus, intraparietal sulcus, workload, training effects
- MeSH terms
- Adult, Cerebral Cortex, Female, Hemodynamics, Humans, Male, Memory, Neuronal Plasticity, Teaching
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