The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Correlation of Alcohol Craving With Striatal Dopamine Synthesis Capacity and D 2/3 Receptor Availability: A Combined [ 18 F]DOPA and [ 18 F]DMFP PET Study in Detoxified Alcoholic Patients
Abstract
OBJECTIVE: In abstinent alcoholic patients, a low availability of dopamine D2/3 receptors in the ventral striatum and adjacent putamen was associated with a high level of craving for alcohol. Alcohol craving may also depend on presynaptic dysfunction of striatal dopamine production, which may contribute to the risk of relapse. In this study, positron emission tomography (PET) was used to compare dopamine synthesis capacity in the striatum in alcoholic patients and healthy comparison subjects. METHOD: Positron emission tomography (PET) was used to map the net blood-brain clearance of the dopa decarboxylase substrate 6-[18F]fluoro-l-dopa, an index of dopamine synthesis capacity, in the striatum of 12 detoxified male alcoholic patients and 13 age-matched healthy men. The parametric maps were correlated with results of an earlier [18F]desmethoxyfallypride PET study of dopamine D2/3 receptor availability in the same 12 alcoholic patients and in 12 of the healthy volunteers. Alcohol craving was measured with the Alcohol Craving Questionnaire. Patients were followed for 6 months, and alcohol intake was recorded. RESULTS: The magnitude of net blood-brain clearance in the striatum did not differ significantly between detoxified alcoholic patients and the comparison subjects. However, a voxel-wise correlation analysis of net blood-brain clearance in the alcoholic patients linked low levels of dopamine synthesis capacity in the bilateral putamen with high levels of alcohol craving. After normalization of net blood-brain clearance maps to the voxel-wise estimates of dopamine D2/3 receptor availability, there was still a negative correlation with alcohol craving. Alcohol craving at the time of scanning was associated with high level of alcohol intake in the 6-month follow-up period. CONCLUSIONS: Simultaneous assay by PET of pre- and postsynaptic markers of dopamine neurotransmission indicated that a striatal dopamine deficit correlated with alcohol craving, which was associated with a high relapse risk.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In alcohol dependence, Hietala et al (Hietala et al., 1994) showed a decrease in D2 receptor availability in the striatum and this has now been replicated in additional studies (Heinz et al., 2005; Heinz et al., 2004; Martinez et al., 2005; Volkow et al., 1996; Volkow et al., 2002b; Volkow et al., 2007b), although some groups report a lack of a difference”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Heinz et al., 2005
In the citing paper
“In alcohol dependence, imaging studies show a reduction in VMAT2 compared to controls (Gilman et al., 1998) although not of [18F]DOPA uptake (Heinz et al., 2005; Tiihonen et al., 1998).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Heinz et al., 2005
Citations
Cites
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
The neural basis of drug craving: An incentive-sensitization theory of addiction
Robinson, T. (1993) · Brain Research Reviews · doi:10.1016/0165-0173(93)90013-p · Cited by 7,346
Talairach, J., Tournoux, P., & Rayport, M. (1988) · Thieme eBooks · Cited by 5,058
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data
Patlak, C. S., Blasberg, R. G., & Fenstermacher, J. D. (1983) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1983.1 · Cited by 3,565
Drug abuse: hedonic homeostatic dysregulation
Koob, G. F., & Moal, M. L. (1997) · Science · doi:10.1126/science.278.5335.52 · Cited by 2,535
Patlak, C. S., & Blasberg, R. G. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.87 · Cited by 1,673
Haber, S. N., Fudge, J. L., & McFarland, N. R. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02369.2000 · Cited by 1,610
Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex
Volkow, N. D. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.318 · Cited by 1,240
Neurobehavioural mechanisms of reward and motivation
Robbins, T. W., & Everitt, B. J. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80077-8 · Cited by 1,187
Parametric Imaging of Ligand-Receptor Binding in PET Using a Simplified Reference Region Model
Gunn, R. N., Lammertsma, A. A., Hume, S. P., & Cunningham, V. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0303 · Cited by 1,085
Flagged first, then by citations
Cited by
Sorted by citations
Items 101–200 of 284
The Kappa Opioid Receptor Is Associated With Naltrexone-Induced Reduction of Drinking and Craving
de Laat, B., Goldberg, A., Shi, J. M., Tetrault, J. M., Nabulsi, N., Zheng, M., Najafzadeh, S., Gao, H., Kapinos, M., Ropchan, J. R., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.05.021 · Cited by 34
Leri, F., Zhou, Y., Goddard, B., Levy, A., Jacklin, D. L., & Kreek, M. J. (2008) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.09.004 · Cited by 35
Urban, N., & Martínez, D. (2012) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2012.03.011 · Cited by 35
The nucleus accumbens and alcoholism: a target for deep brain stimulation
Ho, A. L., Salib, A.-M. N., Pendharkar, A. V., Sussman, E. S., Giardino, W. J., & Halpern, C. H. (2018) · Neurosurgical FOCUS · doi:10.3171/2018.5.focus18157 · Cited by 34
Disentangling the diverse roles of dopamine D2 receptors in striatal function and behavior
Gallo, E. F. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.01.022 · Cited by 38
Hofmans, L., Papadopetraki, D., van den Bosch, R., Määttä, J. I., Froböse, M. I., Zandbelt, B. B., Westbrook, A., Verkes, R., & Cools, R. (2020) · Neuropsychopharmacology · doi:10.1038/s41386-020-00834-1 · Cited by 37
Addiction and self-determination: A phenomenological approach
Schlimme, J. E. (2010) · Metamedicine · doi:10.1007/s11017-010-9134-0 · Cited by 33
Reid, A. G., Lingford-Hughes, A. R., Cancela, L. M., & Kalivas, P. W. (2012) · Handbook of clinical neurology · doi:10.1016/b978-0-444-52002-9.00024-3 · Cited by 35
Modeling Relapse Situations in the Human Laboratory
Sinha, R. (2011) · Current topics in behavioral neurosciences · doi:10.1007/7854_2011_150 · Cited by 33
Repeated ethanol treatment in adolescent rats alters cortical NMDA receptor
Sircar, R., & Sircar, D. (2006) · Alcohol · doi:10.1016/j.alcohol.2006.07.002 · Cited by 32
Neural Mechanisms Underlying Craving and the Regulation of Craving
Hedy Kober, A., & Mell, M. M. (2015) · Wiley eBooks · doi:10.1002/9781118472415.ch9 · Cited by 33
Jerlhag, E. (2008) · Alcohol · doi:10.1016/j.alcohol.2007.11.004 · Cited by 32
The application of tDCS in psychiatric disorders: a brain imaging view
Baeken, C., Brunelin, J., Duprat, R., & Vanderhasselt, M. (2016) · Socioaffective Neuroscience & Psychology · doi:10.3402/snp.v6.29588 · Cited by 34
Hillmer, A. T., Mason, G. F., Fucito, L. M., O’Malley, S. S., & Cosgrove, K. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12893 · Cited by 32
Hou, H., Wang, C., Jia, S., Hu, S., & Tian, M. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-014-1469-5 · Cited by 33
Imaging resilience and recovery in alcohol dependence
Charlet, K., Rosenthal, A., Lohoff, F. W., Heinz, A., & Beck, A. (2018) · Addiction · doi:10.1111/add.14259 · Cited by 29
Self-citationLawrence, A. D., & Brooks, D. J. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00086 · Cited by 32
Involvement of Dopamine D2 Receptors in Addictive-Like Behaviour for Acetaldehyde
Brancato, A., Plescia, F., Marino, R. A. M., Maniaci, G., Navarra, M., & Cannizzaro, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099454 · Cited by 29
N-methyl-d-aspartic acid receptors are altered by stress and alcohol in Wistar–Kyoto rat brain
Lei, Y., & Tejani‐Butt, S. M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.05.003 · Cited by 29
Insights from recent positron emission tomographic studies of drug abuse and dependence
Chang, L., & Haning, W. (2006) · Current Opinion in Psychiatry · doi:10.1097/01.yco.0000218594.46431.2f · Cited by 27
van den Bosch, R., Hezemans, F. H., Määttä, J. I., Hofmans, L., Papadopetraki, D., Verkes, R., Marquand, A. F., Booij, J., & Cools, R. (2023) · eLife · doi:10.7554/elife.83161 · Cited by 29
Pang, T. Y., Hannan, A. J., & Lawrence, A. J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.02.021 · Cited by 27
Belém-Filho, I. J. A., Ribera, P. C., Nascimento, A. L., Gomes, A. R. Q., Lima, R. R., Lopez, M. E. C., Monteiro, M. C., Fontes-Júnior, E. A., Lima, M. D. O., & Maia, C. D. S. F. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.04.021 · Cited by 25
Luo, S. X., Martínez, D., Carpenter, K. M., Slifstein, M., & Nunes, E. V. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.04.030 · Cited by 22
Söderpalm, B., Danielsson, K., de Bejczy, A., Adermark, L., & Ericson, M. (2019) · Addiction Biology · doi:10.1111/adb.12807 · Cited by 23
Boundary conditions of methamphetamine craving.
Lopez, R. B., Onyemekwu, C. A., Hart, C. L., Ochsner, K. N., & Hedy Kober, A. (2015) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000049 · Cited by 22
Gleich, T., Spitta, G., Butler, O., Zacharias, K., Aydın, S., Sebold, M., Garbusow, M., Rapp, M. A., Schubert, F., Buchert, R., et al. (2020) · Addiction Biology · doi:10.1111/adb.12915 · Cited by 22
Self-citationMolecular imaging in alcohol dependence
Ravan, S., Martínez, D., Slifstein, M., & Abi‐Dargham, A. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00018-5 · Cited by 22
Human dopamine receptor D2/D3 availability predicts amygdala reactivity to unpleasant stimuli
Kobiella, A., Vollstädt‐Klein, S., Fauth‐Bühler, M., Graf, C., Buchholz, H., Bernow, N., Yakushev, I. Y., Landvogt, C., Schreckenberger, M., Gründer, G., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20900 · Cited by 21
Self-citationPopulation-Based Case-Control Study of DRD2 Gene Polymorphisms and Alcoholism
Bhaskar, L. V., Kumarasamy Thangaraj, K., Non, A. L., Singh, L., & Rao, V. R. (2010) · Journal of Addictive Diseases · doi:10.1080/10550887.2010.509274 · Cited by 21
Kienast, T., Siessmeier, T., Wrase, J., Braus, D. F., Smolka, M. N., Buchholz, H. G., Rapp, M. A., Schreckenberger, M., Rösch, F., Cumming, P. D., et al. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-007-0683-z · Cited by 28
Self-citationAlcohol Craving and Relapse Prediction
Heinz, A., Beck, A., Mir, J., Grüsser, S. M., Grace, A. A., & Wrase, J. (2010) · Frontiers in neuroscience · doi:10.1201/9781420007350-c4 · Cited by 20
Self-citationDai, K. Z., Choi, I. B., Levitt, R., Blegen, M. B., Kaplan, A. R., Matsui, A., Shin, J. H., Bocarsly, M. E., Simpson, E. H., Kellendonk, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111440 · Cited by 23
Adolescent intermittent ethanol exposure diminishes anhedonia during ethanol withdrawal in adulthood
Boutros, N., Semenova, S., & Markou, A. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.01.022 · Cited by 19
Ventral Striatal Dopamine Synthesis Capacity Predicts Financial Extravagance in Parkinson’s Disease
Lawrence, A. D., Brooks, D. J., & Whone, A. L. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00090 · Cited by 22
Positron Emission Tomography Molecular Imaging of Dopaminergic System in Drug Addiction
Hou, H., Tian, M., & Zhang, H. (2012) · The Anatomical Record · doi:10.1002/ar.22457 · Cited by 20
Reizinduziertes Alkoholverlangen
Wrase, J., Grüsser, S. M., & Heinz, A. (2006) · Der Nervenarzt · doi:10.1007/s00115-006-2067-1 · Cited by 18
Self-citationPharmacologic treatment of alcoholism
Anton, R. F., Schacht, J. P., & Book, S. W. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-62619-6.00030-6 · Cited by 21
Thiruchselvam, T., Malik, S., & Foll, B. L. (2016) · The American Journal of Drug and Alcohol Abuse · doi:10.1080/00952990.2016.1257633 · Cited by 19
Bağcı, B., Düsmez, S., Zorlu, N., Bahtiyar, G., Işıklı, S., Bayrakçı, A., Heinz, A., Schad, D. J., & Sebold, M. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.960238 · Cited by 17
Self-citationWernicke, C., Hellmann, J., Finckh, U., & Rommelspacher, H. (2010) · Pharmacological Reports · doi:10.1016/s1734-1140(10)70322-4 · Cited by 17
Puls, I., Mohr, J., Wrase, J., Priller, J., Behr, J., Kitzrow, W., Makris, N., Breiter, H. C., Obermayer, K., & Heinz, A. (2008) · Biological Psychology · doi:10.1016/j.biopsycho.2008.03.001 · Cited by 17
Self-citationAlcohol and the dopamine system
Söderpalm, B., & Ericson, M. (2024) · International review of neurobiology · doi:10.1016/bs.irn.2024.02.003 · Cited by 16
Wilcox, C. E., Claus, E. D., Blaine, S. K., Morgan, M., & Hutchison, K. E. (2013) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2013.74.233 · Cited by 17
Weil, Z. M., Karelina, K., & Corrigan, J. D. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.03.012 · Cited by 16
Activators of G-protein signaling 3: a drug addiction molecular gateway
Bowers, M. S. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833dcfa5 · Cited by 15
Kahl, K. G., & Hillemacher, T. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.05.001 · Cited by 15
Lu, L., Yang, W., Zhang, X., Tang, F., Du, Y., Li, F., Luo, J., Yan, C., Zhang, J., Li, J., et al. (2022) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2022.06.036 · Cited by 15
Hasbi, A., Madras, B., & George, S. (2022) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2022.07.003 · Cited by 13
Huys, Q. J. M., Deserno, L., Obermayer, K., Schlagenhauf, F., & Heinz, A. (2016) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2016.06.005 · Cited by 18
Self-citationGuerrin, C. G. J., Tesselaar, D. R. M., Booij, J., Schellekens, A., & Homberg, J. R. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106311 · Cited by 15
Effect of the TaqIA polymorphism on ethanol response in the brain
London, E. D., Berman, S. M., Mohammadian, P., Ritchie, T., Mandelkern, M. A., Susselman, M. K. W., Schlagenhauf, F., & Noble, E. P. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.07.008 · Cited by 14
Increased Turnover of Dopamine in Caudate Nucleus of Detoxified Alcoholic Patients
Kumakura, Y., GJEDDE, A. H., Caprioli, D., Kienast, T., Beck, A., Plotkin, M., Schlagenhauf, F., Vernaleken, I., Gründer, G., Bartenstein, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073903 · Cited by 14
Self-citationHaberstick, B. C., Timberlake, D. S., Smolen, A., Sakai, J. T., Hopfer, C. J., Corley, R. P., Young, S. E., Stallings, M. C., Huizinga, D. H., Menard, S., et al. (2007) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2007.68.362 · Cited by 14
Spitta, G., Fliedner, L., Gleich, T., Zindler, T., Sebold, M., Buchert, R., Heinz, A., Gallinat, J., & Friedel, E. (2022) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2106171 · Cited by 14
Self-citationRecent Progress of Imaging Agents for Parkinson’s Disease
Wu, X., Cai, H., Ge, R., Li, L., & Jia, Z. (2014) · Current Neuropharmacology · doi:10.2174/1570159x13666141204221238 · Cited by 14
Cutuli, D., & Sampedro-Piquero, P. (2022) · Current Neuropharmacology · doi:10.2174/1570159x20666220624111855 · Cited by 16
Imperio, C. G., LEVIN, F. R., & Martínez, D. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20231023 · Cited by 15
Ruiz, P., Calliari, A. J., Genovese, P., Scorza, C., & Pautassi, R. M. (2018) · Brain and Behavior · doi:10.1002/brb3.939 · Cited by 13
A Translational Approach to Novel Medication Development for Protracted Abstinence
Mason, B. J., & Higley, A. E. (2012) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-28720-6_201 · Cited by 12
Yamamoto, Y., Takahata, K., Kubota, M., Takano, H., Takeuchi, H., Kimura, Y., Sano, Y., Kurose, S., Ito, H., Mimura, M., et al. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117543 · Cited by 13
Association of Neuromelanin-Sensitive MRI Signal With Lifetime Substance Use in Young Women
Perlman, G., Wengler, K., Moeller, S. J., Kotov, R., Klein, D. N., Weinstein, J. J., Horga, G., & Abi‐Dargham, A. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20220819 · Cited by 12
Deep Brain Stimulation as a Therapy for Alcohol Addiction
Münte, T. F., Heinze, H., & Visser-Vandewalle, V. E. R. M. (2012) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-28720-6_207 · Cited by 12
Chen, G., & Buck, K. J. (2010) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2010.00611.x · Cited by 12
Sánchez‐Jiménez, F., Pino‐Ángeles, A., Rodríguez-López, R., Morales, M., & Urdiales, J. L. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.08.032 · Cited by 12
Wai, J. M., Grassetti, A., Slifstein, M., Matuskey, D., Nabulsi, N., Ropchan, J. R., Labaree, D. C., Huang, Y. H., & Martínez, D. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107627 · Cited by 12
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515.013 · Cited by 12
PET imaging of dopaminergic system and clinical applications
Sarikaya, İ. (2024) · Clinical and Translational Imaging · doi:10.1007/s40336-024-00646-z · Cited by 11
Chukwueke, C. C., Nona, C. N., McPhee, M. D., Mansouri, E., Rubin-Kahana, D. S., Martinez, D., Boileau, I., Hendershot, C. S., & Foll, B. L. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01095-2 · Cited by 11
Neurobiologie stoffgebundener Abhängigkeitserkrankungen - Befunde bildgebender Verfahren
Kienast, T., Wrase, J., & Heinz, A. (2008) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-2008-1038141 · Cited by 11
Self-citationNeurobiology of Alcohol Craving and Relapse Prediction
Wiers, C. E., & Heinz, A. (2015) · Wiley eBooks · doi:10.1002/9781118472415.ch10 · Cited by 11
Self-citationAdvances in the scientific study of craving for alcohol and tobacco
MacKillop, J., & Monti, P. M. (2007) · Elsevier eBooks · doi:10.1016/b978-008044927-2/50059-6 · Cited by 10
Cumming, P. D., Caprioli, D., & Dalley, J. W. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.01036.x · Cited by 9
Self-citationSerotonin transporter promoter polymorphism and dopaminergic sensitivity in alcoholics
Budde, H., Sander, T., Wernicke, C., Müller, A., Gallinat, J., Schmidt, L., & Smolka, M. N. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0331-9 · Cited by 9
Self-citationHeinz, A., Kipke, R., Müller, S., & Wiesing, U. (2013) · Journal of Medical Ethics · doi:10.1136/medethics-2013-101317 · Cited by 9
Self-citationMathar, D., Wiehler, A., Chakroun, K., Goltz, D., & Peters, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-31531-1 · Cited by 11
Zorick, T. S., Okita, K., Mandelkern, M. A., London, E. D., & Brody, A. L. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz010 · Cited by 10
Brain, behavioral, affective, and sex correlates of recovery from alcohol use disorders
Thompson, B. L., Maleki, N., Kelly, J. F., Sy, K. T. L., & Oscar‐Berman, M. (2021) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14658 · Cited by 9
Say, F. M., Tryhus, A. M., Epperly, P. M., Nader, S. H., Sai, K. K. S., George, B. E., Kirse, H. A., & Czoty, P. W. (2022) · Addiction Biology · doi:10.1111/adb.13219 · Cited by 10
Sebold, M., Spitta, G., Gleich, T., Dembler, T., Butler, O., Zacharias, K., Aydın, S., Garbusow, M., Rapp, M. A., Schubert, F., et al. (2019) · Journal of Neural Transmission · doi:10.1007/s00702-019-01985-2 · Cited by 9
Self-citationThe Dopamine System in Mediating Alcohol Effects in Humans
Beck, A., Ebrahimi, C., Rosenthal, A., Charlet, K., & Heinz, A. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_415 · Cited by 9
Self-citationPadula, C. B., Hansen, A. M., Hughes, R. L., & McNerney, M. W. (2021) · Brain Sciences · doi:10.3390/brainsci11010062 · Cited by 6
Spitta, G., Gleich, T., Rosenthal, A., Schubert, F., Aydın, S., Heinz, A., Buchert, R., & Gallinat, J. (2024) · Addiction Biology · doi:10.1111/adb.13424 · Cited by 7
Self-citationKim, J. S., & Martin‐Fardon, R. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14264 · Cited by 8
Neuronal and psychological underpinnings of pathological gambling
Singer, B. F., Anselme, P., Robinson, M. J. F., & Vezina, P. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00230 · Cited by 8
Changes in Hemodynamic Response Function Resulting From Chronic Alcohol Consumption
Desmond, J. E., Rice, L. C., Cheng, D. T., Hua, J., Qin, Q., Rilee, J. J., Faulkner, M. L., Sheu, Y.-S., Mathena, J. R., Wand, G. S., et al. (2020) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14327 · Cited by 6
Duncan, P. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781139025515 · Cited by 8
Sebold, M., Garbusow, M., Müller, C. A., Charlet, K., & Heinz, A. (2014) · Springer eBooks · doi:10.1007/978-88-470-5322-9_2 · Cited by 6
Self-citationSöderpalm, B., Lidö, H. H., Franck, J., Håkansson, A., Lindqvist, D., Heilig, M. A., Guterstam, J., Samuelson, M., Askerup, B., Nilsson‐Wallmark, C., et al. (2025) · The Lancet Regional Health - Europe · doi:10.1016/j.lanepe.2025.101310 · Cited by 5
Kaminskaitė, M., Jokubka, R., Janavičiūtė, J., Lelytė, I., Šinkariova, L., Pranckevičienė, A., Borutaitė, V., & Bunevičius, A. (2020) · Gene · doi:10.1016/j.gene.2020.145107 · Cited by 5
First, M. B., Carter, C., Castellanos, F. X., Dickstein, D. P., Drevets, W. C., Kim, K. L., Pescosolido, M. F., Rausch, S., Seymour, K. E., & Zubieta, J.-K. (2012) · Cited by 5
Molecular Imaging Studies of Alcohol Use Disorder
Bach, P., de Timary, P., Gründer, G., & Cumming, P. D. (2023) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_414 · Cited by 5
Self-citationProcess addictions in 2012: food, internet and gambling
Zhang, Y., Tian, J., von Deneen, K. M., Liu, Y., & Gold, M. S. (2012) · Neuropsychiatry · doi:10.2217/npy.12.14 · Cited by 5
Neurobiology and computational structure of decision-making in addiction
Huys, Q. J. M., Beck, A., Dayan, P., & Heinz, A. (2014) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-91433 · Cited by 4
Self-citationPrefrontal Limbic-Striatal Circuits and Alcohol Addiction in Humans
Seo, D., & Sinha, R. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405941-2.00003-1 · Cited by 5
Fagundo, A. B., Martín‐Santos, R., Abanades, S., Farré, M., & Verdejo‐García, A. (2008) · Repository of Digital Objects for Teaching Research and Culture (University of Valencia) · Cited by 4
Alkoholmissbrauch und -abhängigkeit im Kindes- und Jugendalter
Pogarell, O. M., Karamatskos, E., & Koller, G. (2009) · Monatsschrift Kinderheilkunde · doi:10.1007/s00112-009-2059-x · Cited by 4
Neurochemical Imaging of Addictive Disorders
Broft, A. I., & Martínez, D. (2012) · Neuromethods · doi:10.1007/7657_2012_48 · Cited by 4
Shea, C. W. (2008) · Southern Medical Journal · doi:10.1097/smj.0b013e3181617307 · Cited by 4
Sebold, M., Hägele, C., Beck, A., & Heinz, A. (2013) · SUCHT - Zeitschrift für Wissenschaft und Praxis / Journal of Addiction Research and Practice · doi:10.1024/0939-5911.a000255 · Cited by 3
Self-citation
Metadata
- Authors
- Heinz, A., Siessmeier, T., Wrase, J., Buchholz, H. G., Gründer, G., Kumakura, Y., Cumming, P., Schreckenberger, M., Smolka, M. N., Rösch, F., Mann, K., & Bartenstein, P.
- Affiliations
- Central Institute of Mental Health (DE)
- ORCID
- Venue
- American Journal of Psychiatry
- Published
- 2005-08-01
- Volume
- 162
- Issue
- 8
- Pages
- 1515-1520
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2121548568
- Cited by
- 285
- References
- 30
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 6 · 2023: 5 · 2022: 9 · 2021: 9 · 2020: 31 · 2019: 14 · 2018: 15 · 2017: 13 · 2016: 15 · 2015: 11 · 2014: 22 · 2013: 13 · 2012: 24
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- alcohol craving, alcoholism, dopamine synthesis capacity, dopamine D2/D3 receptors, striatum, putamen, alcohol relapse, alcohol abstinence, dopamine signaling, alcohol consumption
- MeSH terms
- Adult, Alcoholism, Blood-Brain Barrier, Corpus Striatum, Dopamine, Fluorine Radioisotopes, Follow-Up Studies, Humans, Levodopa, Male, Middle Aged, Recurrence, Risk Factors, Salicylamides, Dopamine Agents, Behavior, Addictive, Receptors, Dopamine D2, Positron-Emission Tomography, Receptors, Dopamine D3
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review