Stimulant medications: how to minimize their reinforcing effects?
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The large and abrupt dopamine increase after intravenous administration is perceived as reinforcing, an effect that appears to be reduced when the increase in dopamine is slow and progressive.
“The large and abrupt dopamine increase after intravenous administration is perceived as reinforcing, an effect that appears to be reduced when the increase in dopamine is slow and progressive (Volkow, 2006).”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Volkow, 2006
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References 6 · Cited by 70
- Authors
- VOLKOW, N. D.
- Corresponding author
- VOLKOW, NORA D.
- ORCID
- VOLKOW, NORA D.
- Venue
- American Journal of Psychiatry
- Published
- 2006-03-01
- Volume
- 163
- Issue
- 3
- Pages
- 359-361
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2016508442
- Cited by
- 70
- References
- 6
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2016: 1 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 8
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- stimulant medication, reinforcement effect, drug reinforcement, stimulant abuse, addiction prevention
- MeSH terms
- Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Brain, Chemistry, Pharmaceutical, Delayed-Action Preparations, Dopamine, Dose-Response Relationship, Drug, Humans, Methylphenidate, Reinforcement, Psychology, Reward, Behavior, Addictive, Substance-Related Disorders, Dopamine Plasma Membrane Transport Proteins
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