Sleep Disturbance in Bipolar Disorder: Therapeutic Implications
Abstract
In this review, the authors detail our current understanding of the crucial role that sleep and its disturbances play in bipolar disorder. Multiple lines of evidence suggest that impaired sleep can induce and predict manic episodes. Similarly, treatment of sleep disturbance may serve as both a target of treatment and a measure of response in mania. The depressive phase of bipolar illness is marked by sleep disturbance that may be amenable to somatic therapies that target sleep and circadian rhythms. Residual insomnia in the euthymic period may represent a vulnerability to affective relapse in susceptible patients. Given the importance of sleep in all phases of bipolar disorder, appropriate evaluation and management of sleep disturbance in patients with bipolar illness is further detailed.
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Prolonged nighttime social media use can significantly impact mood stability.
“Since sleep disturbances are a well-established trigger for both manic and depressive episodes, prolonged nighttime social media use can significantly impact mood stability [57].”
From The Impact of Social Media & Technology on Child and Adolescent Mental Health (2025) · cites this paper as [57]
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References 153 · Cited by 268
- Authors
- Plante, D. T., & Winkelman, J. W.
- Affiliations
- Harvard University (US)
- Venue
- American Journal of Psychiatry
- Published
- 2008-07
- Volume
- 165
- Issue
- 7
- Pages
- 830-843
- ISSN
- 0002-953X (ISSN-L)
- 1535-7228
- OpenAlex
- W2117614899
- Cited by
- 268
- References
- 153
- Citations by year
- 2026: 9 · 2025: 12 · 2024: 6 · 2023: 10 · 2022: 11 · 2021: 11 · 2020: 15 · 2019: 14 · 2018: 7 · 2017: 16 · 2016: 20 · 2015: 30 · 2014: 25 · 2013: 27 · 2012: 14
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep disorders, bipolar disorder, insomnia, manic episodes, circadian rhythm, treatment response monitoring
- MeSH terms
- Bipolar Disorder, Major Depressive Disorder, Homeostasis, Humans, Sleep Initiation and Maintenance Disorders, Sleep Deprivation, Polysomnography, Sleep Disorders, Circadian Rhythm, REM Sleep Behavior Disorder, Diagnostic and Statistical Manual of Mental Disorders
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