Cited by 256Pain Management and Placebo EffectTreatment of Major DepressionStatistical Methods in Clinical Trials

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Placebo Response in Randomized Controlled Trials of Antidepressants for Pediatric Major Depressive Disorder

Bridge, Jeffrey A., Birmaher, Boris, Iyengar, Satish, Barbe, Rémy P., Brent, David A.·2009·American Journal of Psychiatry

DOI 10.1176/appi.ajp.2008.08020247

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Abstract

Objective: The authors examined characteristics and predictors of response to placebo in all available reports of short-term randomized controlled trials of antidepressants for pediatric major depressive disorder. Method: Response, defined as a score ≤2 on the improvement item of the Clinical Global Impression scale, and potential predictors were extracted from 12 published and unpublished randomized controlled trials of second-generation antidepressants in participants 6–18 years of age with major depression. Results: The single best predictor of the proportion of patients taking placebo who responded to treatment was the number of study sites. Baseline severity of illness also emerged as a significant inverse predictor of placebo response, although the strength of this relationship was diminished when number of sites was controlled for. After one large fluoxetine trial was excluded, younger participants showed a higher placebo response rate than older adolescents. Higher placebo response rates in more recent studies were explained by an increasing trend toward large multisite trials and by publication delays and failures to publish some negative trials. Conclusions: The recent shift toward large multisite trials of antidepressant medications for pediatric major depression may be contributing to an increasing incidence of response to placebo. Pharmacotherapy studies of pediatric depression that carefully recruit patients with at least moderately severe depression may be more informative and efficient than many trials conducted to date. Such studies should have sufficient power to determine whether age moderates medication and placebo response.

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Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Classification and Regression Trees.
Gordon, A. D., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1984) · Biometrics · doi:10.2307/2530946 · Cited by 23,867
Classification and Regression Trees.
Ryzin, J. V., Breiman, L., Friedman, J. H., Olshen, R. A., & Stone, C. J. (1986) · Journal of the American Statistical Association · doi:10.2307/2288003 · Cited by 21,030
Initial Severity and Antidepressant Benefits: A Meta-Analysis of Data Submitted to the Food and Drug Administration
Kirsch, I., Deacon, B. J., Huedo-Medina, T. B., Scoboria, A., Moore, T. J., & Johnson, B. T. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050045 · Cited by 2,442
Selective publication of antidepressant trials and its influence on apparent efficacy
Turner, E. H., Matthews, A. M., Linardatos, E., Tell, R. A., & Rosenthal, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmsa065779 · Cited by 2,435
ECDEU Assessment Manual: (591322011-001)
Guy, W. (1976) · PsycEXTRA Dataset · doi:10.1037/e591322011-001 · Cited by 1,896
Fluoxetine, Cognitive-Behavioral Therapy, and Their Combination for Adolescents With Depression: Treatment for Adolescents With Depression Study (TADS) Randomized Controlled Trial
(2004) · JAMA · doi:10.1001/jama.292.7.807 · Cited by 1,735
Neuropsychopharmacology
Bunney, W. E., Hippius, H., Laakmann, G., & Schmauß, M. (1990) · Springer eBooks · doi:10.1007/978-3-642-74034-3 · Cited by 1,523
Placebo Response in Studies of Major Depression: Variable, Substantial, and Growing
Walsh, B. T., Seidman, S. N., Sysko, R., & Gould, M. (2002) · JAMA · doi:10.1001/jama.287.14.1840 · Cited by 1,109

Flagged first, then by citations

Show all 48 references

Research works printed but not linked: 11

Koppelman J, 2004, NHPF Issue Brief, 801, 1
Wilcox CS, 1992, Psychopharmacol Bull, 28, 157
Hammad TA, 2004, Review and evaluation of clinical data
Poznanski E, 1995, Mokros H: Children's Depression Rating Scale-Revised (CDRS-R)
March J, JAMA 2004; 292: 807-820
Emslie GJ, 2002, J Child Adolesc Psychopharmacol, 12, 299
Dubitsky GM, 2004, Review and evaluation of clinical data: placebocontrolled antidepressant studies in pediatric patients
US Food and Drug Administration, 2002, NDA: 20-152. S-032, nefazodone hydrochloride (Serzone).
Emslie GJ, 2002, 42nd Annual Meeting of the National Institute of Mental Health: New Clinical Drug Evaluation Unit (NCDEU). Boca Raton
Birmaher B, 2000, Comorbid ADHD and other disruptive behavior disorders as predictors of response in adolescents treated for major depression, poster, 153rd annual meeting of the American Psychiatric Association
Breiman L, 1984, Olshen RA

Sorted by citations

Items 101–200 of 254

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National time trend changes in psychotropic medication of child and adolescent psychiatric inpatients across Finland
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Smith, E. A., Horan, W. P., Demolle, D., Schueler, P., Fu, D., Anderson, A., Geraci, J., Butlen‐Ducuing, F., Link, J., Khin, N. A., et al. (2022) · PubMed Central · Cited by 12
Placebo for depression: we need to improve the quality of scientific information but also reject too simplistic approaches or ideological nihilism
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Comparing apples and oranges in youth depression treatments? A quantitative critique of the evidence base and guidelines
Stringaris, A. K., Burman, C., Delpech, R., Uher, R., Bhudia, D., Miliou, D., Rokas, I.-M., Kyriakopoulos, M., Foulkes, L., Moreno, C., et al. (2025) · BMJ Mental Health · doi:10.1136/bmjment-2024-301162 · Cited by 12
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Riley, A. R., & Gaynor, S. T. (2014) · Behavior Modification · doi:10.1177/0145445514530756 · Cited by 12
Nouveaux enjeux de la recherche clinique en psychopharmacologie chez l’enfant et l’adolescent
Auby, P. (2011) · Neuropsychiatrie de l Enfance et de l Adolescence · doi:10.1016/j.neurenf.2011.04.007 · Cited by 11
Pharmacotherapy and psychotherapy of pediatric depression
Maalouf, F. T., & Brent, D. A. (2010) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2010.496451 · Cited by 10
Self-citation
Initial Dose of Antidepressant and Suicidal Behavior in Youth
Brent, D. A., & Gibbons, R. D. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.14016 · Cited by 12
Self-citation
Use of band-pass filter analysis to evaluate outcomes in an antidepressant trial for treatment resistant patients
Targum, S. D., BURCH, D. J., Asgharnejad, M., Petersen, T., Goméni, R., & D, M. F. M. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.06.003 · Cited by 10
Escitalopram for the treatment of major depressive disorder in youth
Ahn, J., & Patkar, A. A. (2011) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2011.604632 · Cited by 10
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Wang, X., Zhang, Z., Li, Y., Gao, Y., & Cao, Q.-J. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.120132 · Cited by 8
Is Placebo Response Responsible for Many Phase III Failures?
Dumitrescu, T. P., McCune, J., & Schmith, V. D. (2019) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.1632 · Cited by 8
Youth Depression and Suicide: Selective Serotonin Reuptake Inhibitors Treat the Former and Prevent the Latter
Brent, D. A. (2009) · The Canadian Journal of Psychiatry · doi:10.1177/070674370905400204 · Cited by 8
Self-citation
Selective Serotonin Reuptake Inhibitors (SSRIs)
Sakolsky, D. J., & Birmaher, B. B. (2012) · Wiley eBooks · doi:10.1002/9781119958338.ch8 · Cited by 9
Self-citation
Treatment of Depressed Adolescents
Walkup, J. T. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10040566 · Cited by 8
Inappropriate Data and Measures Lead to Questionable Conclusions
Spielmans, G. I., Jureidini, J. N., Healy, D., & Purssey, R. (2013) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2013.747 · Cited by 8
Do we need more than one antidepressant for patients with major depressive disorder?
Pae, C., Han, C., & Jun, T. (2011) · Expert Review of Neurotherapeutics · doi:10.1586/ern.11.150 · Cited by 7
Meta-Analysis: Pediatric Placebo Response in Depression Trials Does Not Replicate in Anxiety and Obsessive-Compulsive Disorder Trials
Nasir, M., Li, F., Courley, S., Olten, B., & Bloch, M. H. (2021) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2021.0030 · Cited by 7
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Findling, R. L., Groark, J., Tourian, K. A., Ramaker, S., Chiles, D., Yang, L., & Nichols, A. I. (2016) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2016.0009 · Cited by 6
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Antidepressants in paediatric depression: do not look back in anger but around in awareness
Brent, D. A., Gibbons, R. D., Wilkinson, P. O., & Dubicka, B. (2018) · BJPsych Bulletin · doi:10.1192/bjb.2017.2 · Cited by 6
Self-citation
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Safety and Efficacy of Adjunctive Second-Generation Antidepressant Therapy With A Mood Stabiliser or an Atypical Antipsychotic in Acute Bipolar Depression: Randomised Systematic Review and Meta-Analysis of A Placebo-Controlled Trials
McGirr, A., Vöhringer, P. A., Ghaemi, S. N., Lam, R. W. M., & Yatham, L. N. (2021) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.19102 · Cited by 6
The Search for Improved Antidepressant Strategies: Is Bigger Better?
Coryell, W. H. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11030510 · Cited by 6
Behavioral Therapy, Sertraline, or Both in Childhood Anxiety
Rifkin, A. E., & Braga, R. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmc090139 · Cited by 6
Is the Efficacy of “Antidepressant” Medications Overrated?
Deacon, B. J., & Spielmans, G. I. (2017) · Wiley eBooks · doi:10.1002/9781119095910.ch13 · Cited by 7
The European Union Pediatric legislation: impact on pharmaceutical research in pediatric populations
Auby, P. (2014) · Clinical Investigation · doi:10.4155/cli.14.101 · Cited by 5
Comparison of novel methods in two‐way enriched clinical trial design
Liu, Y., Rybin, D. V., Heeren, T., & Doros, G. D. (2019) · Statistics in Medicine · doi:10.1002/sim.8288 · Cited by 5
Greater Dynamic and Lower Static Functional Brain Connectivity Prospectively Predict Placebo Response in Pediatric Generalized Anxiety Disorder
Lu, L., Li, H., Mills, J. A., Schroeder, H. K., Mossman, S. A., Varney, S. T., Cecil, K. M., Huang, X., Gong, Q., Levine, A. A., et al. (2020) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2020.0024 · Cited by 5
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Authors: Bridge, J. A., Birmaher, B., Iyengar, S., Barbe, R. P., & Brent, D. A.
Affiliations: Nationwide Children's Hospital (US)
ORCID: Bridge, Jeffrey A.
Birmaher, Boris
Iyengar, Satish
Barbe, Rémy P.
Brent, David A.
Venue: American Journal of Psychiatry
Publisher: American Psychiatric Association Publishing
Published: 2009-01
Volume: 166
Issue: 1
Pages: 42-49
ISSN: 0002-953X (ISSN-L)
1535-7228
DOI: 10.1176/appi.ajp.2008.08020247
OpenAlex: W2137044513
Cited by: 256
References: 48
Citations by year: 2026: 6 · 2025: 9 · 2024: 11 · 2023: 2 · 2022: 12 · 2021: 12 · 2020: 9 · 2019: 14 · 2018: 19 · 2017: 16 · 2016: 14 · 2015: 27 · 2014: 22 · 2013: 14 · 2012: 12
FWCI: 1.40
Type: journal article
Language: en
Open access: closed
Locations: American Journal of Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (K01 MH-69948, K01MH069948, P30MH066371, P30 MH-66371)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
Keywords: placebo response, antidepressants, second-generation antidepressants, age differences, publication bias, Clinical Global Impression Scale, multisite trials, fluoxetine
MeSH terms: Adolescent, Age Factors, Child, Major Depressive Disorder, Humans, Personality Assessment, Multicenter Studies as Topic, Placebo Effect, Randomized Controlled Trials as Topic, Treatment Outcome, Publication Bias

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Placebo Response in Randomized Controlled Trials of Antidepressants for Pediatric Major Depressive Disorder

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